Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders

American Journal of Psychiatry

Volumn 160, Issue 1, 2003, Pages 76-82

  Kegeles, Lawrence S ^a,b   Malone, Kevin M ^a,b   Slifstein, Mark ^a,b   Ellis, Steven P ^a,b   Xanthopoulos, Eric ^a,b   Keilp, John G ^a,b   Campbell, Carl ^a,b   Oquendo, Maria ^a,b   Van Heertum, Ronald L ^a,b   John Mann, J ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FENFLURAMINE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; PLACEBO;

ADULT; AGE DISTRIBUTION; ANALYTIC METHOD; ARTICLE; BIPOLAR DISORDER; BRAIN METABOLISM; BRAIN REGION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; FAMILIAL DISEASE; FAMILY HISTORY; FEMALE; GENDER; GLUCOSE METABOLISM; HUMAN; IMAGE ANALYSIS; IMAGING; MAJOR DEPRESSION; MALE; METABOLISM; MOOD DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; VOLUMETRY; VOLUNTEER;

ADULT; AFFECT; BIPOLAR DISORDER; BLOOD GLUCOSE; BRAIN MAPPING; DEPRESSIVE DISORDER, MAJOR; ENERGY METABOLISM; FEMALE; FENFLURAMINE; FLUORODEOXYGLUCOSE F18; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; SEROTONIN; TOMOGRAPHY, EMISSION-COMPUTED; TREATMENT OUTCOME;

EID: 0037228030     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.1.76     Document Type: Article

References (38)

1. Soares JC, Mann JJ: The functional neuroanatomy of mood disorders. J Psychiatr Res 1997; 31:393-432
2. Soares JC, Mann JJ: The anatomy of mood disorders - Review of structural neuroimaging studies. Biol Psychiatry 1997; 41:86-106
3. Mann JJ, Malone KM, Diehl DJ, Perel J, Cooper TB, Mintun MA: Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am J Psychiatry 1996; 153:174-182; correction, 153:588
4. Drevets WC, Price JL, Simpson JR, Todd RD, Reich T, Vannier M, Raichle ME: Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997; 386:824-827
5. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK,Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT: Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness. Am J Psychiatry 1999; 156:675-682
6. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD: Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry 2002; 51:342-344
7. Bremner JD, Vythilingam M, Vermetten E, Nazeer A, Adil J, Khan S, Staib LH, Charney DS: Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry 2002; 51:273-279
8. Brambilla P, Nicoletti MA, Sassi RB, Frank E, Kupfer DJ, Keshavan MS, Soares JC: Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar disorder patients (abstract). Biol Psychiatry 2002; 51:138S
9. Nobler MS, Sackeim HA, Prohovnik I, Moeller JR, Mukherjee S, Schnur DB, Prudic J, Devanand DP: Regional cerebral blood flow in mood disorders, III: Treatment and clinical response. Arch Gen Psychiatry 1994; 51:884-897
10. Nobler MS, Oquendo MA, Kegeles LS, Malone KM, Campbell C, Sackeim HA, Mann JJ: Decreased regional brain metabolism after ECT. Am J Psychiatry 2001; 158:305-308
11. George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P, Post RM: Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry 1995; 152:341-351
12. Gemar MC, Kapur S, Segal ZV, Brown GM, Houle S: Effects of self-generated sad mood on regional cerebral activity: A PET study in normal subjects. Depression 1996; 4:81-88
13. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ: Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry 1997; 154:926-933
14. Bechara A, Tranel D, Damasio H, Damasio AR: Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb Cortex 1996; 6:215-225
15. Damasio AR, Tranel D, Damasio H: Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res 1990; 41:81-94
16. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
17. Spitzer RL, Williams JBW, Gibbon M: Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1987
18. McBride PA, Tierney H, DeMeo M, Chen JS, Mann JJ: Effects of age and gender on CNS serotonergic responsivity in normal adults. Biol Psychiatry 1990; 27:1143-1155
19. Mann JJ, Malone KM, Diehl DJ, Perel J, Nichols TE, Mintun MA: Positron emission tomographic imaging of serotonin activation effects on prefrontal cortex in healthy volunteers. J Cereb Blood Flow Metab 1996; 16:418-426
20. Krebs HA, Cheng LK, Wright GJ: Determination of fenfluramine and norfenfluramine in plasma using a nitrogen-sensitive detector. J Chromatogr 1984; 310:412-417
21. Myers JE, Mieczkowski T, Perel J, Abbondanza D, Cooper TB, Mann JJ: Abnormal behavioral responses to fenfluramine in patients with affective and personality disorders: Correlation with increased serotonergic responsivity. Biol Psychiatry 1994; 35:112-120
22. McNair DM, Lorr M, Droppleman LF: Manual for the Profile of Mood States. San Diego, Educational and Industrial Testing Service, 1981
23. Carmichael ST, Price JL: Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey. J Comp Neurol 1994; 346:366-402
24. Kegeles LS, Shungu DC, Anjilvel S, Chan S, Ellis SP, Xanthopoulos E, Malaspina D, Gorman JM, Mann JJ, Laruelle M, Kaufmann CA: Hippocampal pathology in schizophrenia: Magnetic resonance imaging and spectroscopy studies. Psychiatry Res Neuroimaging 2000; 98:163-175
25. Woods RP, Cherry SR, Mazziotta JC: Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr 1992; 16:620-633
26. Tyler JL, Strother SC, Zatorre RJ, Alivisatos B, Worsley KJ, Diksic M, Yamamoto YL: Stability of regional cerebral glucose metabolism in the normal brain measured by positron emission tomography. J Nucl Med 1988; 29:631-642
27. Friston KJ, Frith CD, Liddle PF, Frackowiak RS: Comparing functional (PET) images: The assessment of significant change. J Cereb Blood Flow Metab 1991; 11:690-699
28. Friston KJ: Testing for anatomically specified regional effects. Hum Brain Mapp 1997; 5:133-136
29. Andreasen NC, Rezai K, Alliger R, Swayze VW II, Flaum M, Kirchner P, Cohen G, O'Leary DS: Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia: Assessment with Xenon 133 single-photon emission computed tomography and the Tower of London. Arch Gen Psychiatry 1992; 49:943-958
30. Lahti AC, Holcomb HH, Medoff DR, Weiler MA, Tamminga CA, Carpenter WT Jr: Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task. Am J Psychiatry 2001; 158:1797-1808
31. Hampson M, Peterson BS, Skudlarski P, Gatenby JC, Gore JC: Detection of functional connectivity using temporal correlations in MR images. Hum Brain Mapp 2002; 15:247-262
32. Searle SR, Casella G, McCulloch CE: Variance Components. New York, John Wiley & Sons, 1992
33. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain: Three-Dimensional Proportional System. New York, Thieme Medical, 1988
34. Drevets WC, Ongur D, Price JL: Neuroimaging abnormalities in the subgenual prefrontal cortex: Implications for the patho-physiology of familial mood disorders. Mol Psychiatry 1998; 3:220-226
35. Ongur D, Drevets WC, Price JL: Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 1998; 95:13290-13295
36. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG: Energy on demand. Science 1999; 283:496-497
37. Shulman RG: Functional imaging studies: Linking mind and basic neuroscience. Am J Psychiatry 2001; 158:11-20
38. Mayberg HS, Brannan SK, Mahurin RK, Jerabek PA, Brickman JS, Tekell JL, Silva JA, McGinnis S, Glass TG, Martin CC, Fox PT: Cingulate function in depression: A potential predictor of treatment response. Neuroreport 1997; 8:1057-1061