Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2137-2139

  Tsou, Lun K ^a   Dutschman, Ginger E ^b   Gullen, Elizabeth A ^b   Telpoukhovskaia, Maria ^a   Cheng, Yung Chi ^b   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calixarenes; HIV HCV coinfection inhibitors; Protein surface recognition

Indexed keywords

CALIXARENE; CARBOXYLIC ACID DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TETRABUTOXY CALIX[ 4 ]ARENE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CALIXARENES; CELL LINE; CELL SURVIVAL; HEPACIVIRUS; HEPATITIS C; HIV; HIV INFECTIONS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

HEPATITIS C VIRUS;

EID: 77949484705     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.043     Document Type: Article

References (14)

1. Kim A.Y., and Chung R.T. Gastroenterology 137 (2009) 795
2. Singal A.K., and Anand B.S. World J. Gastroenterol. 15 (2009) 3713
3. Weber R., Sabin C.A., Friis-Moller N., Reiss P., El-Sadr W.M., Kirk O., Dabis F., Law M.G., Pradier C., De Wit S., Akerlund B., Calvo G., Monforte A., Rickenbach M., Ledergerber B., Phillips A.N., and Lundgren J.D. Arch. Intern. Med. 166 (2006) 1632
4. Velasco M., and Guijarro C. JAMA 283 (2000) 2526
5. Ascherl G., Hohenadl C., Schatz O., Shumay E., Bogner J., Eckhart L., Tschachler E., Monini P., Ensoli B., and Sturzl M. Blood 93 (1999) 4232
6. Chi K.D., McPhee R.A., Wagner A.S., Dietz J.J., Pantazis P., and Goustin A.S. Oncogene 15 (1997) 1051
7. Blaskovich M.A., Lin Q., Delarue F.L., Sun J., Park H.S., Coppola D., Hamilton A.D., and Sebti S.M. Nat. Biotechnol. 18 (2000) 1065
8. Sun J., Blaskovich M.A., Jain R.K., Delarue F., Paris D., Brem S., Wotoczek-Obadia M., Lin Q., Coppola D., Choi K., Mullan M., Hamilton A.D., and Sebti S.M. Cancer Res. 64 (2004) 3586
9. Sun J., Wang D.A., Jain R.K., Carie A., Paquette S., Ennis E., Blaskovich M.A., Baldini L., Coppola D., Hamilton A.D., and Sebti S.M. Oncogene 24 (2005) 4701
10. Zhou H., Wang D.A., Baldini L., Ennis E., Jain R., Carie A., Sebti S.M., and Hamilton A.D. Org. Biomol. Chem. 4 (2006) 2376
11. Perret F., Lazar A.N., and Coleman A.W. Chem. Commun. (Cambridge: England) (2006) 2425
12. Hwang, K.M.Q.; Mao, Y.; Liu, S.Y.; Choy, W.; Chen, J. Genelabs Technologies, I., USA, 1994.
13. Coveney, D. C. Benjamin (AIDS Care Pharma Limited, I.), 2005.
14. Veggel F.C.J.M.V. In: Cook H. (Ed). Calixarenes in Action (2000), Imperial College Press, London