Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL) methyl]Uracil, TPI(F): An inhibitor of human thymidine phosphorylase (TP)

Nucleosides, Nucleotides and Nucleic Acids

Volumn 29, Issue 1, 2010, Pages 49-54

  Grierson, John R ^a   Brockenbrough, J Scott ^a   Rasey, Janet S ^a   Wiens, Linda ^a   Vesselle, Hubert ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Human thymidine phosphorylase; TP; TPI; TPI(F); Transition state inhibitor analog

Indexed keywords

5 FLUORO 6 [(2 IMINOPYRROLIDIN 1 YL)METHYL]URACIL; RADIOPHARMACEUTICAL AGENT; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE; 5-FLUORO-6-((2-IMINOPYRROLIDIN-1-YL)METHYL)URACIL; ENZYME INHIBITOR; PYRROLIDINE DERIVATIVE; THYMIDINE; URACIL;

ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO CULTURE; INHIBITION KINETICS; POSITRON EMISSION TOMOGRAPHY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CATALYSIS; CHEMISTRY; DRUG EFFECTS; HUMAN; IC50; METABOLISM; SYNTHESIS;

CATALYSIS; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; PYRROLIDINES; THYMIDINE; THYMIDINE PHOSPHORYLASE; URACIL;

EID: 77949549501     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903451603     Document Type: Article

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