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European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1731-1738

PEG-scutellarin prodrugs: Synthesis, water solubility and protective effect on cerebral ischemia/reperfusion injury

(7) Lu, Juan a Cheng, Changmei a Zhao, Xinge b Liu, Qingfei c Yang, Ping a Wang, Yiming a Luo, Guoan a

a TSINGHUA UNIVERSITY (China)

b Jiangsu Simcere Pharmaceutical Research Institute (China)

c Tsinghua University (China)

Author keywords

Cerebral ischemia reperfusion injury; Half life; Middle cerebral artery occlusion model; PEG scutellarin prodrugs; Scutellarin

Indexed keywords

CARBOXYL GROUP; MACROGOL; NIMODIPINE; PHENOL; PRODRUG; SCUTELLAREIN; SCUTELLAREIN 4' POLYETHYLENE GLYCOL SUCCINATE ESTER DERIVATIVE; SCUTELLAREIN POLYETHYLENE GLYCOL AMIDE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISEASE MODEL; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG SYNTHESIS; HEART PROTECTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOLECULAR WEIGHT; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY; SCORING SYSTEM;

ANIMALS; APIGENIN; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GLUCURONIC ACIDS; INFARCTION, MIDDLE CEREBRAL ARTERY; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SOLUBILITY; STEREOISOMERISM; WATER;

EID: 77949492719 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2010.01.006 Document Type: Article

Times cited : (37)

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