Aflatoxin exposure and impaired child growth in West Africa: An unexplored international public health burden

Mycotoxins: Detection Methods, Management, Public Health and Agricultural Trade

Volumn , Issue , 2008, Pages 53-65

  Gong, Yun Yun ^a   Turner, Paul C ^a   Hall, Andrew J ^b   Wild, Christopher P ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77949518859     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (58)

1. Allen, S.J., Wild, C.P., Wheeler, J.G., Riley, E.M., Montesano, R., Bennett, S., Whittle, H.C. and Hall, A.J. (1992) Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 86, 426-430.
2. Azziz-Baumgartner, E., Lindblade, K., Gieseker, K., Rogers, H.S., Kieszak, S., Njapau, H., Schleicher, R., McCoy, L.F., Misore, A., DeCock, K., Rubin, C. and Slutsker, L. (2005) Case-control study of an acute aflatoxicosis outbreak, Kenya. Environmental Health Perspectives 113, 1779-1783.
3. Barker, D.J. (2002) Fetal programming of coronary heart disease. Trends in Endocrinology and Metabolism 13, 364-368.
4. Black, R.E., Morris, S.S. and Bryce, J. (2003) Where and why are 10 million children dying every year. The Lancet 361, 2226-2234.
5. Bouhet, S. and Oswald, I.P. (2005) The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Veterinary Immunology and Immunopathology 108, 199-209.
6. Bryce, J., Boschi-Pinto, C., Shibuya, K. and Black, R.E. (2005) WHO estimates of the causes of death in children. The Lancet 365, 1147-1152.
7. Campbell, D.I., Lunn, P.G. and Elia, M. (2002) Age-related association of small intestinal mucosal enteropathy with nutritional status in rural Gambian children. British Journal of Nutrition 88, 499-505.
8. Campbell, D.I., Elia, M. and Lunn, P.G. (2003a) Growth faltering in rural Gambian infants is associated with impaired small intestinal barrier function, leading to endotoxemia and systemic inflammation. Journal of Nutrition 133, 1332-1338.
9. Campbell, D.I., Murch, S.H., Elia, M., Sullivan, P.B., Sanyang, M.S., Jobarteh, B. and Lunn, P.G. (2003b) Chronic T cell-mediated enteropathy in rural West African children: Relationship with nutritional status and small bowel function. Pediatric Research 54, 306-311.
10. Campbell, D.I., McPhail, G., Lunn, P.G., Elia, M. and Jeffries, D.J. (2004) Intestinal inflammation measured by fecal neopterin in Gambian children with enteropathy: Association with growth failure, Giardia lamblia, and intestinal permeability. Journal of Pediatric Gastroenterology and Nutrition 39, 153-157.
11. Caulfield, L.E., de Onis, M., Blössner, M. and Black, R.E. (2004a) Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria and measles. American Journal of Clinical Nutrition 80, 193-198.
12. Caulfield, L.E., Richard, S.A. and Black, R.E. (2004b) Undernutrition as an underlying cause of malaria morbidity and mortality in children less than five years old. American Journal of Tropical Medicine and Hygiene 71 (suppl. 2), 55-63.
13. Cusumano. V., Rossano, F., Merendino, R.A., Arena, A., Costa, G.B., Mancuso, G., Baroni, A. and Losi, E. (1996) Immunobiological activities of mould products: Functional impairment of human monocytes exposed to aflatoxin B1. Review of Microbiology 147, 385-391.
14. Denning, D.W. (1987) Aflatoxin and human disease. Adverse Drug Reaction and Acute Poisoning Review 6, 175-209.
15. Dersjant-Li, Y., Verstegen, M.W.A. and Gerrits, W.J.J. (2003) The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry. Nutrition Research Reviews 16, 223-239.
16. Diallo, M.S., Sylla, A., Sidibé, K., Sylla, B.S., Trepo, C.R. and Wild, C.P. (1995) Prevalence of exposure to aflatoxin and hepatitis B and C viruses in Guinea, West Africa. Natural Toxins 3, 6-9.
17. Edrington, T.S., Harvey, R.B. and Kubena, L.F. (1995) Toxic effects of aflatoxin B1 and ochratoxin A, alone and in combination, on chicken embryos. Bulletin of Environmental Contamination and Toxicology 54, 331-336.
18. Finch, C.E. and Crimmins, E.M. (2004) Inflammatory exposure and historical changes in human lifespans. Science 305, 1736-1739.
19. Gong, Y.Y., Cardwell, K., Hounsa, A., Egal, S., Turner, P.C., Hall, A.J. and Wild, C.P. (2002) Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo, West Africa: Cross sectional study. British Medical Journal 325, 20-21.
