Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway

Cell Growth and Differentiation

Volumn 10, Issue 4, 1999, Pages 263-270

  Percario, Zulema A ^b   Giandomenico, Valeria ^b   Fiorucci, Gianna ^a   Chiantore, Maria V ^a   Vannucchi, Serena ^a   Hiscott, John ^c   Affabris, Elisabetta ^a,b   Romeo, Giovanna ^a,d  

^a CNR   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c MCGILL UNIVERSITY   (Canada)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; RETINOIC ACID; STAT1 PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; DNA SEQUENCE; GENE INDUCTION; GENE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; DACTINOMYCIN; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INTERFERON ALFA-2B; INTERFERON REGULATORY FACTOR-1; NF-KAPPA B; PHOSPHOPROTEINS; PROTEIN SYNTHESIS INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TRANS-ACTIVATORS; TRANSFECTION; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0032947898     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Harada, H., Willison, K., Sakakibara, J., Miyamoto, M., Fujita, T., and Taniguchi, T. Absence of the type I IFN system in EC cells: transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated. Cell, 63: 303-312, 1990.
2. Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., and Taniguchi, T. Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements. Cell, 54: 903-913, 1988.
3. Tanaka, N., Kawakami, T., and Taniguchi, T. Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol., 13: 4531-4538, 1993.
4. Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., and Taniguchi, T. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell, 58: 729-739, 1989.
5. Abdollahi, A., Lord, K. A., Hoffman-Liebermann, B., and Liebermann, D. Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition. Cell Growth Differ., 2: 401-407, 1991.
6. Fujita, T., Reis, L. F. L., Watanabe, N., Kimura, Y., Taniguchi, T., and Vilcek, J. Induction of the transcription factor IRF-1 and interferon β mRNAs by cytokines and activators of second-messenger pathways. Proc. Natl. Acad. Sci. USA, 86: 9936-9940, 1989.
7. Pine, R., Decker, T., Kessler, D. S., Levy, D. E., and Darnell, J. E. Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both β interferon-and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol. Cell. Biol., 10: 2448-2457, 1990.
8. Willman, C. L., Sever, C. E., Pallavicini, M. G., Harada, H., Tanaka, N., Slovak, M. L., Yamamoto, H., Harada, K., Meeker, T. C., List, A. F., et al. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science (Washington DC), 259: 968-971, 1993.
9. Yu-Lee, L-Y., Hrachovy, J. A., Stevens, A. M., and Schwarz, L. A. Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells. Mol. Cell. Biol., 10: 3087-3094, 1990.
10. Kanno, Y., Kozak, C. A., Schindler, C., Driggers, P. H., Ennist, D. L., Gleason, S. L., Darnell, J. J. E., and Ozato, K. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 α subunit (or similar) molecule binds. Mol. Cell. Biol., 13: 3951-3963, 1993.
11. Sims, S. H., Cha, Y., Romine, M. F., Gao, P-Q., Gottlieb, K., and Deisseroth, A. B. A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol. Cell. Biol., 13: 690-702, 1993.
12. IhIe, J. N. STATs: signal transducers and activators of transcription. Cell, 84: 331-334, 1996.
13. Darnell, J. E., Kerr, I., and Stark, G. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (Washington DC), 264: 1415-1421, 1994.
14. Taniguchi, T. 1995. Cytokine signaling through nonreceptor protein tyrosine kinases. Science (Washington DC), 268: 251-255.
15. Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., and Taniguchi, T. Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and 2. Science (Washington DC), 259: 971-974, 1993.
16. Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., and Taniguchi, T. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell, 77: 829-839, 1994.
17. Harada, H., Kondo, T., Ogawa, S., Tamura, T., Kitagawa, M., Tanaka, N., Lamphier, M. S., Hirai, H., and Taniguchi, T. Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia: a possible mechanism of tumor suppressor inactivation. Oncogene, 9: 3313-3320, 1993.
18. Watanabe, N., Sakakibara, J., Hovanessian, A., Taniguchi, T., and Fujita, T. Activation of IFN-β element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis. Nucleic Acids Res., 16: 4421-4428, 1991.
19. Sonenberg, N. Translation factors as effectors of cell growth and tumorigenesis. Curr. Opin. Cell Biol., 5: 955-960, 1993.
20. Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., and Taniguchi, T. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (Lond.), 376: 596-599, 1995.
21. Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., and Taniguchi, T. Cooperation of the tumor suppressor IRF-1 and p53 in response to DNA damage. Nature (Lond.), 382: 816-818, 1996.
