Changes in hippocampal connexin 36 mRNA and protein levels during epileptogenesis in the kindling model of epilepsy

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 3, 2010, Pages 510-515

  Beheshti, Siamak ^a,b   Sayyah, Mohammad ^b   Golkar, Majid ^b   Sepehri, Hoori ^a   Babaie, Jalal ^b   Vaziri, Behrouz ^b  

^a UNIVERSITY OF TEHRAN   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Amygdala kindling; Connexin 36; Epileptogenesis; Hippocampus

Indexed keywords

CONNEXIN 36; CONNEXIN 43; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPILEPSY; EPILEPTOGENESIS; FOCAL EPILEPSY; GENE EXPRESSION REGULATION; GRAND MAL SEIZURE; HIPPOCAMPUS; KINDLING; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION;

AMYGDALA; ANIMALS; CONNEXIN 43; CONNEXINS; DISEASE MODELS, ANIMAL; EPILEPSY; HIPPOCAMPUS; KINDLING, NEUROLOGIC; MALE; RATS; RATS, WISTAR; RNA, MESSENGER; STATISTICS AS TOPIC; UP-REGULATION;

EID: 77949657931     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.02.006     Document Type: Article

References (45)

1. Aronica E., Gorter J.A., Jansen G.H., Leenstra S., Yankaya B., Troost D. Expression of connexin 43 and connexin 32 gap junction proteins in epilepsy-associated brain tumors and in the perilesional epileptic cortex. Acta Neuropathol 2001, 101:449-459.
2. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Seidman J.G., Smith J.A., et al. Short protocols in molecular biology 2002, Wiley.
3. Carlen P.L., Skinner F., Zhang L., Naus C., Kushnir M., Perez Velazquez J.L. The role of gap junctions in seizures. Brain Res Rev 2000, 32:235-241.
4. Collignon F., Wetsen N.M., Cohen-Gadol A.A., Cascino G.D., Parisi J., Meyer F.B., et al. Altered expression of connexin subtypes in mesial temporal lobe epilepsy in humans. J Neurosurg 2006, 105:77-87.
5. Condorelli D.F., Parenti R., Spinella F., Trovato Salino A., Belluardo N., Cardile V. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons. Eur J NeuroSci 1998, 10:1202-1208.
6. Condorelli D.F., Belluardo N., Trovato-salinaro A., Mudo G. Expression of Cx36 in the mammalian neurons. Brain Res Rev 2000, 32:72-85.
7. Condorelli D.F., Trovato-salinaro A., Mudo G., Mirone M.B., Belluardo N. Cellular expression of connexins in the rat brain: neuronal localization, effects of kainite-induced seizures and expression in apoptotic neuronal cells. Eur J NeuroSci 2003, 18:1807-1827.
8. Dichter M.A. Models of epileptogenesis in adult animals available for antiepileptogenesis drug screening. Epilepsy Res 2006, 68:31-35.
9. Dudek F.E., Yasumura T., Rash J.E. Non-synaptic mechanisms in seizures and epileptogenesis. Cell Biol Int 1998, 22:793-805.
10. Elisevich K., Rempel S.A., Smith B., Allar N. Connexin 43 mRNA expression in two experimental models of epilepsy. Mol Chem Neuropathol 1997, 32:75-88.
11. Elisevich K., Rempel S.A., Smith B.J., Edvardsen K. Hippocampal connexin 43 expression in human complex partial seizure disorder. Exp Neurol 1997, 145:154-164.
12. Fisher R., van Emde Boas W., Blume W., Elger C., Genton P., Lee P., et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005, 46:470-472.
13. Fonseca C.G., Green C.R., Nicholson L.F.B. Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy. Brain Res 2002, 929:105-116.
14. Gadja Z., Gyengesi E., Hermesz E., Said Ali K., Szente M. Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo. Epilepsia 2003, 44:1596-1600.
15. Gajda Z., Szupera Z., Blazso G., Szente M. Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo. Epilepsia 2005, 46:1581-1591.
16. Gadja Z., Hermesz E., Gyengesi E., Szupera Z., Szente M. The functional significance of gap junction channels in the epileptogenicity and seizure susceptibility of juvenile rats. Epilepsia 2006, 47:1009-1022.
17. Goddard G.V., McIntyre C.K. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969, 25:295-330.
18. He J., Hsiang H., Wu C., Mylvagnanam S., Carlen P.L., Zhang L. Cellular mechanisms of cobalt-induced hippocampal epileptiform discharges. Epilepsia 2009, 50(1):99-115.
19. Herman S.T. Clinical trials for prevention of epileptogenesis. Epilepsy Res 2006, 68:35-38.
