Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1964-1971

  Srivastava, Ajay Kumar ^a   Dohare, Preeti ^a   Ray, Madhur ^a   Panda, Gautam ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Allylic alcohol; Cerebral ischemia; Ionone; Stroke

Indexed keywords

2 ( 2 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 2 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX1 ENYL) BUT 3 EN 2 OL; 2 ( 2,5 DIMETHYLPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 3 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 3 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 3,4 DIMETHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 ETHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 4 ETHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 4 METHOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL) BUT 3 EN 2 OL; 2 ( 4 METHYLSULFANYLPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 4 METHYLSULFANYLPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 PENTYLOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 4 PENTYLOXYPHENYL) 4(2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 PROPOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 1 ENYL)BUT 3 EN 2 OL; 2 ( 4 PROPOXYPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 TERT BUTYLPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 ( 4 TRIFLUOROMETHYLPHENYL) 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 PHENYL 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; 2 THIOPHEN 3 YL 4 ( 2,6,6 TRIMETHYLCYCLOHEX 2 ENYL)BUT 3 EN 2 OL; CURCUMIN; DIZOCILPINE; IONONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; NEUROPROTECTION; NONHUMAN; RAT; STROKE;

ANIMALS; APOPTOSIS; BRAIN EDEMA; BRAIN ISCHEMIA; CELL SURVIVAL; DRUG DESIGN; MALE; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; NORISOPRENOIDS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949492765     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.039     Document Type: Article

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