Usefulness of Clopidogrel to Protect Against Diabetes-Induced Vascular Damage

American Journal of Cardiology

Volumn 105, Issue 7, 2010, Pages 1014-1018

  McClung, John A ^a   Kruger, Adam L ^a   Ferraris, Ambra ^a   Vanella, Luca ^a   Tsenovoy, Petr ^a   Weiss, Melvin B ^a   Abraham, Nader G ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ACETYLSALICYLIC ACID; ACRIDINE ORANGE; ADENOSINE KINASE; ADENOSINE MONOPHOSPHATE KINASE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CD133 ANTIGEN; CD146 ANTIGEN; CD34 ANTIGEN; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EZETIMIBE; FIBRIC ACID DERIVATIVE; INCRETIN; INSULIN; METFORMIN; PROTEIN KINASE B; PROTON PUMP INHIBITOR; SILDENAFIL; SULFONYLUREA DERIVATIVE; THIAZIDE DIURETIC AGENT; UNCLASSIFIED DRUG; WARFARIN;

ADULT; AGED; ARTICLE; BLOOD; BLOOD SAMPLING; BLOOD VESSEL INJURY; CELL COUNT; CELL ISOLATION; CLINICAL ARTICLE; DIABETIC PATIENT; EX VIVO STUDY; FEMALE; FLUORESCENCE MICROSCOPY; HEART PROTECTION; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL; TREATMENT DURATION; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

ADULT; AGED; CELL COUNT; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; VASCULAR DISEASES;

EID: 77949561423     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.11.034     Document Type: Article

References (30)

1. Steinhubl S.R., Badimon J.J., Bhatt D.L., Herbert J., and Luscher T.F. Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease. Vasc Med 12 (2007) 133-122
2. Ziemianin B., Olszanecki R., Uracz W., Marcinkiewicz E., and Gryglewski R.J. Thienopyridines: effects on cultured endothelial cells. J Physiol Pharmacol 50 (1999) 597-604
3. Vishnevetsky D., Kiyanista V.A., and Gandhi P.J. CD40 ligand: a novel target in the fight against cardiovascular disease. Ann Pharmacother 38 (2004) 1500-1508
4. Hancock W.W., Buelow R., Sayegh M.H., and Turka L.A. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 4 (1998) 1392-1396
5. McClung J.A., Naseer N., Saleem M., Rossi G.P., Weiss M.B., and Abraham N.G. Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independent of HbA1c. Diabetologia 48 (2005) 345-350
6. Abraham N.G., Kushida T., McClung J., Weiss M., Quan S., Lafaro R., Darzynkiewicz Z., and Wolin M. Heme oxygenase-1 attentuates glucose mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Circ Res 93 (2003) 507-514
7. Mutin M., Canavy I., Blann A., Bory M., Sampol J., and Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood 93 (1999) 2951-2958
8. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., Zeiher A.M., and Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 89 (2001) E1-E7
9. Smadja D.M., Gaussem P., Mauge L., Israel-Biet D., Dignat-George F., Peyrard S., Agnoletti G., Vouhe P.R., Bonnet D., and Levy M. Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease. Circulation 119 (2009) 374-381
10. Erdbruegger U., Haubitz M., and Woywodt A. Circulating endothelial cells: a novel marker of endothelial damage. Clin Chim Acta 373 (2006) 17-26
11. Holmen C., Elsheikh E., Stenvinkel P., Qureshi A.R., Pettersson E., Jalkanen S., and Sumitran-Holgersson S. Circulating inflammatory endothelial cells contribute to endothelial progenitor cell dysfunction in patients with vasculitis and kidney involvement. J Am Soc Nephrol 16 (2005) 3110-3120
12. Dimmeler S., Assmus B., Hermann C., Haendeler J., and Zeiher A.M. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res 83 (1998) 334-342
13. Fulton D., Gratton J.P., McCabe T.J., Fontana J., Fujio Y., Walsh K., Franke T.F., Papapetropoulos A., and Sessa W.C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 (1999) 597-601
14. Morales-Ruiz M., Fulton D., Sowa G., Languino L.R., Fujio Y., Walsh K., and Sessa W.C. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ Res 86 (2000) 892-896
15. Dimmeler S., Aicher A., Vasa M., Mildner-Rihm C., Adler K., Tiemann M., Rutten H., Fichtlscherer S., Martin H., and Zeiher A.M. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinae/Akt pathway. J Clin Invest 108 (2001) 391-397
16. Ido Y., Carling D., and Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes 51 (2002) 159-167
17. Wang Y., Gao E., Tao L., Lau W.B., Yuan Y., Goldstein B.J., Lopez B.L., Christopher T.A., Tian R., Koch W., and Ma X.L. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation 119 (2009) 835-844
18. Xu J., and Zou M. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 120 (2009) 1266-1286
19. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., and Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 (1999) 601-605
20. Chen Z.P., Mitchelhill K.I., Michell B.J., Michell B.J., Stapleton D., Rodriguez-Crespo I., Witters L.A., Power D.A., Ortiz de Montellano P.R., and Kemp B.E. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 443 (1999) 285-289
21. Thum T., Fraccarollo D., Schultheiss M., Froese S., Galuppo P., Widder J.D., Tsikas D., Ertl G., and Bauersachs J. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes 56 (2007) 666-674
22. Aicher A., Heeschen C., Mildner-Rihm C., Urbich C., Ihling C., Technau-Ihling K., Zeiher A.M., and Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9 (2003) 1370-1376
23. Sambuceti G., Morbelli S., Vanella L., Kusmic C., Marini C., Massollo M., Augeri C., Corselli M., Ghersi C., Chiavarina B., Rodella L.F., L'Abbate A., Drummond G., and Abraham N.G. Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage; reversed by increases in pAMPK, heme oxygenase-1 and adiponectin. Stem Cells 27 (2009) 399-407
24. Jakubowski A., Chlopicki S., Olszanecki R., Jawien J., Lomnicka M., Dupin J.P., and Gryglewski R.J. Endothelial action of thienopyridines and thienopyrimidinones in the isolated guinea pig heart. Prostaglandins Leukot Essent Fatty Acids 72 (2005) 139-145
25. Warnholtz A., Ostad M.A., Velich N., Trautmann C., Schinzel R., Walter U., and Munzel T. A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Atherosclerosis 196 (2008) 689-695
26. Din J., Sarma J., Harding S.A., Fox K.A.A., Newby D.E., and Macioca P. Clopidogrel regulates platelet, leukocyte, and endothelial interactions in type 2 diabetes mellitus. J Am Coll Cardiol 43 Suppl A (2004) 444A
27. Angiolillo D.J., Fernandez-Oritz A., Bernardo E., Ramirez C., Sabate M., Jimenez-Ouevedo P., Hernandez R., Moreno R., Escaned J., Alfonso F., Banuelos C., Costa M.A., Bass T.A., and Macaya C. Clopidogrel withdrawal is associated with proinflammatory and prothrombotic effects in patients with diabetes and coronary artery disease. Diabetes 55 (2006) 780-784
28. Bhatt D.L., Marso S.T., Hirsch A.T., Ringleb P.A., Hacke W., and Topol E.J. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am J Cardiol 90 (2002) 625-628
29. Takakusa H., Masumoto H., Mitsuru A., Okazaki O., and Sudo K. Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drub Metab Dispos 36 (2008) 816-823
30. Shanker G., Kontos J.L., Eckman D.M., Wesley-Farrington D., and Sane D.C. Nicotine upregulates the expression of the P2Y12 on vascular cells and megakaryoblasts. J Thromb Thrombolysis 22 (2006) 213-220