Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2306-2310

  Sondhi, Sham M ^a   Rani, Reshma ^a   Singh, Jaiveer ^a   Roy, Partha ^a   Agrawal, S K ^b   Saxena, A K ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Anti inflammatory; Anticancer; Benzimidazole; Heterocyclic; Microwave

Indexed keywords

2,3 PYRAZINEDICARBOXLIC ACID; BENZIMIDAZOLE DERIVATIVE; HOMOPHTHALIC ACID; IBUPROFEN; SOLVENT; SUCCINIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST; CANCER CELL CULTURE; CELL STRAIN MCF 7; CENTRAL NERVOUS SYSTEM; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LUNG; MALE; MICROWAVE IRRADIATION; NONHUMAN; OVARY; POLYMERIZATION; PROSTATE; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; MICROWAVES; NEOPLASMS; OVARIAN NEOPLASMS;

EID: 77949772550     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.147     Document Type: Article

References (28)

1. Sawyer T.K. In: Bradbury R.H. (Ed). Topics in Medicinal Chemistry Vol. 1 (2007), Springer, Berlin 383 Chapter 8
2. Parshanath A., and David W.W. J. Am. Chem. Soc. 131 (2009) 7618
3. Jao C.W., Lin W.C., Wu Y.T., and Wu P.L. J. Nat. Prod. 71 (2008) 1275
4. Guillaumel J., Leonce S., Pierre A., Renard P., Pfeiffer B., Arimondo P.B., and Monneret C. Eur. J. Med. Chem. 41 (2006) 379
5. Heinemann C., Schliemann-Willers S., Oberthur C., Hamburger M., and Elsner P. Planta Med. 70 (2004) 385
6. Selcen A., Seil Z., Istvan Z., Gunes C., Borbala R., Smith G.H., and Zeki T. J. Enzyme Inhib. Med. Chem. 24 (2009) 849
7. Bluhm, H.; Gege, C.; Hochguertel, M.; Taveras, A. PCT Int. Appl. WO 2008109179, 2008 Chem Abstr. 149, 355744.
8. Dalton, J. T.; Miller, D. D.; Mohler, M. L.; Wu, Z.; Hong, S.-S. PCT Int. Appl. WO 2008091555, 2008, Chem. Abstr. 149, 200795.
9. Valderrama J.A., Ibacache J.A., Arancibia V., Rodriguez J., and Theoduloz C. Bioorg. Med. Chem. 17 (2009) 2894
10. Tsou H.-R., Liu X., Birnberg G., Kaplan J., Otteng M., Tran T., Kutterer K., Tang Z., Suayan R., Zask A., Ravi M., Bretz A., Grillo M., McGinnis J.P., Rabindran S.K., Ayral-Kaloustian S., and Mansour T.S. J. Med. Chem. 52 (2009) 2289
11. Monteiro P., Gilot D., Langouet S., and Fardel O. Drug Metab. Disposit. 36 (2008) 2556
12. Turabekova M.A., Vinogradova V.I., Rasulev B.F., Levkovich M.G., Werbovetz K., Capers J., and Abdullaev N.D. Chem. Nat. Compd. 44 (2008) 341
13. Slaninova I., Slunska Z., Sinkora J., Vlkova M., and Taborska E. Pharm. Biol. 45 (2007) 131
14. Capasso A. Rec. Res. Dev. Biochem. 6 (2005) 1
15. Shevyakov S.V., Davydova O.I., Pershin D.G., Krasavin M., Kravchenko D.V., Kiselyov A., Tkachenko S.E., and Ivachtchenko A.V. Nat. Prod. Res., Part A 20 (2006) 735
16. Jao C.-W., Lin W.-C., Wu Y.-T., and Wu P.-L. J. Nat. Prod. 7 (2008) 1257
17. Natacha M., Pascal C., Benoit R., Jean-Francois G., Raymond H., Christian B., and Jean-Pierre H. Bioorg. Med. Chem. 12 (2004) 641
18. Sondhi S.M., Dinodia M., Jain S., and Kumar A. Eur. J. Med. Chem. 43 (2008) 2824
19. Sondhi S.M., Singh J., Kumar A., Jamal H., and Gupta P.P. Eur. J. Med. Chem. 44 (2009) 1010
20. Sondhi S.M., Rani R., Gupta S.K., Agrawal P.P., and Saxena A.K. Mol. Div. 5 (2009) 51
21. Sahu R.K., Magan A., Gupta B., and Sondhi S.M. Phosphorus Sulfur, Silicon 88 (1994) 45
22. Sondhi S.M., and Rani R. Lett. Org. Chem. 5 (2008) 51
23. Sondhi S.M., Rani R., Partha R., Agrawal S.K., and Saxena A.K. Bioorg. Med. Chem. Lett. 19 (2009) 1534
24. Sondhi, S. M.; Rani, R. Green Chem. Lett. Rev., 2010, doi:10.1080/17518250903583706.
25. 2), 3.46 (s, 1H, -CH{double bond, long}), 7.51-7.52 (m, 1H, Ar), 7.71-7.19 (m, 1H, Ar)
26. Winter C.A., Risley E.A., and Nuss G.W. Proc. Soc. Exp. Biol. Med. 111 (1962) 544
27. Monks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., Hose C., Langley J., and Cronise P. J. Natl. Cancer Inst. 83 (1991) 757
28. Skehan P., Storeng R., Scudiero D., Monks A., McMohan J., Vistica D., Warren J.T., Bokesch H., Kenney S., and Boyd M.R. J. Natl. Cancer Inst. 82 (1990) 1107