Early-stage cervical cancer: Is surgery better than radiotherapy?

Expert Review of Anticancer Therapy

Volumn 10, Issue 3, 2010, Pages 451-460

  Undurraga, Manuela ^a   Loubeyre, Pierre ^a   Dubuisson, Jean Bernard ^a   Schneider, Dominique ^a   Petignat, Patrick ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Cervical carcinoma; Chemoradiation; Neoadjuvant chemotherapy; Quality of life; Radical hysterectomy; Radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CARBOPLATIN; CISPLATIN; FLUOROURACIL; MITOMYCIN; PACLITAXEL; VINCRISTINE;

ADJUVANT THERAPY; ANEMIA; BONE MARROW DEPRESSION; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CLINICAL TRIAL; EARLY CANCER; HUMAN; LAPAROSCOPIC SURGERY; LEUKOPENIA; PATIENT SELECTION; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PREOPERATIVE EVALUATION; QUALITY OF LIFE; RADIATION INJURY; RADICAL HYSTERECTOMY; REVIEW; SENTINEL LYMPH NODE BIOPSY; SURGICAL APPROACH; SURGICAL TECHNIQUE; THERAPY EFFECT; THROMBOCYTOPENIA; TREATMENT PLANNING; TUMOR REGRESSION; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

COMBINED MODALITY THERAPY; FEMALE; HUMANS; HYSTERECTOMY; LAPAROSCOPY; NEOPLASM STAGING; PATIENT SELECTION; QUALITY OF LIFE; SENTINEL LYMPH NODE BIOPSY; UTERINE CERVICAL NEOPLASMS;

EID: 77949451449     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/ERA.09.192     Document Type: Review

References (76)

