Epigenetics and the influence of maternal diet

Early Life Origins of Human Health and Disease

Volumn , Issue , 2009, Pages 11-20

  Lillycrop Dr , Karen A ^a   Hanson, Mark A ^b   Burdge, Graham C ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b DOHaD Research Division   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77949595603     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1159/000221149     Document Type: Chapter

References (24)

1. Godfrey KM, Barker DJ: Fetal programming and adult health. Public Health Nutr 2001;4:611-624.
2. Bertram CE, Hanson MA: Animal models and programming of the metabolic syndrome. Br Med Bull 2001;60:103-121.
3. Gluckman PD, Hanson MA: The developmental origins of the metabolic syndrome. Trends Endocrinol Metab 2004;15:183-187.
4. Burdge GC, Phillips ES, Dunn RL, Jackson AA, Lillycrop KA: Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferatoractivated receptors in the liver and adipose tissue of the offspring. Nutr Res 2004;24:639-646.
5. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC: Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005;135:1382-1386.
6. Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21.
7. Fuks F, Hurd PJ, Wolf D, Nan X, Bird AP, Kouzarides T: The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 2003;278:4035-4040.
8. Turner BM: Histone acetylation and an epigenetic code. Bioessays 2002;22:836-845.
9. Gidekel S, Bergman Y: A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cisdemodification element. J Biol Chem 2002;277: 34521-34530.
10. Hershko AY, Kafri T, Fainsod A, Razin A: Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 2003; 302:65-72.
11. Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH: Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the fullterm IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 2003;285:R962-R970.
12. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ: Epigenetic programming by maternal behavior. Nat Neurosci 2004;7:847-854.
13. Paoloni-Giacobino A: Implications of reproductive technologies for birth and developmental outcomes: imprinting defects and beyond. Expert Rev Mol Med 2006;8:1-14.
14. Waterland RA, Michels KB: Epigenetic epidemiology of the developmental origins hypothesis. Ann Rev Nutr 2007;27:363-388.
15. Lillycrop KA, Slater-Jefferies JL, Hanson MA, Godfrey KM, Jackson AA, Burdge GC: Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 2007;97:1064-1073.
16. Lillycrop KA, Phillips ES, Torrens C, Hanson MA, Jackson AA, Burdge GC: Feeding pregnant rats a proteinrestricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR alpha promoter of the offspring. Br J Nutr 2008; 100:278-282.
17. Pembrey ME, Bygren LO, Kaati G, Edvinsson S, Northstone K, Sjostrom M, Golding J, ALSPAC Study Team: Sex-specific, maleline transgenerational responses in humans. Eur J Hum Genet 2006;14:159-166.
18. Painter RC, Roseboom TJ, Bleker OP: Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol 2005;20:345-352.
19. Torrens C, Brawley L, Dance CS, Itoh S, Poston L, Hanson MA: First evidence for transgenerational vascular programming in the rat protein restriction model. J Physiol 2002;543:41P-42P.
20. Burdge GC, Slater-Jefferies J, Torrens C, Phillips ES, Hanson MA, Lillycrop KA: Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr 2007;97:435-439.
21. Jackson AA, Dunn RL, Marchand MC, Langley-Evans SC: Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond) 2002;103:633-639.
22. James SJ, Melnyk S, Pogribna M, Pogribny IP, Caudill MA: Elevation in Sadenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 2002;132(suppl 8):2361S-2366S.
23. Petrie L, Duthie SJ, Rees WD, McConnell JM: Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming. Br J Nutr 2002;88:471-477.
24. Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R: Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat Genet 2001;27:31-39.