Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 894-899

  Pivoňková, Hana ^a   Šebest, Peter ^a   Pečinka, Petr ^a,b   Tichá, Olga ^a   Němcová, Kateřina ^a   Brázdová, Marie ^a   Jagelská, Eva Brázdová ^a   Brázda, Václav ^a   Fojta, Miroslav ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b UNIVERSITY OF OSTRAVA   (Czech Republic)

Author keywords

DNA topology; Immunoprecipitation; Intercalation; p53 DNA binding; Supercoiled DNA

Indexed keywords

ACRIDINE DERIVATIVE; CHLOROQUINE; CIRCULAR DNA; DOUBLE STRANDED DNA; DOXORUBICIN; ETHIDIUM BROMIDE; PROTEIN P53;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SUPERCOILING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ACRIDINES; BINDING, COMPETITIVE; CHLOROQUINE; DNA, SUPERHELICAL; DOXORUBICIN; HUMANS; INTERCALATING AGENTS; NUCLEIC ACID CONFORMATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77949491461     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.120     Document Type: Article

References (25)

1. Meek D.W. Tumour suppression by p53: a role for the DNA damage response?. Nat. Rev. Cancer 9 (2009) 714-723
2. Menendez D., Inga A., and Resnick M.A. The expanding universe of p53 targets. Nat. Rev. Cancer 9 (2009) 724-737
3. Brazdova M., Palecek J., Cherny D.I., et al. Role of tumor suppressor p53 domains in selective binding to supercoiled DNA. Nucleic Acids Res. 30 (2002) 4966-4974
4. Fojta M., Pivonkova H., Brazdova M., et al. Investigations of the supercoil-selective DNA binding of wild type p53 suggest a novel mechanism for controlling p53 function. Eur. J. Biochem. 271 (2004) 3865-3876
5. Gohler T., Jager S., Warnecke G., et al. Mutant p53 proteins bind DNA in a DNA structure-selective mode. Nucleic Acids Res. 33 (2005) 1087-1100
6. Jagelska E.B., Brazda V., Pecinka P., et al. DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites. Biochem. J. 412 (2008) 57-63
7. Jagelska E.B., Pivonkova H., Fojta M., et al. The potential of the cruciform structure formation as an important factor influencing p53 sequence specific binding to natural DNA targets. Biochem. Biophys. Res. Commun. 391 (2010) 1409-1414
8. Mazur S.J., Sakaguchi K., Appella E., et al. Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. J. Mol. Biol. 292 (1999) 241-249
9. McKinney K., and Prives C. Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein. Mol. Cell. Biol. 22 (2002) 6797-6808
10. Palecek E., Brazda V., Jagelska E., et al. Enhancement of p53 sequence-specific binding by DNA supercoiling. Oncogene 23 (2004) 2119-2127
11. Palecek E., Vlk D., Stankova V., et al. Tumor suppressor protein p53 binds preferentially to supercoiled DNA. Oncogene 15 (1997) 2201-2209
12. Brazdova M., Quante T., Togel L., et al. Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences. Nucleic Acids Res. 37 (2009) 1486-1500
13. Cherny D.I., Brazdova M., Palecek J., et al. Sequestering of p53 into DNA-protein filaments revealed by electron microscopy. Biophys. Chem. 114 (2005) 261-271
14. Bowater R., Aboul-Ela F., and Lilley D.M. Two-dimensional gel electrophoresis of circular DNA topoisomers. Methods Enzymol. 212 (1992) 105-120
15. Kim E., Albrechtsen N., and Deppert W. DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53. Oncogene 15 (1997) 857-869
16. Walter K., Warnecke G., Bowater R., et al. Tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes. J. Biol. Chem. 280 (2005) 42497-42507
17. R.P. Bowater, Supercoiled DNA: Structure, Encyclopedia of Life Sciences, John Wiley and Sons, Ltd., 2005, doi: 10.1038/npg.els.0003899.
18. Palecek E. Local supercoil-stabilized DNA structures. Crit. Rev. Biochem. Mol. Biol. 26 (1991) 151-226
19. Bates A.D., and Maxwell A. DNA Topology (1993), IRL Press, Oxford
20. Koga H., and Deppert W. Identification of genomic DNA sequences bound by mutant p53 protein (Gly245->Ser) in vivo. Oncogene 19 (2000) 4178-4183
21. Will K., Warnecke G., Wiesmuller L., et al. Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing. Proc. Natl. Acad. Sci. USA 95 (1998) 13681-13686
22. Pearson C.E., Zorbas H., Price G.B., et al. Inverted repeats, stem-loops, and cruciforms: significance for initiation of DNA replication. J. Cell. Biochem. 63 (1996) 1-22
23. van Holde K. Gene expression. Properly preparing promoters. Nature 367 (1994) 512-513
24. van Holde K., and Zlatanova J. Unusual DNA structures, chromatin and transcription. Bioessays 16 (1994) 59-68
25. Yakovleva T., Pramanik A., Terenius L., et al. P53 latency-out of the blind alley. Trends Biochem. Sci. 27 (2002) 612-618