Vitamin B deficiency causes neural cell loss and cognitive impairment in the developing rat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 1, 2009, Pages

  Daval, Jean Luc ^a   Blaise, Sébastien ^a   Guéant, Jean Louis ^a,b  

^a INSERM   (France)

^b OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ASTROCYTE; COGNITIVE DEFECT; DISEASE ASSOCIATION; IMMUNOHISTOCHEMISTRY; LETTER; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; VITAMIN DEFICIENCY;

ANIMALS; COGNITION DISORDERS; HIPPOCAMPUS; NEURONS; RATS; VITAMIN B DEFICIENCY;

RATTUS;

EID: 58549095250     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809217106     Document Type: Letter

References (5)

1. Troen AM, et al. (2008) B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci USA 105:12474-12479.
2. Blaise SA, et al. (2007) Gestational vitamin B deficiency leads to homocysteine-associated brain apoptosis and alters neurobehavioral development in rats. Am J Pathol 170:667-679.
3. Kronenberg G, et al. (2008) Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. J Neurosci 28:7219-7230.
4. Rabaneda LG, et al. (2008) Homocysteine inhibits proliferation of neuronal precursors in the mouse adult brain by impairing the basic fibroblast growth factor signaling cascade and reducing extracellular regulated kinase 1/2-dependent cyclin E expression. FASEB J 22:3823-3835.
5. Kruman II, Mouton PR, Emokpae R, Jr, Cutler RG, Mattson MP (2005) Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport 16:1055-1059.