Transgenic mice expressing nitroreductase gene under the control of the podocin promoter: A new murine model of inductible glomerular injury

Virchows Archiv

Volumn 456, Issue 3, 2010, Pages 325-337

  MacAry, Guillaume ^a   Rossert, Jérome ^d   Bruneval, Patrick ^a,b,c   Mandet, Chantal ^a   Bélair, Marie France ^a   Houillier, Pascal ^a,b,c   Van Huyen, Jean Paul Duong ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d AMGEN INC   (United States)

Author keywords

Focal segmental glomerulosclerosis; Kidney disease progression; Nitroreductase; Podocytes; Proteinuria; Transgenic models

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ALPHA SMOOTH MUSCLE ACTIN; CELL PROTEIN; CREATININE; DESMIN; KI 67 ANTIGEN; NEPHRIN; NITROREDUCTASE; PODOCIN; SYNAPTOPODIN; TRANSCRIPTION FACTOR; 5-(1-AZIRIDINYL)-2,4-DINITROBENZAMIDE; AZIRIDINE DERIVATIVE; MEMBRANE PROTEIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BOWMAN CAPSULE; CELL DEDIFFERENTIATION; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; FEMALE; FOCAL GLOMERULOSCLEROSIS; GENE CONTROL; GENE EXPRESSION; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; HISTOPATHOLOGY; HYALINE DEGENERATION; KIDNEY BIOPSY; KIDNEY FIBROSIS; MOUSE; NONHUMAN; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEINURIA; SUICIDE TRANSGENE; TRANSGENIC MOUSE; ANIMAL; CHEMICALLY INDUCED DISORDER; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; AZIRIDINES; DISEASE MODELS, ANIMAL; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NITROREDUCTASES; PODOCYTES; PROMOTER REGIONS, GENETIC;

EID: 77949763113     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-009-0840-9     Document Type: Article

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