Scutellarin-induced endothelium-independent relaxation in rat aorta

Phytotherapy Research

Volumn 22, Issue 11, 2008, Pages 1428-1433

  Pan, Zhenwei ^a   Feng, Tieming ^a   Shan, Luchen ^a   Cai, Benzhi ^a   Chu, Wenfeng ^a   Niu, Huili ^a   Lu, Yanjie ^a   Yang, Baofeng ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio Pharmaceutical Key Laboratory of Heilongjiang

Author keywords

Aortic artery; Calcium channel; Scutellarin; Vasorelaxation

Indexed keywords

ERIGERON BREVISCAPUS EXTRACT; SCUTELLARIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CHINESE HERB; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM; MALE; NONHUMAN; RAT; VASODILATATION; WISTAR RAT;

ANIMALS; AORTA; APIGENIN; CALCIUM; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENDOTHELIUM, VASCULAR; GLUCURONIC ACIDS; MALE; MUSCLE, SMOOTH, VASCULAR; NOREPINEPHRINE; RATS; RATS, WISTAR; VASODILATION; VASODILATOR AGENTS;

ERIGERON BREVISCAPUS; RATTUS;

EID: 57349125036     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2364     Document Type: Article

References (19)

1. Calderone V, Chericoni S, Martinelli C et al. 2004. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 370: 290-298.
2. Chen J, Liu JH, Wang T et al. 2005. The relaxation effects of six extracts from Chinese herbs on the corpus cavernosum tissue of rabbit in vitro. Zhonghua Nan Ke Xue 11: 793-795.
3. Duarte J, Perez Vizcaino F, Utrilla P et al. 1993. Vasodilatory effects of flavonoids in rat aortic smooth muscle: Structure-activity relationships. Gen Pharmacol 24: 857-862.
4. 2+ entry channels involved in contractions of rat aorta induced by endothelin-1, noradrenaline, and vasopressin. J Cardiovas Pharmacol 40: 265-276.
5. Godfraind T, Miller R, Wibo M. 1986. Calcium antagonism and calcium entry blockade. Pharmacol Rev 38: 324-416.
6. Hyman AL, Nandiwada P, Knight DS et al. 1981. Pulmonary vasodilator responses to catecholamines and sympathetic nerve stimulation in the cat. Evidence that vascular beta2 adrenoceptors are innervated. Circ Res 48: 407-415.
7. Karaki H, Ozaki H, Hori M et al. 1997. Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49: 157-230.
8. 2+ sensitization. Am J Physiol 260: C364-C370.
9. Lee MW, Severson DL. 1994. Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action. Am J Physiol 267: C659-C678.
10. Li XL, Li YQ, Yan WM et al. 2004. A study of the cardioprotective effect of breviscapine during hypoxia of cardiomyocytes. Planta Med 70: 1039-1044.
11. Liu H, Yang X, Tand R et al. 2005. Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. Pharmacol Res 51: 205-210.
12. + channel current in vascular smooth muscle cells from rat mesenteric arteries. J Membr Biol 180: 163-175.
13. Morello S, Vellecco V, Alfieri A et al. 2006. Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life Sci 78: 825-830.
14. Nelson MT, Cheng H, Rubart M et al. 1995. Relaxation of arterial smooth muscle by calcium sparks. Science 270: 633-637.
15. Nishimura J, Khalil RA, Van Breemen C. 1989. Agonist-induced vascular tone. Hypertension 13: 835-844.
16. Nishimura K, Ota M, Ito K. 1991. Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation. Br J Pharmacol 102: 215-221.
17. Satake N, Imanishi M, Keto Y et al. 2000. Genistein potentiates the relaxation induced by beta 1- and beta2-adrenoceptor activation in rat aortic rings. J Cardiovasc Pharmacol 35: 227-233.
18. Thorneloe KS, Nelson MT. 2005. Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can J Physiol Pharmacol 83: 215-242.
19. Yang XF, He W, Lu WH et al. 2003. Effects of scutellarin on liver function after brain ischemia/reperfusion in rats. Acta Pharmacol Sin 24: 1118-1124.