Novel nucleophilic compounds with oxime group as reactivators of paraoxon-inhibited cholinesterases

Letters in Drug Design and Discovery

Volumn 7, Issue 4, 2010, Pages 260-264

  Musilova, Lucie ^a   Jun, Daniel ^b,c   Palecek, Jiri ^d   Cirkva, Vladimir ^e   Musilek, Kamil ^b   Paar, Martin ^a   Hrabinova, Martina ^b   Pohanka, Miroslav ^b   Kuca, Kamil ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

^d LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^e INSTITUTE OF CHEMICAL PROCESS FUNDAMENTALS   (Czech Republic)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Nerve agent; Oxime; Paraoxon; Pesticide; Reactivator; Scavenger

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (ISOQUINOLINIUM) 4 (2 HYDROXYIMINOMETHYLPYRIDINIUM) BUT 2 ENE DIBROMIDE; 1 (PYRIDINIUM) 4 (2 HYDROXYIMINOMETHYLPYRIDINIUM) BUT 2 ENE DIBROMIDE; 1 (QUINOLINIUM) 4 (2 HYDROXYIMINOMETHYLPYRIDINIUM) BUT 2 ENE DIBROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; K 064; K 065; K 066; NUCLEOPHILE; OBIDOXIME; OXIME DERIVATIVE; PARAOXON; PRALIDOXIME; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; INTOXICATION; PRIORITY JOURNAL; PROPHYLAXIS; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 77949761812     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018010790945823     Document Type: Article

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