22. Giandomenico, V., Lancillotti, F., Fiorucci, G., Percario, Z. A., Rivabene, R., Malomi, W., Affabris, E., and Romeo, G. Retinoic acid and IFN inhibition of cell proliferation is associated with apoptosis in squamous carcinoma cell lines: role of IRF-1 and TGase II-dependent pathways. Cell Growth Differ., 8: 91-100, 1997.
23. Gudas, L. J., Sporn, M. B., and Roberts, A. B. The Retinoids: Biology, Chemistry and Medicine. In: M. B. Sporn, A. B. Roberts, and D. S. Goodman (eds.), Ed. 2, pp. 443-520. New York: Raven Press, Ltd., 1994.
24. Chambon, P. The molecular and genetic dissection of the retinoid signaling pathway. Recent Prog. Horm. Res., 50: 317-332, 1995.
25. 3, and analogs. J. Cell. Biochem., 56: 427-435, 1994.
26. Kolla, V., Lindner, D. J., Weihua, X., Borden, E. C., and Kalvakolanu, D. V. Modulation of Interferon (IFN)-inducible gene expression by retinoic acid. Up-regulation of STAT1 protein in IFN-unresponsive cells. J. Biol. Chem., 271: 10508-10514, 1996.
27. Lancillotti, F., Giandomenico, V., Affabris, E., Fiorucci, G., Romeo, G., and Rossi, G. B. Interferon α-2b and retinoic acid combined treatment affects proliferation and gene expression of human cervical carcinoma cells. Cancer Res., 55: 3158-3164, 1995.
28. Lippman, S. M., Glisson, B. M., Kavanagh, J. J., Lotan, R., Hong, W. K., Peredes-Espinoza, M., Hittelman, W. N., Holdener, E. E., and Krakoff, I. H. Retinoc acid and interferon combination studies in human cancer. Eur. J. Cancer, 29A: S9-S13, 1993.
29. Giandomenico, V., Vaccari, G., Fiorucci, G., Percario, Z., Vannucchi, S., Matarrese, P., Malomi, W., Romeo, G., and Affabris, E. Apoptosis and growth inhibition of squamous carcinoma cells treated with IFN-α, IFN-β and retinoic acid are associated with induction of the cyclin-dependent kinase inhibitor p21. Eur. Cytokine Net., in press, 1999.
30. Harada, H., Takahashi, E-I., Itoh, S., Harada, K., Hori, T-A., and Taniguchi, T. Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system. Mol. Cell. Biol., 14: 1500-1509, 1994.
31. McDonnell, T. J. Cell division versus cell death: a functional model of multistep neoplasia. Mol. Carcinog., 8: 209-213, 1993.
32. Gianni, M., Terao, M., Fortino, I., LiCalzi, M., Viggiano, V., Barbui, T., Rambaldi, A., and Garattini, E. Stat1 induced and activated by all-trans retinoic acid in acute promyelocytic leukemia cells. Blood, 89: 1001-1012, 1997.
33. Matikainen, S., Ronni, T., Hurme, M., Pine, R., and Julkunen, I. Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood, 88: 114-123, 1996.
34. Baeuerle, P.A., and Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol., 12: 141-179, 1994.
35. Lin, R., Gewert D., and Hiscott, J. Differential transcriptional activation in vitro by NF-κB/rel proteins. J. Biol. Chem., 270: 3123-3131, 1995.
36. Roulston, A., Lin, R., Beauparlant, P., Wainberg, M., and Hiscott, J. Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-κB/rel transcription factors. Microbiol. Rev., 59: 481-505, 1992.
37. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., Jr., and Levy, D. E. Subunit of an α-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol. Cell. Biol., 12: 3315-3324, 1992.
38. Perkins, N. D., Schmid, R. M., Duckett, C. S., Leung, K., Rice, N. R., and Nabel, G. J. Distinct combinations of NF-κB subunits determine the specificity of transcriptional activation. Proc. Natl. Acad. Sci. USA, 89: 1529-1533, 1992.
39. Pelicano, L., Li, F., Schindler, C., and Chelbi-Alix, M. K. Retinoic acid enhances the expression of interferon-induced proteins: evidence for multiple mechanisms of action. Oncogene, 15: 2349-2359, 1997.
40. Romeo, G., and Affabris, E. Retinoic acid and interferon induced apoptosis. Retinoids Today Tomorrow, 45: 32-35, 1996.
41. Bluyssen, H. A. R., Durbin, J. E., and Levy, D. E. ISGF3 gamma p48, a specificity switch for interferon activated transcription factors. Cytokine Growth Factor Rev., 7: 11-17, 1996.
42. Glisin, V., Crkvenjakov, R., and Byus, C. Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry, 13: 2633-2637, 1974.
43. Pine, R., Canova, A., and Schindler, C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN α and IFN γ, and is likely to autoregulate the p91 gene. EMBO J., 13: 158-167, 1994.
44. Coccia, E. M., Vaiman, D., Raber, J., Marziali, G., Fiorucci, G., Orsatti, R., Cohen, B., Nissim, N., Romeo, G., Affabris, E., Chebath, J., and Battistini, A. Protein binding to the interferon response enhancer correlates with interferon induction of 2′,5′-oligoadenylate synthethase in normal and interferon-resistant Friend cells. J. Virol., 65: 2081-2087, 1991.
45. Fried, M., and Crothers, D. M. Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acid Res., 9: 6505-6525, 1981.