Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection

BMB Reports

Volumn 42, Issue 12, 2009, Pages 834-839

  Chun, Ji Yong ^a   Bae, Joon Seol ^a   Park, Tae June ^a   Kim, Jason Y ^a   Park, Byung Lae ^b   Cheong, Hyun Sub ^b   Lee, Hyo Suk ^c   Kim, Yoon Jun ^c   Shin, Hyoung Doo ^a,b  

^a Sogang University   (South Korea)

^b SNP Genetics Inc   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Chronic hepatitis (CH); DNA methyltransferase (DNMT); Hepatitis B virus (HBV); Hepatocellular carcinoma (HCC); Liver cirrhosis (LC); Polymorphism

Indexed keywords

HEPATITIS B VIRUS;

EID: 77949535168     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2009.42.12.834     Document Type: Article

References (44)

1. Purcell, R. H. (1993) The discovery of the hepatitis viruses. Gastroenterology 104, 955-963.
2. Lok, A. S., Heathcote, E. J. and Hoofnagle, J. H. (2001) Management of hepatitis B: 2000-summary of a workshop. Gastroenterology 120, 1828-1853.
3. Thursz, M. (2001) Genetic susceptibility in chronic viral hepatitis. Antiviral. Res. 52, 113-116.
4. Gama-Sosa, M. A., Slagel, V. A., Trewyn, R. W., Oxenhandler, R., Kuo, K. C., Gehrke, C. W. and Ehrlich, M. (1983) The 5-methylcytosine content of DNA from human tumors. Nucleic. Acids. Res. 11, 6883-6894.
5. Vachtenheim, J., Horakova, I. and Novotna, H. (1994) Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer. Cancer Res. 54, 1145-1148.
6. Yoshiura, K., Kanai, Y., Ochiai, A., Shimoyama, Y., Sugimura, T. and Hirohashi, S. (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. U.S.A. 92, 7416-7419.
7. Eguchi, K., Kanai, Y., Kobayashi, K. and Hirohashi, S. (1997) DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history. Cancer Res. 57, 4913-4915.
8. Kanai, Y., Ushijima, S., Ochiai, A., Eguchi, K., Hui, A. and Hirohashi, S. (1998) DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis. Cancer Lett. 122, 135-141.
9. Shen, J. C., Rideout, W. M., 3rd and Jones, P. A. (1992) High frequency mutagenesis by a DNA methyltransferase. Cell 71, 1073-1080.
10. Makos, M., Nelkin, B. D., Reiter, R. E., Gnarra, J. R., Brooks, J., Isaacs, W., Linehan, M. and Baylin, S. B. (1993) Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors. Cancer Res. 53, 2719-2722.
11. Chen, R. Z., Pettersson, U., Beard, C., Jackson-Grusby, L. and Jaenisch, R. (1998) DNA hypomethylation leads to elevated mutation rates. Nature 395, 89-93.
12. Baylin, S. B., Esteller, M., Rountree, M. R., Bachman, K. E., Schuebel, K. and Herman, J. G. (2001) Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum. Mol. Genet. 10, 687-692.
13. Jones, P. A. and Baylin, S. B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428.
14. Robertson, K. D. (2002) DNA methylation and chromatinunraveling the tangled web. Oncogene 21, 5361-5379.
15. Robertson, K. D. (2001) DNA methylation, methyltransferases, and cancer. Oncogene 20, 3139-3155.
16. Garinis, G. A., Patrinos, G. P., Spanakis, N. E. and Menounos, P. G. (2002) DNA hypermethylation: when tumour suppressor genes go silent. Hum. Genet. 111, 115-127.
17. Nephew, K. P. and Huang, T. H. (2003) Epigenetic gene silencing in cancer initiation and progression. Cancer Lett. 190, 125-133.
18. Lee, S., Lee, H. J., Kim, J. H., Lee, H. S., Jang, J. J. and Kang, G. H. (2003) Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am. J. Pathol. 163, 1371-1378.
19. Yang, B., Guo, M., Herman, J. G. and Clark, D. P. (2003) Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am. J. Pathol. 163, 1101-1107.
20. Saito, Y., Kanai, Y., Sakamoto, M., Saito, H., Ishii, H. and Hirohashi, S. (2001) Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33, 561-568.
21. Kondo, Y., Kanai, Y., Sakamoto, M., Mizokami, M., Ueda, R. and Hirohashi, S. (2000) Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis-A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology 32, 970-979.