20. Gong, Y.Y., Egal, S., Hounsa, A., Turner, P.C., Hall, A.J., Cardwell, K.F. and Wild, C.P. (2003) Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: The critical role of weaning. International Journal of Epidemiology 32, 556-562.
21. Gong, Y.Y., Hounsa, A., Egal, S., Turner, P.C., Sutcliffe, A.E., Hall, A.J., Cardwell, K. and Wild, C.P. (2004) Post-weaning exposure to aflatoxin results in impaired child growth: A longitudinal study in Benin, West Africa. Environmental Health Perspectives 112, 1334-1338.
22. Gratz, S., Wu, Q.K., El-Nezami, H., Juvonen, R.O., Mykkänen, H. and Turner, P.C. (2007) Alteration of intestinal transport, metabolism and toxicity of aflatoxin B1 by Lactobacillus rhamnosus strain GG in vitro in Caco-2 cells. Applied and Environmental Microbiology 73, 3958-3964.
23. Groopman, J.D. and Kensler, T.W. (1999) The light at the end of the tunnel for chemical-specific biomarker: Daylight or headlight. Carcinogenesis 20, 1-11.
24. Guengerich, F.P., Johnson, W.W., Shimada, T., Ueng, Y.F., Yamazaki, H. and Langouet, S. (1998) Activation and detoxification of aflatoxin B1. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 402, 121-128.
25. Hall, A.J. and Wild, C.P. (1994) Epidemiology of aflatoxin-related disease. In: Eaton, D.A. and Groopman, J.D. (eds.) The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance. Academic Press, San Diego, California. pp. 233-258.
26. Hendrickse, R.G.J.B., Coulter, S.M., Lamplugh, S.B., Macfarlane, S.B.J., Williams, T.E., Omer, M.I.A. and Suliman, G.I. (1982) Aflatoxins and Kwashiorkor: A study in Sudanese children. British Medical Journal 285, 843-846.
27. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2002) Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 82, 1-556.
28. Jiang, Y., Jolly, P.E., Ellis, W.O., Wang, J.S., Phillips, T.D. and Williams, J.H. (2005) Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. International Immunology 17, 807-814.
29. Lunn, P.G. (2000) The impact of infection and nutrition on gut function and growth in childhood. Proceedings of the Nutrition Society 59, 147-154.
30. Lunn, P.G. (2002) Growth retardation and stunting of children in developing countries - Invited commentary. British Journal of Nutrition 88, 109-110.
31. Lunn, P.G., Northro-Clewes, C.A. and Downes, R.M. (1991) Intestinal permeability, mucosal injury, and growth faltering in Gambian infants. The Lancet 338, 907-910.
32. Marin, D.E., Taranu, I., Bunaciu, R.P., Pascale, F., Tudor, D.S., Avram, N., Sarca, M., Cureu, I., Criste, R.D., Suta, V. and Oswald, I.P. (2002) Changes in performance, blood parameters, humoral and cellular immune responses in weanling piglets exposed to low doses of aflatoxin. Journal of Animal Science 80, 1250-1257.
33. McLaughlin, J., Padfield, P.J., Burt, J.P.H. and O'Neill, C.A. (2004) Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms. American Journal of Physiology Cell Physiology 287, C1412-C1417.
34. Northrop-Clewes, C.A., Lunn, P.G. and Downes, R.M. (1997) Lactose maldigestion in breast-feeding Gambian infants. Journal of Pediatric Gastroenterology and Nutrition 24, 257-263.
35. Paine, M.F., Hart, H.L., Ludington, S.S., Haining, R.L., Rettie, A.E. and Zeldin, D.C. (2006) The human intestinal cytochrome P450 "pie". Drug Metabolism and Disposition 34, 880-886.
36. Pier, A.C. and McLoughlin, M.E. (1985) Mycotoxic suppression of immunity. In: Lacey, J. (ed.) Tricothecenes and Other Mycotoxins. John Wiley, New York, pp. 507-519.
37. Prentice, A. (1993) Nutrient requirements for growth, pregnancy and lactation: The Keneba experience. South African Journal of Clinical Nutrition 6, 33-38.
38. Rossano, F., DeLuna, L.O., Buommino, E., Cusumano, V., Losi, E. and Catania, M.R. (1999) Secondary metabolites of Aspergillus exert immunobiological effects on human monocytes. Research in Microbiology 150, 13-19.
39. Sim, S.C., Edwards, R.J., Boobis, A.R. and Ingelman-Sundberg, M. (2005) CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele. Pharmacogenetics and Genomics 15, 625-631.
40. Smith, E.E., Kubena, L.F., Braithwaite, R.B., Harvey, R.B., Phillips, T.D. and Reine, A.H. (1992) Toxicological evaluation of aflatoxin and cyclopiazonic acid in broiler chickens. Poultry Science 71, 1136-1144.
