Inducible ablation of adipocytes in adult transgenic mice expressing the E. coli nitroreductase gene

Journal of Endocrinology

Volumn 175, Issue 2, 2002, Pages 487-498

  Felmer, R ^a   Cui, W ^a   Clark, A J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; GLUCOSE; LEPTIN; NITROREDUCTASE; PRODRUG; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOSE TISSUE; AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BACTERIAL GENE; BODY TEMPERATURE; CELL COUNT; CELL DEATH; CELL POPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVELOPMENTAL STAGE; DOSE RESPONSE; ESCHERICHIA COLI; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; LOW DRUG DOSE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TARGET CELL; THERMOREGULATION; TIME; TISSUE REGENERATION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; APOPTOSIS; AZIRIDINES; BLOOD GLUCOSE; BLOTTING, NORTHERN; BLOTTING, WESTERN; BODY WEIGHT; GENES; LEPTIN; MALE; MICE; MICE, TRANSGENIC; NITROREDUCTASES; PRODRUGS; PROMOTER REGIONS (GENETICS); TRIGLYCERIDES;

EID: 0036854385     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1750487     Document Type: Review

References (24)

1. Ailaud G & Hauner H 1998 Development of white adipose tissue. In Handbook of Obesity, pp 359-378, Eds GA Bray, C Bouchard & WPT James. New York: Marcel Dekker.
2. Borrelli E, Heyman RA, Arias C, Sawchenko PE & Evans RM 1989 Transgenic mice with inducible dwarfism. Nature 15 538-541.
3. Breitman ML, Clapoff S, Rossant J, Tsui LC, Glode LM, Maxwell IH & Bernstein A 1987 Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science 238 1563-1565.
4. Burant CF, Sreenan S, Hirano K, Tai TA, Lohmiller J, Lukens J, Davidson NO, Ross S & Graves RA 1997 Troglitazone action is independent of adipose tissue. Journal of Clinical Investigation 11 2900-2908.
5. Clark AJ, Iwobi M, Cui W, Crompton M, Harold G, Hobbs S, Kamalati T, Knox R, Neil C, Yull F & Gusterson B 1997 Selective cell ablation in transgenic mice expression E coli nitroreductase. Gene Therapy 2 101-110.
6. Cui W, Gusterson B & Clark AJ 1999 Nitroreductase mediated cell ablation is very rapid and mediated by a p-53 independent apoptotic pathway. Gene Therapy 6 764-770.
7. Cui W, Allen ND, Skynner M, Gusterson B & Clark AJ 2001 Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain. Glia 34 272-282.
8. Dobie KW, Lee M, Fantes JA, Graham E, Clark AJ, Springbett A, Lathe R & McClenaghan M 1996 Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus. PNAS 13 6659-6664.
9. Drabek D, Guy J, Craig R & Grosveld F 1997 The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954. Gene Therapy 4 93-100.
10. Faust IM, Johnson PR & Hirsch J 1977 Adipose tissue regeneration following lipectomy. Science 197 391-393.
11. Festenstein R, Tolaini M, Corbella P, Mamalaki C, Parrington J, Fox M, Miliou A, Jones M & Kioussis D 1996 Locus control region function and heterochromatin-induced position effect variegation. Science 271 1123-1125.
12. Flier JS 1997 Leptin expression and action: new experimental paradigms. PNAS 9 4242-4245.
13. Himms-Hagen J 1990 Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB Journal 11 2890-2898.
14. Houstek J, Kopecky J, Rychter Z & Soukup T 1988 Uncoupling protein in embryonic brown adipose tissue - existence of nonthermogenic and thermogenic mitochondria. Biochimica et Biophysica Acta 1 19-25.
15. Isles AR, Ma D, Milsom C, Skynner MJ, Cui W, Clark AJ, Keverne EB & Allen ND 2001 Conditional ablation of neurones in transgenic mice. Journal of Neurobiology 3 183-193.
16. Knox RJ, Friedlos F & Boland MP 1993 The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). Cancer and Metastasis Reviews 2 195-212.
17. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP & Flier JS 1993 Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 6457 740-742.
18. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML & Vinson C 1998 Life without white fat: a transgenic mouse. Genes and Development 20 3168-3181.
19. Robertson G, Garrick D, Wilson M, Martin DI & Whitelaw E 1996 Age-dependent silencing of globin transgenes in the mouse. Nucleic Acids Research 8 1465-1471.
20. Rogers P & Webb GP 1980 Estimation of body fat in normal and obese mice. British Journal of Nutrition 43 83-86.
21. Ross SR, Graves RA, Greenstein A, Platt KA, Shyu HL, Mellovitz B & Spiegelman BM 1990 A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo. PNAS 87 9590-9594.
22. Ross SR, Graves RA & Spiegelman BM 1993 Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes and Development 7 1318-1324.
23. Roth J, Greenwood MR & Johnson PR 1981 The regenerating fascial sheath in lipectomized Osborne-Mendel rats: morphological and biochemical indices of adipocyte differentiation and proliferation. International Journal of Obesity 2 131-143.
24. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL & Brown MS 1998 Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes and Development 20 3182-3194.