Unresponsiveness to interferon associated with STAT1 protein deficiency in a gastric adenocarcinoma cell line

Cancer Immunology Immunotherapy

Volumn 47, Issue 2, 1998, Pages 113-120

  Abril, E ^a   Real, L M ^a   Serrano, A ^a   Jimenez, P ^a   Garcia A ^a   Canton, J ^a   Trigo, I ^a   Garrido, F ^a   Ruiz Cabello, F ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

Gene expression; Interferon response elements; Promoter; Transcriptional factors

Indexed keywords

INTERFERON; TRANSCRIPTION FACTOR;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; GENE EXPRESSION REGULATION; GENE INDUCTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; TRANSCRIPTION REGULATION;

ADENOCARCINOMA; DNA, NEOPLASM; DNA-BINDING PROTEINS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTERFERON ALFA-2A; INTERFERON TYPE II; NEOPLASM PROTEINS; STAT1 TRANSCRIPTION FACTOR; STOMACH NEOPLASMS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0031659236     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050511     Document Type: Article

References (38)

1. Abril E, Mendez RE, García A, Serrano A, Cabrera T, Garrido F, Ruiz-Cabello, F (1996) Characterization of a gastric tumor cell line defective in MHC class I inducibility by both α- and γ-interferon. Tissue Antigens 47:391
2. Bodmer WF, Browning MJ, Krausa P, Rowan A, Bicknell DC, Bodmer JG (1993) Tumor escape from immune response by variation in HLA expression and other mechanisms. Ann NY Acad Sci 690:42
3. Burke PA, Hirschfeld S, Shirayoshi Y, Kasis JW, Hamada K, Apella E, Ozato, K (1989) Developmental and tissue specific expression of nuclear proteins that bind the regulatory element of the major histocompatibility complex class I gene. J Exp Med 169:1309
4. Chin YE, Kitagawa M, Su WC, You ZH, Fu XY (1996) Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1 CIP1 mediated by STAT1. Science 272:719
5. Chu G, Hayakawa H, Berg P (1987) Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res 15:1311
6. Darnell JE, Kerr I, Stark R (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415
7. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475
8. Durbin JE, Hackenmiller R, Simon MC, Levy DF (1996) Targeted disruption of the mouse Stat 1 gene results in compromised innate immunity to viral disease. Cell 84:443
9. Fu XY, Kessler DS, Veals SA, Levy DE, Darnell, JE (1990) ISGF-3, the transcriptional activator induced by IFN-α, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci USA 87:8555
10. Fu XY, Schindler C, Improta T, Aebersold R, Darnell JE (1992) The protein of ISGF-3, the interferon-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci USA 89:7840
11. Garrido F, Ruiz-Cabello F (1991) MHC expression on human tumors. Its relevance for local tumor growth and metastasis. Semin Cancer Biol 2:3
12. Garrido F, Cabrera T, Concha A, Glew S, Ruiz-Cabello F, Stern P (1993) Natural history of HLA expression during tumour development. Immunol Today 14:491
13. Garrido F, Cabrera T, Lopez-Nevot MA, Ruiz-Cabello F (1995) HLA class I antigens in human tumors. Adv Cancer Res 67:155
14. Garrido F, Ruiz-Cabello F, Cabrera T, Perez-Villar JJ, Lopez-Botet M, Duggan-Keen M, Stern PL (1997) Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol Today 18:89
15. Ghislain JJ, Fish EN (1996) Application of genomic DNA affinity chromatography identifies multiple interferon-alpha-regulated Stat2 complexes. J Biol Chem 271:12408
16. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O (1995) Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 13:369
17. Israël A, Kimura A, Fournie A, Fellous M, Kourilsky P (1986) Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H-2 gene. Nature 322:743
18. Jule E, Mucke L, Oldstone MBA (1991) Viral persistence m neurons explained by lack of major histocompatibility class I expression. Science 253:1283
19. Lethonen A, Matikainen S, Julkunen I (1997) Interferons up-regulate STA1, STAT2 and IRF family transcription factor gene expression in human peripheral blood mononucler cells and macrophages. J Immunol 159:794
20. Levy DE, Darnell JE (1990) Interferon-dependent transcriptional activation: signal transduction without second messenger involvement? New Biol 2:923
21. Levy DE, Lew DJ, Decker T, Kessler DS, Darnell JE (1990) Synergistic interaction between interferon alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J 9:1105
22. McKendry R, John J, Flavell D, Muller M, Kerr IM, Stark GR (1991) High frequency mutagenesis of human cells and characterization of a mutant unresponsive to both and interferons. Proc Natl Acad Sci USA 88:11455
23. Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD (1996) Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway. Cell 84:431
24. Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur, AG, Barbier G, Witthuhn BA, Schindler C, Pellegrini S, Wilks AF, Ihle JN, Stark GR, Kerr IM (1993) The protein tyrosine kinase JAK1 complements a mutant cell line defective in the interferon-α β and -γ signal transduction pathways. Nature 366:129
25. Mullet M, Laxton C, Briscoe J, Schindlet C, Improta T, Darnell JE, Stark GR, Kerr M (1993) Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways. EMBO J 12:4221
26. Nordeen SK (1988) Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 6:454
27. Pellegrini S, John J, Shearer M, Kerr IM, Stark GR (1989) Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol 9:4605
28. Pine R, Canova A, Schindler C (1994) Tyrosine phosphorylated p91 binds to a single element en the ISGF2/IRF1 promoter to mediate induction by IFN and IFN, and is likely to autoregulate the p91 gene. EMBO J 13:158
29. Ploegh H, Orr H, Strominger J (1981) Major histocompatibility antigens: the human (HLA-A, B, C) and murine (H-2K, H-2D) class I molecules. Cell 24:287
30. + T cells against the wild-type tumor: correlation with antigen presentation capability. J Exp Med 175:1423
31. Rodriguez F, Peran F, Garrido F, Ruiz-Cabello F (1994) Up-modulation by estrogen of HLA class I expression in breast tumor cell lines. Immunogenetics 39:161
32. Shirayoshi Y, Burke PA, Appella E, Ozato K (1988) Interferon-induced transcription of a major histocompatibility class I gene accompanies hinding of inducible nuclear factors to the interferon consensus sequence. Proc Natl Acad Sci USA 85:5884
33. Shuai K, Schindler C, Prezioso VR, Darnell JE (1992) Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258:1808
34. Shuai K, Stark GR, Kerr IM, Darnell JE (1993) A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ. Science 261:1744
35. Sugita K, Miyazaki JI, Appella E, Ozato K (1987) Interferon increases transcription of a major histocompatibility class I gene via a 5′ interferon consensus sequence. Mol Cell Biol 7:2625
36. Svane IM, Engel AM, Nielsen M, Wederlin O (1997) Interferon-gamma-induced MHC class I expression and defects in Jak/Stat signalling in methyleholanthrene-induced sarcomas. Scand J Immunol 46:379
37. Trinchieri G (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptative immunity. Annu Rev Immunol 13:251
38. Wong LH, Krauer KG, Hatzinisiriou I, Estcourt MJ, Hersey P, Tam ND, Edmonson S, Devenish RJ, Ralph SJ (1997) Interferon-resistant human melanoma cells are deficient in ISGF3 components, STAT1, STA2; and p48-ISGF3 gamma. J Immunol 272:28779