Preparation of resveratrol-loaded poly(ε-caprolactone) nanoparticles by oil-in-water emulsion solvent evaporation method

Food Science and Biotechnology

Volumn 18, Issue 1, 2009, Pages 157-161

  Kim, Bum Keun ^a   Lee, Jun Soo ^a   Oh, Ju Kyoung ^a   Park, Dong June ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Emulsion solvent evaporation; Encapsulation efficiency; Nanoparticle; Poly( caprolactone); Resveratrol

Indexed keywords

ATOMIC FORCE MICROSCOPES; CAPROLACTONE; DISPERSED PHASE; EMULSION SOLVENT EVAPORATION; ENCAPSULATION EFFICIENCY; MEAN PARTICLE SIZE; MEAN SIZE; OIL-IN-WATER (O/W) EMULSION; OIL-IN-WATER EMULSIONS; PLURONIC F-127; RESVERATROL; SOLVENT MIXTURES; WALL MATERIALS;

ACETONE; ATOMIC FORCE MICROSCOPY; DICHLOROMETHANE; EFFICIENCY; EMULSIFICATION; EMULSIONS; ENCAPSULATION; ETHANOL; EVAPORATION; MOLECULAR WEIGHT; PARTICLE SIZE ANALYSIS; PHASE TRANSITIONS; SOLVENTS;

NANOPARTICLES;

EID: 77949681393     PISSN: 12267708     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Jain RA. The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices. Biomaterials 21: 2475-2490 (2000)
2. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug devices. J. Control. Release 20: 1-20 (2001)
3. Yin J, Noda Y, Yotsuyanagi T. Properties of poly(lactide-co-glycolic acid) nanospheres containing protease inhibitors: Camostat mesilate and nafamostat mesilate. Int. J. Pharm. 314: 46-55 (2006)
4. Chen L, Remondetto GE, Subirade M. Food protein-based materials as nutraceutical delivery systems. Trends Food Sci. Tech. 17: 272- 283 (2006)
5. Verger ML, Fluckiger L, Kim YI, Hoffman M, Maincent P. Preparation and characterization of nanoparticles containing and antihypertensive agent. Eur. J. Pharm. Biopharm. 46: 137-143 (1998)
6. Pérez MH, Zinutti C, Lamprecht A, Ubrich N, Astier A, Hoffman M, Bodmeier R, Maincent P. The preparation and evaluation of poly(ε-caprolactone) microparticles containing both a lipophilic and a hydrophilic drug. J. Control. Release 65: 429-438 (2000)
7. Jiao YY, Ubrich N, Hoffart V, Marchand-Arvier M, Vigneron C, Hoffman M, Maincent P. Preparation and characterization of heparin-loaded polymeric microparticles. Drug Dev. Ind. Pharm. 28: 1033-1041 (2002)
8. Kim BK, Hwang SJ, Park JB, Park HJ. Characteristics of felodipine-locatedpoly(ε-caprolactone)microspheres.J. Microencapsul. 22: 193-203 (2005)
9. Benoit MA, Baras B, Gillard J. Preparation and characterization of protein-loaded poly(ε-caprolactone) microparticles for oral vaccine delivery. Int. J. Pharm. 184: 73-84 (1999)
10. Yang YY, Chung TS, Ng NP. Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/ evaporation method. Biomaterials 22: 231-241 (2001)
11. Chen DR, Bei JZ, Wang SG. Polycaprolactone microparticles and their biodegradation. Polym. Degrad. Stabil. 66: 455-459 (2000)
12. Lamprecht A, Ubrich N, Pérez MH, Lehr CM, Hoffman M, Maincent P. Influence of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int. J. Pharm. 196: 177-182 (2000)
13. Barbato F, Rotonda MIL, Maglio G, Palumbo R, Quaglia F. Biodegradable microspheres of novel segmented poly(ether-ester- amide)s based on poly(ε-caprolactone) for the delivery of bioactive compounds. Biomaterials 22: 1371-1378 (2001)
14. Iooss P, Ray AML, Grimandi G, Daculsi G, Merle C. A new injectable bone substitute combining poly(ε-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials 22: 2785-2794 (2001)
15. Youan BBC, Jacson TL, Dickens L, Hernandez C, Ababio GO. Protein release profiles and morphology of biodegradable microcapsules containing an oily core. J. Control. Release 76: 313- 326 (2001)
16. Siemann EH, Creasy LL. Concentration of the phytoalexin resveratrol in wine. Am. J. Enol. Viticult. 43: 49-52 (1992)
17. Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J,Ungvari Z. Vascular dysfunction in aging: Potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr. Med. Ch em. 13: 989-996 (2006)
18. Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem. 36: 79-87 (2003)
19. Zhao J, Liu CS, Yuan Y, Tao XY, Shan XQ, Sheng Y, Wu F. Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers. Biomaterials 28: 1414-1422 (2007)
20. Viswanathan NB, Thomas PA, Pandit JK, Kulkarni MG, Mashelkar RA. Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique. J. Control. Release 58: 9-20 (1999)
21. Kim BK, Hwang SJ, Park JB, Park HJ. Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method. J. Microencapsul. 19: 811-822 (2002)
22. Herrmann J, Bodmeier R. Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non- aqueous solvent evaporation methods. Eur. J. Pharm. Biopharm. 45: 75-82 (1998)
23. Kawashima Y, Yamamoto H, Takeuchi H, Hino T, Niwa T. Properties of a peptide containing DL-lactide/glycolide copolymer nanospheres prepared by novel emulsion solvent diffusion methods. Eur. J. Pharm. Biopharm. 45: 41-48 (1998)
24. Lamosa MLL, López CR, Jato JLV, Alonso MJ. Design of microencapsulated chitosan microspheres for colonic drug delivery. J. Control. Release 52: 109-118 (1998)
25. Rodriguez M, Jose LV, Torres D. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J. Control. Release 55: 67-77 (1998)
26. Lee JH, Park TG, Choi HK. Effect of formulation and processing variables on the characteristics of microspheres for water soluble drugs prepared by w/o/o double emulsion solvent diffusion method. Int. J. Pharm. 196: 75-83 (2000)
27. Amorim MJLGB, Ferreira JPM. Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine. Eur. J. Pharm. Biopharm. 52: 39-44 (2001)
28. Sah H. Ethyl formate-alternative dispersed solvent useful in preparing PLGA microspheres. Int. J. Pharm. 195: 103-113 (2000)
29. Chernysheva YV, Babak VG, Kildeeva NR, Boury F, Benoit JP, Ubrich N, Maincent P. Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification-solvent evaporation. Mendeleev Commun. 13: 65-67 (2003)