An expeditious route to fluorinated rapamycin analogues by utilising mutasynthesis

ChemBioChem

Volumn 11, Issue 5, 2010, Pages 698-702

  Goss, Rebecca J M ^a   Lanceron, Simon ^a   Roy, Abhijeet Deb ^a   Sprague, Simon ^b   Nur e Alam, Mohammed ^b   Hughes, David L ^a   Wilkinson, Barrie ^b   Moss, Steven J ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b BIOTICA TECHNOLOGY LTD   (United Kingdom)

Author keywords

Antitumor agents; Biosynthesis; Fluorine; Immunosuppressants; Natural products

Indexed keywords

39 DESMETHOXY 39 FLUORO 9 DEOXO 16 O DESMETHYL 27 DESMETHOXYRAPAMYCIN; RAPAMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; DRUG SYNTHESIS; HYDROXYLATION; PRIORITY JOURNAL; RING OPENING; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ANTIBIOTICS, ANTINEOPLASTIC; CRYSTALLOGRAPHY, X-RAY; FLUORINE; MOLECULAR CONFORMATION; SIROLIMUS; STEREOISOMERISM;

EID: 77949871655     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900723     Document Type: Article

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