41. Strosnider, H., Azziz-Baumgartner, E., Banziger, M., Bhat, R.V., Breiman, R., Brune, M.N., DeCock, K., Dilley, A., Groopman, J., Hell, K., Henry, S.H., Jeffers, D., Jolly, C., Jolly, P., Kibata, G. N., Lewis, L., Liu, X., Luber, G., McCoy, L., Mensah, P., Miraglia, M., Misore, A., Njapau, H., Ong, C-N., Onsongo, M.T.K., Page, S.W., Park, D., Patel, M., Phillips, T., Pineiro, M., Pronczuk, J., Schurz Rogers, H., Rubin, C., Sabino, M., Schaafsma, A., Shephard , G., Stroka, J., Wild, C.P., Williams, J.T. and Wilson, D. (2006) Public health strategies for reducing aflatoxin exposure in developing countries: a workgroup report. Environmental Health Perspectives 114, 1898-1903.
42. Thomson, A.B.R., Drozdowski, L., Iordache, C., Thomson, B.K.A., Vermeire, S., Clandinin, M.T. and Wild, G. (2003) Small bowel review - Normal physiology, part 1. Digestive Diseases and Sciences 48, 1546-1564.
43. Turner, P.C., Mendy, M., Whittle, H., Fortuin, M., Hall, A.J. and Wild, C.P. (2000) Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Tropical Medicine and International Health 5, 837-841.
44. Turner, P.C., Moore, S.E. Hall, A.J., Prentice, A.M. and Wild, C.P. (2003) Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environmental Health Perspectives 111, 217-220.
45. Turner, P.C., Sylla, A., Gong, Y.Y., Diallo, M.S., Sutcliffe, A.E., Hall, A.J. and Wild, C.P. (2005a) Reduction in exposure to carcinogenic aflatoxins by postharvest intervention measures in West Africa: a community-based intervention study. The Lancet 365, 1950-1956.
46. Turner, P.C., Sylla, A., Kuang, S-Y., Marchant, C.L., Diallo, M.S., Hall, A.J., Groopman, J.D. and Wild, C.P. (2005b) Absence of TP53 codon 249 mutations in Guinean infants with high aflatoxin exposure. Cancer Epidemiology, Biomarkers & Prevention 14, 2053-2055.
47. Turner P.C., Collinson A.C., Cheung Y.B., Gong Y.Y., Hall A.J., Prentice A.M. and Wild C.P. (2007) Aflatoxin exposure in utero causes growth faltering in Gambian infants. International Journal of Epidemiology 36, 1119-1125.
48. UNEP GEO-2000. http://www.unep.org/Geo2000/english/i56b.htm
49. Van Egmond, H.P. and Jonker, M.A. (2004) Worldwide regulations on aflatoxins - The situation in 2002. Journal of Toxicology-Toxin Review 23, 273-293.
50. Whitaker, T.B. (2006) Sampling foods for mycotoxins. Food Additives and Contaminants 23, 50-61.
51. Wild, C.P. and Hall, A.J. (2000) Primary prevention of hepatocellular carcinoma in developing countries. Mutation Research 462, 381-393.
52. Wild, C.P. and Turner, P.C. (2002) The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis 17, 471-481.
53. Wild, C.P., Fortuin, M., Donato, F., Whittle, H.C., Hall, A.J., Wolf, C.R. and Montesano, R. (1993) Aflatoxin, liver enzymes and hepatitis B virus infection in Gambian children. Cancer Epidemiology, Biomarkers & Prevention 2, 555-561.
54. Wild, C.P., Rasheed, F.N., Jawla, M.F. Hall, A.J., Jansen, L.A. and Montesano, R. (1991) In utero exposure to aflatoxin in West Africa. The Lancet 337, 1602.
55. Wild, C.P., Yin, F., Turner, P.C., Chemin, I., Chapot, B., Mendy, M., Whittle, H., Kirk, G.D. and Hall, A.J. (2000) Environmental and genetic determinants of aflatoxin-albumin adducts in The Gambia. International Journal of Cancer 86, 1-7.
56. Williams, J.H., Phillips, T.D., Jolly, P.E., Stiles, J.K., Jolly, C.M. and Aggarwal, D. (2004) Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. American Journal of Clinical Nutrition 80, 1106-1122.
57. Wojnowski, L., Turner, P.C., Pedersen, B., Hustert, E., Brockmoller, J., Whittle, H.C., Kirk, G. and Wild, C.P. (2004) Increased levels of aflatoxins-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. Pharmacogenetics 14, 691-700.
58. Wu, F. (2004) Mycotoxin risk assessment for the purpose of setting international regulatory standards. Environmental Science and Technology 38, 4049-4055.