Poly (ethylene glycol) prodrug for anthracyclines via N-Mannich base linker: Design, synthesis and biological evaluation

International Journal of Pharmaceutics

Volumn 379, Issue 1-2, 2009, Pages 90-99

  Zhao, Yong Jiang ^a,b   Wei, Wei ^a,b   Su, Zhi Guo ^a   Ma, Guang Hui ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anthracycline anticancer drug; N Mannich base; PEGylated prodrug

Indexed keywords

DAUNORUBICIN; DOXORUBICIN; MACROGOL; MANNICH BASE; PRODRUG; SALICYLAMIDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DESIGN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; MALE; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA 180; TUMOR CELL DESTRUCTION;

ANIMALS; ANTHRACYCLINES; ANTIBIOTICS, ANTINEOPLASTIC; CELL PROLIFERATION; DOXORUBICIN; DRUG CARRIERS; HUMANS; HYDROLYSIS; MALE; MANNICH BASES; MICE; MICE, INBRED ICR; POLYETHYLENE GLYCOLS; PRODRUGS; SALICYLAMIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 68649099892     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.06.013     Document Type: Article

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