Kinetics and regional specificity of irinotecan-induced gene expression in the gastrointestinal tract

Toxicology

Volumn 269, Issue 1, 2010, Pages 1-12

  Bowen, J M ^a,b   Tsykin, Anna ^a,c   Stringer, Andrea M ^a,b   Logan, Richard M ^a,d   Gibson, Rachel J ^a   Keefe, Dorothy M K ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c HANSON INSTITUTE   (Australia)

^d Division of Surgical Pathology   (Australia)

Author keywords

Gastrointestinal damage; Irinotecan; Microarray; Mucositis; Rat

Indexed keywords

BIOLOGICAL MARKER; CELL MARKER; IRINOTECAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; PROTEIN P105; CAMPTOTHECIN; DRUG DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COLON INJURY; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; INFLAMMATION; INTESTINE INJURY; JEJUNUM; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; STOMACH INJURY; TISSUE SPECIFICITY; TOXICITY TESTING; TRANSCRIPTION REGULATION; UPREGULATION; WOUND HEALING; ANIMAL; COMPARATIVE STUDY; DNA MICROARRAY; DRUG EFFECT; GASTROINTESTINAL TRACT; METABOLISM; METHODOLOGY; PATHOLOGY;

RATTUS;

ANIMALS; CAMPTOTHECIN; FEMALE; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; SIGNAL TRANSDUCTION;

EID: 77949538551     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.12.020     Document Type: Article

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