Antidepressant fluoxetine suppresses neuronal growth from both vertebrate and invertebrate neurons and perturbs synapse formation between Lymnaea neurons

European Journal of Neuroscience

Volumn 31, Issue 6, 2010, Pages 994-1005

  Xu, Fenglian ^a   Luk, Collin ^a   Richard, Maria P ^a   Zaidi, Wali ^a   Farkas, Svetlana ^a   Getz, Angela ^a   Lee, Arthur ^a   Van Minnen, Jan ^a   Syed, Naweed I ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cholinergic; Cortical; Cytoskeleton; Intracellular Ca2+; Pedal A

Indexed keywords

CALCIUM; FLUOXETINE;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CALCIUM CELL LEVEL; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; CYTOSKELETON; GROWTH CONE; INVERTEBRATE; LYMNAEA; NERVE CELL GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE CELL; SPINAL GANGLION; SYNAPSE; SYNAPTIC TRANSMISSION; TISSUE REGENERATION; VERTEBRATE;

ACTINS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; GROWTH CONES; LYMNAEA; MICROSCOPY, CONFOCAL; NEURAL INHIBITION; NEURITES; NEURONS; RATS; SYNAPTIC TRANSMISSION;

EID: 77949543721     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2010.07129.x     Document Type: Article

References (50)

