Protective effect of PEGylation against poly(amidoamine) dendrimer-induced hemolysis of human red blood cells

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 93, Issue 1, 2010, Pages 59-64

  Wang, Wei ^a   Xiong, Wei ^a   Zhu, Yanhong ^a   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Atomic force microscopy; Hemolysis; Poly(amidoamine) dendrimers; Poly(ethylene glycol); RBC

Indexed keywords

AFM; CELL LYSIS; HEMATOLOGIC TOXICITY; HEMOCOMPATIBILITY; HUMAN RED BLOOD CELL; IN-VIVO; PAMAM DENDRIMER; PEGYLATION; POLYAMIDOAMINE DENDRIMERS; POSITIVELY CHARGED SURFACES; PROTECTIVE EFFECTS; RED BLOOD CELL;

ATOMIC FORCE MICROSCOPY; ATOMS; BLOOD; CELL MEMBRANES; CYTOLOGY; DENDRIMERS; ETHYLENE; ETHYLENE GLYCOL; HEMOGLOBIN OXYGEN SATURATION; MEDICAL APPLICATIONS; OPTICAL MICROSCOPY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SURFACE MORPHOLOGY; SURFACE ROUGHNESS;

FUNCTIONAL POLYMERS;

MACROGOL; POLYAMIDOAMINE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD COMPATIBILITY; CELL PROTECTION; CELL SURFACE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOLYSIS; ERYTHROCYTE; ERYTHROCYTE AGGREGATION; ERYTHROCYTE SHAPE; HEMOLYSIS; HUMAN; HUMAN CELL; MICROSCOPY; MORPHOLOGY; NORMAL HUMAN; PEGYLATION;

BIOCOMPATIBLE MATERIALS; DENDRIMERS; ERYTHROCYTE AGGREGATION; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HEMOLYSIS; HUMANS; MATERIALS TESTING; MICROSCOPY, ATOMIC FORCE; POLYETHYLENE GLYCOLS; SURFACE PROPERTIES;

EID: 77949533769     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31558     Document Type: Article

References (34)

1. Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, Ryder J, Smith P. A new class of polymers: Starburst-dendritic macromolecules. Polym J 1985;17:117-132.
2. Mammen M, Choi SK, Whitesides GM. Polyvalent interactionsin biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed Engl 1998;37:2754-2794.
3. Yang W, Cheng Y, Xu T, Wang X, Wen LP. Targeting cancer cells with biotin-dendrimer conjugates. Eur J Med Chem 2009;44:862-868.
4. Dribek M, Le Potier I, Rodrigues A, Pallandre A, Fattal E, Taverna M. Determination of binding constants of vasoactive intestinal peptide to poly(amidoamine) dendrimers designed for drug delivery using ACE. Electrophoresis 2007;28:2191-2200.
5. Majoros IJ, Myc A, Thomas T, Mehta CB, Baker JR Jr. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: Synthesis, characterization, and functionality. Biomacromolecules 2006;7:572-579.
6. Wu G, Barth RF, Yang W, Kawabata S, Zhang L, Green-Church K. Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates. Mol Cancer Ther 2006;5:52-59.
7. Kubát P, Lang K, Janda P, Anzenbacher P Jr. Interaction of porphyrins with a dendrimer template: Self-aggregation controlled by pH. Langmuir 2005;21:9714-9720.
8. Majoros IJ, Thomas TP, Mehta CB, Baker JR Jr. Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy. J Med Chem 2005;48:5892-5899.
9. Dung TH, Kim J, Kim MS, Kim JS, Yoo H. Preparation and biophysical characterization of pluronic F127-dendrimer conjugate as a delivery agent of antisense oligonucleotides. J Nanosci Nanotechnol 2008;8:5326-5330.
10. Kang H, DeLong R, Fisher MH, Juliano RL. Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides. Pharm Res 2005;22:2099-2106.
11. Swanson SD, Kukowska-Latallo JF, Patri AK, Chen C, Ge S, Cao Z, Kotlyar A, East AT, Baker JR. Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int J Nanomed 2008;3:201-210.
12. Lebdusková P, Sour A, Helm L, Tóth E, Kotek J, Lukes I, Merbach AE. Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: An 17O and 1H relaxation study of its Gd(III) complex. Dalton Trans 2006;28:3399-3406.
13. Wang W, Guo Z, Chen Y, Liu T, Jiang L. Influence of generation 2-5 of PAMAM dendrimer on the inhibition of Tat peptide/TAR RNA binding in HIV-1 transcription. Chem Biol Drug Des 2006;68:314-318.
14. Kobayashi H, Kawamoto S, Bernardo M, Brechbiel MW, Knopp MV, Choyke PL. Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: Comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging. J Control Release 2006;111:343-351.
15. Rekas A, Lo V, Gadd GE, Cappai R, Yun SI. PAMAM dendrimers as potential agents against fibrillation of alpha-synuclein, a Parkinson's disease-related protein. Macromol Biosci 2009;9:230-238.
16. Roberts JC, Bhalgat MK, Zera RT. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. J Biomed Mater Res 1996;30:53-65.
17. 125I-labelled polyamidoamine dendrimers in vivo. J Control Release 2000; 65:133-148.
18. Dománski DM, Klajnert B, Bryszewska M. Influence of PAMAM dendrimers on human red blood cells. Bioelectro-chemistry 2004;63:189-191.
19. Mendiratta S, Qu ZC, May JM. Erythrocyte ascorbate recycling: Antioxidant effects in blood. Free Radic Biol Med 1998;24:789-797.
20. Wang W, Xiong W, Wan J, Sun X, Xu H, Yang X. The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxidative stress. Nanotechnology 2009;20:105103.
21. Zobel HP, Stieneker F, Atmaca-Abdel Aziz S, Gilbert M, Werner D, Noe CR, Kreuter J, Zimmer A. Evaluation of amino-alkylmethacrylate nanoparticles as colloidal drug carrier systems. II. Characterization of antisense oligonucleotides loaded copolymer nanoparticles. Eur J Pharm Biopharm 1999;48:1-12.
22. Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 2005;57:2215-2237.
23. Li J, Xiao H, Li J, Zhong Y. Drug carrier systems based on water-soluble cationic beta-cyclodextrin polymers. Int J Pharm 2004;278:329-342.
24. Fischer D, von Harpe A, Kunath K, Petersen H, Li Y, Kissel T. Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes. Bioconjugate Chem 2002;13:1124-1133.
25. Elgsaeter A, Mikkelsen A. Shapes and shape changes in vitro in normal red blood cells. Biochim Biophys Acta 1991;1071: 273-290.
26. Bennett V. The membrane skeleton of human erythrocytes and its implications for more complex cells. Ann Rev Biochem 1985;54:273-304.
27. Suwalsky M, Fierro P, Villena F, Sotomayor C. Effects of lithium on the human erythrocyte membrane and molecular models. Biophys Chem 2007;129:36-42.
28. Girasole M, Pompeo G, Cricenti A, Congiu-Castellano A, Andreola F, Serafino A, Frazer BH, Boumis G, Amiconi G. Roughness of the plasma membrane as an independent morphological parameter to study RBCs: A quantitative atomic force microscopy investigation. Biochim Biophys Acta 2007; 1768:1268-1276.
29. Belcheva N, Woodrow-Mumford K, Mahoney MJ, Saltzman WM. Synthesis and biological activity of polyethylene glycolmouse nerve growth factor conjugate. Bioconjugate Chem 1999;10:932-937.
30. Yoshida Y, Kashiba K, Niki E. Free radical-mediated oxidation of lipids induced by hemoglobin in aqueous dispersions Biochim Biophys Acta 1994;1201:165-172.
31. Zhang TL, Gao YX, Lu JF, Wang K. Arsenite, arsenate and vanadate affect human erythrocyte membrane. J Inorg Biochem 2000;79:195-203.
32. Jevprasesphant R, Penny J, Jalal R, Attwood D, McKeown NB, D'Emanuele A. The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int J Pharm 2003; 252:263-266.
33. Mao S, Neu M, Germershaus O, Merkel O, Sitterberg J, Bakowsky U, Kissel T. Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjugate Chem 2006;17:1209-1218.
34. Luo D, Haverstick K, Belcheva N, Han E, Saltzman WM. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible, high-efficiency DNA delivery. Macromolecules 2002;35:3456-3462.