22. Ishiguro, A., Takahata, T., Saito, M., Yoshiya, G., Tamura, Y., Sasaki, M. and Munakata, A. (2006) Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer. J. Gastroenterol. Hepatol. 21, 1334-1339.
23. Roncalli, M., Bianchi, P., Bruni, B., Laghi, L., Destro, A., Di Gioia, S., Gennari, L., Tommasini, M., Malesci, A. and Coggi, G. (2002) Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. Hepatology 36, 427-432.
24. Bestor, T., Laudano, A., Mattaliano, R. and Ingram, V. (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol. 203, 971-983.
25. Okano, M., Xie, S. and Li, E. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 19, 219-220.
26. Jung, J. K., Arora, P., Pagano, J. S. and Jang, K. L. (2007) Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res. 67, 5771-5778.
27. Liu, X., Xu, Q., Chen, W., Cao, H., Zheng, R. and Li, G. (2009) Hepatitis B virus DNA-induced carcinogenesis of human normal liver cells by virtue of nonmethylated CpG DNA. Oncol. Rep. 21, 941-947.
28. Chen, T. and Li, E. (2004) Structure and function of eukaryotic DNA methyltransferases. Curr. Top. Dev. Biol. 60, 55-89.
29. Oh, B. K., Kim, H., Park, H. J., Shim, Y. H., Choi, J., Park, C. and Park, Y. N. (2007) DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. Int. J. Mol. Med. 20, 65-73.
30. Lin, C. H., Hsieh, S. Y., Sheen, I. S., Lee, W. C., Chen, T. C., Shyu, W. C. and Liaw, Y. F. (2001) Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res. 61, 4238-4243.
31. Bestor, T. H. (1992) Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. Embo. J. 11, 2611-2617.
32. Chuang, L. S., Ian, H. I., Koh, T. W., Ng, H. H., Xu, G. and Li, B. F. (1997) Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277, 1996-2000.
33. Saito, Y., Kanai, Y., Nakagawa, T., Sakamoto, M., Saito, H., Ishii, H. and Hirohashi, S. (2003) Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. Int. J. Cancer 105, 527-532.
34. Bruix, J., Sherman, M., Llovet, J. M., Beaugrand, M., Lencioni, R., Burroughs, A. K., Christensen, E., Pagliaro, L., Colombo, M. and Rodes, J. (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J. Hepatol. 35, 421-430.
35. Livak, K. J. (1999) Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet. Anal. 14, 143-149.
36. Hedrick, P. and Kumar, S. (2001) Mutation and linkage disequilibrium in human mtDNA. Eur. J. Hum. Genet. 9, 969-972.
37. Barrett, J. C., Fry, B., Maller, J. and Daly, M. J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
38. Stephens, M., Smith, N. J. and Donnelly, P. (2001) A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978-989.
39. Bae, S. H., Yoon, S. K., Jang, J. W., Kim, C. W., Nam, S. W., Choi, J. Y., Kim, B. S., Park, Y. M., Suzuki, S., Sugauchi, F. and Mizokami, M. (2005) Hepatitis B virus genotype C prevails among chronic carriers of the virus in Korea. J. Korean Med. Sci. 20, 816-820.
40. Odgerel, Z., Nho, K. B., Moon, J. Y., Kee, S. H., Park, K. S., Song, K. J., Baek, L. J., Yeon, J. E., Byun, K. S., Lee, C. H. and Song, J. W. (2003) Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolates from patients with chronic HBV infection in Korea. J. Med. Virol. 71, 499-503.
41. Song, B. C., Cui, X. J. and Kim, H. (2005) Hepatitis B virus genotypes in Korea: an endemic area of hepatitis B virus infection. Intervirology 48, 133-137.
42. Song, B. C., Kim, H., Kim, S. H., Cha, C. Y., Kook, Y. H. and Kim, B. J. (2005) Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea. J. Med. Virol. 75, 13-19.
43. Yoo, B. C., Park, J. W., Kim, H. J., Lee, D. H., Cha, Y. J. and Park, S. M. (2003) Precore and core promoter mutations of hepatitis B virus and hepatitis B e antigen-negative chronic hepatitis B in Korea. J. Hepatol. 38, 98-103.
44. Nyholt, D. R. (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 74, 765-769.