20. Hewapathirane D.S., Burnham W.M. Propagation of amygdala-kindled seizures to the hippocampus in the rat: electroencephalographic features and behavioral correlates. Neurosci Res 2005, 53:369-375.
21. Jahromi S.S., Wentlandt K., Piran S., Carlen P.L. Anticonvulsant actions of gap junctional blockers in an in vitro seizure model. Neurophysiology 2002, 88:1893-1902.
22. Kohling R., Gladwell S.J., Bracci E., Vreugdenhil M., Jefferys J.G. Prolonged epileptiform bursting induced by 0-Mg2+ in rat hippocampal slices depends on gap junctional coupling. Neuroscience 2001, 105:579-587.
23. Khurgel M., Ivy G.O. Astrocytes in kindling: relevance to epileptogenesis. Epilepsy Res 1996, 26:163-175.
24. Li J., Shen C.C.G., Naus L., Zhang L., Carlen P.L. Up regulation of gap junction connexin 32 with epileptiform activity in the isolated mouse hippocampus. Neuroscience 2001, 105:589-598.
25. McNamara J.O., Byrne M.C., Dasheiff R.M., Fitz J.G. The kindling model of epilepsy: a review. Prog Neurobiol 1980, 15:139-159.
26. McCracken C.B., Roberts D.C.S. A single evoked afterdischarge produces rapid time-dependent changes in connexin 36 protein expression in adult rat dorsal hippocampus. Neurosci Lett 2006, 405:84-88.
27. Naus C.C., Bechberger J.F., Paul D.L. Gap junction gene expression in human seizure disorder. Exp Neurol 1991, 111:198-203.
28. Nemani V.M., Binder D.K. Emerging role of gap junctions in epilepsy. Histol Histopathol 2005, 20:253-259.
29. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 2005, Academic Press, New York.
30. Perez-Velazquez J.L., Valiante T.A., Carlen P.L. Modulation mechanisms during calcium-free-induced field burst activity: a possible role for electrotonic coupling in epileptogenesis. J Neurosci 1994, 14:4308-4317.
31. Perez-Velazquez J.L., Carlen P.L. Gap junctions, synchrony and seizure. Trends Neurosci 2000, 23:68-74.
32. Porter R.J., Meldrum B.S. Antiseizure drugs. Basic and Clinical Pharmacology 2001, 395. McGraw-Hill, New York. B.G. Katzun (Ed.).
33. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972, 32:281-294.
34. Racine R.J., Ivy G.O., Milgram N.W. Kindling: clinical relevance and anatomical substrate. The clinical relevance of kindling 1989, 15-34. Wiley, Chichester. T.G. Bolwig, M.R. Trimble (Eds.).
35. Rash J.E., Yasumura T., Davidson K.G.V., Furman C.S., Dudek F.E., Nagy J.I. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Cell Commun Adhes 2001, 8:315-320.
36. Rouach N., Avignone E., Meme W., Koulakoff A., Venance L., Blomstrand F., et al. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell 2002, 94:451-475.
37. Samoilova M., Li J., Pelletier M.R., Wentlandt K., Adamchik Y., Naus C.C., et al. Epileptiform activity in hippocampal slice cultures exposed chronically to bicuculline: increased gap junctional function and expression. J Neurochem 2003, 86:687-699.
38. Samoilova M., Wentlandt K., Adamchik Y., Velumian A.A., Carlen P.L. Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures. Exp Neurol 2008, 210:762-775.
39. Sayyah M., Rezaei M., Haghighi S., Amanzadeh M. Intra-amygdala all-trans retinoic acid inhibits amygdala-kindled seizures in rats. Epilepsy Res 2007, 75:97-103.
40. Sohl G., Guldenagel M., Beck H., Teubner B., Traub O., Gutiervez R. Expression of connexin genes in hippocampus of kainite-treated and kindled rats under conditions of experimental epilepsy. Mol Brain Res 2000, 83:44-51.
41. Sohl G., Maxeiner S., Willecke K. Expression and functions of neuronal gap junctions. Nat Rev Neurosci 2005, 6:191-200.
42. Szente M., Gajda Z., Said Ali K., Hermesz E. Involvement of electrical coupling in the in vivo ictal epileptiform activity induced by 4-Aminopyridine in the neocortex. Neuroscience 2002, 115:1067-1078.
43. Theis M., Sohl G., Speidel D., Kuhn R., Willecke K. Connexin 43 is not expressed in principal cells of mouse cortex and hippocampus. Eur J NeuroSci 2003, 18:267-274.
44. Traub R.D., Whittington M.A., Buhl E.H., LeBeau F.E.N., Bibbig A., Boyd S., et al. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia 2001, 42:153-170.
45. Traub R.D., Draguhn A., Whittington M.A., Bladewag T., Bibbig A., Buhl E.H., et al. Axonal gap junctions between principal neurons: a novel source of network oscillations and perhaps epileptogenesis. Rev Neurosci 2002, 13:1-30.