1. Aimone, J.B., Wiles, J. Gage, F.H. (2009) Computational influence of adult neurogenesis on memory encoding. Neuron, 61, 187 202.
2. Anderson, L., Anderson, P., Anderson, T., Bishop, A. Anderson, J. (2009) Effects of selective serotonin reuptake inhibitors on motor neuron survival. Int. J. Gen. Med., 2, 109 115.
3. Bianchi, M., Shah, A.J., Fone, K.C., Atkins, A.R., Dawson, L.A., Heidbreder, C.A., Hows, M.E., Hagan, J.J. Marsden, C.A. (2009) Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus. Synapse, 63, 359 364.
4. Bulloch, A.G. Hauser, G.C. (1990) Sprouting by isolated Helisoma neurons: enhancement by glutamate. Int. J. Dev. Neurosci., 8, 391 398.
5. Cameron, H.A. McKay, R.D. (2001) Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol., 435, 406 417.
6. Craig, A.M., Graf, E.R. Linhoff, M.W. (2006) How to build a central synapse: clues from cell culture. Trends Neurosci., 29, 8 20.
7. Damluji, R. Riley, P.A. (1979) On the role of calcium in adhesion of cells to solid substrates. Exp. Cell Biol., 47, 226 237.
8. Feng, Z.P., Klumperman, J., Lukowiak, K. Syed, N.I. (1997) In vitro synaptogenesis between the somata of identified Lymnaea neurons requires protein synthesis but not extrinsic growth factors or substrate adhesion molecules. J. Neurosci., 17, 7839 7849.
9. Fiumara, F., Leitinger, G., Milanese, C., Montarolo, P.G. Ghirardi, M. (2005) In vitro formation and activity-dependent plasticity of synapses between Helix neurons involved in the neural control of feeding and withdrawal behaviors. Neuroscience, 134, 1133 1151.
10. Gallo, G. Letourneau, P.C. (2004) Regulation of growth cone actin filaments by guidance cues. J. Neurobiol., 58, 92 102.
11. Gaspar, P., Cases, O. Maroteaux, L. (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat. Rev. Neurosci., 4, 1002 1012.
12. Gomez, T.M. Zheng, J.Q. (2006) The molecular basis for calcium-dependent axon pathfinding. Nat. Rev. Neurosci., 7, 115 125.
13. Hajszan, T., MacLusky, N.J. Leranth, C. (2005) Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. Eur. J. Neurosci., 21, 1299 1303.
14. Hamakawa, T., Woodin, M.A., Bjorgum, M.C., Painter, S.D., Takasaki, M., Lukowiak, K., Nagle, G.T. Syed, N.I. (1999) Excitatory synaptogenesis between identified Lymnaea neurons requires extrinsic trophic factors and is mediated by receptor tyrosine kinases. J. Neurosci., 19, 9306 9312.
15. 2+ signals. Trends Cell Biol., 14, 320 330.
16. Homberg, J.R., Schubert, D. Gaspar, P. (2010) New perspectives on the neurodevelopmental effects of SSRIs. Trends Pharmacol. Sci., 31, 60 65.
17. 2+ induces macropinocytosis via F-actin depolymerization during growth cone collapse. Mol. Cell. Neurosci., 40, 27 38.
18. 2+]i with fluorescent indicators. Methods Cell Biol., 40, 155 181.
19. Karson, C.N., Newton, J.E., Livingston, R., Jolly, J.B., Cooper, T.B., Sprigg, J. Komoroski, R.A. (1993) Human brain fluoxetine concentrations. J. Neuropsychiatry Clin. Neurosci., 5, 322 329.
20. Kater, S.B. Mills, L.R. (1991) Regulation of growth cone behavior by calcium. J. Neurosci., 11, 891 899.
21. Kee, N., Teixeira, C.M., Wang, A.H. Frankland, P.W. (2007) Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat. Neurosci., 10, 355 362.
22. Kyriakides, M., McCrohan, C.R., Slade, C.T., Syed, N.I. Winlow, W. (1989) The morphology and electrophysiology of the neurones of the paired pedal ganglia of Lymnaea stagnalis (L.). Comp. Biochem. Physiol. A Comp. Physiol., 93, 861 876.
23. Lankford, K.L. Letourneau, P.C. (1989) Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments. J. Cell Biol., 109, 1229 1243.
24. Lenkey, N., Karoly, R., Kiss, J.P., Szasz, B.K., Vizi, E.S. Mike, A. (2006) The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine. Mol. Pharmacol., 70, 2052 2063.
25. Letourneau, P.C., Condic, M.L. Snow, D.M. (1992) Extracellular matrix and neurite outgrowth. Curr. Opin. Genet. Dev., 2, 625 634.
26. Lledo, P.M. (2009) Dissecting the pathophysiology of depression with a Swiss army knife. Neuron, 62, 453 455.
27. Maertens, C., Wei, L., Voets, T., Droogmans, G. Nilius, B. (1999) Block by fluoxetine of volume-regulated anion channels. Br. J. Pharmacol., 126, 508 514.
28. Malberg, J.E., Eisch, A.J., Nestler, E.J. Duman, R.S. (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci., 20, 9104 9110.
29. Mattson, M.P. Kater, S.B. (1987) Calcium regulation of neurite elongation and growth cone motility. J. Neurosci., 7, 4034 4043.
30. Maya Vetencourt, J.F., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., O'Leary, O.F., Castren, E. Maffei, L. (2008) The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science, 320, 385 388.
31. Munno, D.W., Woodin, M.A., Lukowiak, K., Syed, N.I. Dickinson, P.S. (2000) Different extrinsic trophic factors regulate neurite outgrowth and synapse formation between identified Lymnaea neurons. J. Neurobiol., 44, 20 30.
32. Neely, M.D. Gesemann, M. (1994) Disruption of microfilaments in growth cones following depolarization and calcium influx. J. Neurosci., 14, 7511 7520.
33. Nishiyama, M., von Schimmelmann, M.J., Togashi, K., Findley, W.M. Hong, K. (2008) Membrane potential shifts caused by diffusible guidance signals direct growth-cone turning. Nat. Neurosci., 11, 762 771.
34. Ridgway, R.L., Syed, N.I., Lukowiak, K. Bulloch, A.G. (1991) Nerve growth factor (NGF) induces sprouting of specific neurons of the snail, Lymnaea stagnalis. J. Neurobiol., 22, 377 390.
35. Saito, S., Radwan, I.A., Nishikawa, K., Obata, H., Okamoto, T., Kanno, T. Goto, F. (2004) Intracellular calcium increases in growth cones exposed to tetracaine. Anesth. Analg., 98, 841 845. table of contents.
36. Spafford, J.D., Dunn, T., Smit, A.B., Syed, N.I. Zamponi, G.W. (2006) In vitro characterization of L-type calcium channels and their contribution to firing behavior in invertebrate respiratory neurons. J. Neurophysiol., 95, 42 52.
37. Spencer, G.E., Lukowiak, K. Syed, N.I. (2000) Transmitter-receptor interactions between growth cones of identified Lymnaea neurons determine target cell selection in vitro. J. Neurosci., 20, 8077 8086.
38. Sung, M.J., Ahn, H.S., Hahn, S.J. Choi, B.H. (2008) Open channel block of Kv3.1 currents by fluoxetine. J. Pharmacol. Sci., 106, 38 45.
39. Syed, N.I., Zaidi, H. Lovell, P. (1999) In vitro reconstruction of neuronal circuits: a simple model system approach. In Windhurst, U. Johansson, H. (eds Modern Techniques in Neuroscience Research. Springer, Berlin, pp. 361 377.
40. Traboulsie, A., Chemin, J., Kupfer, E., Nargeot, J. Lory, P. (2006) T-type calcium channels are inhibited by fluoxetine and its metabolite norfluoxetine. Mol. Pharmacol., 69, 1963 1968.
41. Tuccori, M., Testi, A., Antonioli, L., Fornai, M., Montagnani, S., Ghisu, N., Colucci, R., Corona, T., Blandizzi, C. Del Tacca, M. (2009) Safety concerns associated with the use of serotonin reuptake inhibitors and other serotonergic/noradrenergic antidepressants during pregnancy: a review. Clin. Ther., 31, 1426 1453.
42. Tytgat, J., Maertens, C. Daenens, P. (1997) Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1). Br. J. Pharmacol., 122, 1417 1424.
43. US Food and Drug Administration (2006) Prozac Prescribing Information. http://www.accessdata.fda.gov/drugsatfda-docs/label/2006/018936s0761b1.pdf, pp. 35.
44. Vicario-Abejon, C., Collin, C., McKay, R.D. Segal, M. (1998) Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. J. Neurosci., 18, 7256 7271.
45. Welnhofer, E.A., Zhao, L. Cohan, C.S. (1999) Calcium influx alters actin bundle dynamics and retrograde flow in Helisoma growth cones. J. Neurosci., 19, 7971 7982.
46. Woodin, M.A., Hamakawa, T., Takasaki, M., Lukowiak, K. Syed, N.I. (1999) Trophic factor-induced plasticity of synaptic connections between identified Lymnaea neurons. Learn Mem., 6, 307 316.
47. Woodin, M.A., Munno, D.W. Syed, N.I. (2002) Trophic factor-induced excitatory synaptogenesis involves postsynaptic modulation of nicotinic acetylcholine receptors. J. Neurosci., 22, 505 514.
48. Xu, F., Hennessy, D.A., Lee, T.K. Syed, N.I. (2009) Trophic factor-induced intracellular calcium oscillations are required for the expression of postsynaptic acetylcholine receptors during synapse formation between Lymnaea neurons. J. Neurosci., 29, 2167 2176.
49. Zhao, C., Deng, W. Gage, F.H. (2008) Mechanisms and functional implications of adult neurogenesis. Cell, 132, 645 660.
50. Zheng, J.Q. Poo, M.M. (2007) Calcium signaling in neuronal motility. Annu. Rev. Cell Dev. Biol., 23, 375 404.