1. World Health Organisation. Comprehensive cervical cancer control. In: A Guide to Essential Practice. WHO Geneva, Switzerland (2006
2. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 55(2), 74-108 (2005
3. Park SY, Bae DS, Nam JH et al. Quality of life and sexual problems in disease-free survivors of cervical cancer compared with the general population. Cancer 110(12), 2716-2725 (2007
4. Landoni F, Maneo A, Colombo A et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 350(9077), 535-540 (1997
5. Petsuksiri J, Chansilpa Y, Therasakvichya S et al. Treatment options in bulky stage IB cervical carcinoma. Int. J. Gynecol. Cancer 18(6), 1153-1162 (2008
6. Wertheim E. The extended abdominal operation for carcinoma uteri (based on 500 operative cases). Am. J. Obstet. Dis. Women Child 66, 169-232 (1912
7. Bartos P, Struppl D, Trhlik M et al. Da Vinci robotic surgery in gynaecological oncology: a critical interim appraisal. Ceska. Gynekol. 72(5), 354-359 (2007
8. Piver MS, Rutledge F, Smith JP. Five classes of extended hysterectomy for women with cervical cancer. Obstet. Gynecol. 44(2), 265-272 (1974
9. Havrilesky LJ, Cragun JM, Calingaert B et al. Resection of lymph node metastases influences survival in stage IIIC endometrial cancer. Gynecol. Oncol. 99(3), 689-695 (2005
10. Choi SH, Kim SH, Choi HJ, Park BK, Lee HJ. Preoperative magnetic resonance imaging staging of uterine cervical carcinoma: results of prospective study. J. Comput. Assist. Tomogr. 28(5), 620-627 (2004
11. Hancke K, Heilmann V, Straka P, Kreienberg R, Kurzeder C. Pretreatment staging of cervical cancer: is imaging better than palpation? Role of CT and MRI in preoperative staging of cervical cancer: single institution results for 255 patients. Ann. Surg. Oncol. 15(10), 2856-2861 (2008
12. Subak LL, Hricak H, Powell CB, Azizi L, Stern JL. Cervical carcinoma: computed tomography and magnetic resonance imaging for preoperative staging. Obstet. Gynecol. 86(1), 43-50 (1995
13. Wagenaar HC, Trimbos JB, Postema S et al. Tumor diameter and volume assessed by magnetic resonance imaging in the prediction of outcome for invasive cervical cancer. Gynecol. Oncol. 82(3), 474-482 (2001
14. Hricak H, Gatsonis C, Coakley FV et al. Early invasive cervical cancer: CT and MR imaging in preoperative evaluation - ACRIN/GOG comparative study of diagnostic performance and interobserver variability. Radiology 245(2), 491-498 (2007
15. Jackson KS, Naik R. Pelvic floor dysfunction and radical hysterectomy. Int. J. Gynecol. Cancer 16(1), 354-363 (2006
16. Querleu D, Leblanc E, Cartron G, Narducci F, Ferron G, Martel P. Audit of preoperative and early complications of laparoscopic lymph node dissection in 1000 gynecologic cancer patients. Am. J. Obstet. Gynecol. 195(5), 1287-1292 (2006
17. Matsuura Y, Kawagoe T, Toki N, Tanaka M, Kashimura M. Long-standing complications after treatment for cancer of the uterine cervix - clinical significance of medical examination at 5 years after treatment. Int. J. Gynecol. Cancer 16(1), 294-297 (2006
18. Wu K, Zhang WH, Zhang R, Li H, Bai P, Li XG. [Analysis of postoperative complications of radical hysterectomy for 219 cervical cancer patients]. Zhonghua Zhong Liu Za Zhi 28(4), 316-319 (2006
19. Zullo MA, Manci N, Angioli R, Muzii L, Panici PB. Vesical dysfunctions after radical hysterectomy for cervical cancer: a critical review. Crit. Rev. Oncol. Hematol. 48(3), 287-293 (2003
20. Hauspy J, Beiner M, Harley I, Ehrlich L, Rasty G, Covens A. Sentinel lymph nodes in early stage cervical cancer. Gynecol. Oncol. 105(2), 285-290 (2007
21. Li G, Yan X, Shang H, Wang G, Chen L, Han Y. A comparison of laparoscopic radical hysterectomy and pelvic lymphadenectomy and laparotomy in the treatment of Ib-IIa cervical cancer. Gynecol. Oncol. 105(1), 176-180 (2007
22. Lowe MP, Chamberlain DH, Kamelle SA, Johnson PR, Tillmanns TD. A multi-institutional experience with robotic-assisted radical hysterectomy for early stage cervical cancer. Gynecol. Oncol. 113(2), 191-194 (2009
23. Nam JH, Kim JH, Kim DY et al. Comparative study of laparoscopico-vaginal radical hysterectomy and abdominal radical hysterectomy in patients with early cervical cancer. Gynecol. Oncol. 92(1), 277-283 (2004
24. Di Stefano AB, Acquaviva G, Garozzo G et al. Lymph node mapping and sentinel node detection in patients with cervical carcinoma: a 2-year experience. Gynecol. Oncol. 99(3), 671-679 (2005
25. Altgassen C, Hertel H, Brandstadt A, Kohler C, Durst M, Schneider A. Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO study group. J. Clin. Oncol. 26(18), 2943-2951 (2008
26. Leblanc E, Narducci F, Frumovitz M et al. Therapeutic value of pretherapeutic extraperitoneal laparoscopic staging of locally advanced cervical carcinoma. Gynecol. Oncol. 105(2), 304-311 (2007
27. Marnitz S, Kohler C, Roth C, Fuller J, Hinkelbein W, Schneider A. Is there a benefit of pretreatment laparoscopic transperitoneal surgical staging in patients with advanced cervical cancer? Gynecol. Oncol. 99(3), 536-544 (2005
28. Vergote I, Tsolakidis D, Mortier D et al. Value of positron emission tomography of the para-aortic lymph nodes in cervical carcinoma stage IB2-IIIB. J. Clin. Oncol. 26(34), 5654-5655 (2008
29. Boughanim M, Leboulleux S, Rey A et al. Histologic results of para-aortic lymphadenectomy in patients treated for stage IB2/II cervical cancer with negative [18F] fluorodeoxyglucose positron emission tomography scans in the para-aortic area. J. Clin. Oncol. 26(15), 2558-2561 (2008
30. Kim PY, Monk BJ, Chabra S et al. Cervical cancer with paraaortic metastases: significance of residual paraaortic disease after surgical staging. Gynecol. Oncol. 69(3), 243-247 (1998
31. Yabuki Y, Asamoto A, Hoshiba T, Nishimoto H, Kitamura S. Dissection of the cardinal ligament in radical hysterectomy for cervical cancer with emphasis on the lateral ligament. Am. J. Obstet. Gynecol. 164(1 Pt 1), 7-14 (1991
32. Raspagliesi F, Ditto A, Hanozet F et al. Nerve-sparing radical hysterectomy in cervical cancer: evolution of concepts. Gynecol. Oncol. 107(1 Suppl. 1), S119-S121 (2007
33. Höckel M, Konerding MA, Peter Heuel C. Liposuction-assisted nerve-sparing extended radical hysterectomy: oncologic rationale, surgical anatomy, and feasibility study. Am. J. Obstet. Gynecol. 178(5), 971-976 (1998
34. Rob L, Pluta M, Strnad P et al. A less radical treatment option to the fertility-sparing radical trachelectomy in patients with stage I cervical cancer. Gynecol. Oncol. 111(2 Suppl.), S116-S120 (2008
35. Hoffman MS. Extent of radical hysterectomy: evolving emphasis. Gynecol. Oncol. 94(1), 1-9 (2004
36. Stegeman M, Louwen M, van der Velden J et al. The incidence of parametrial tumor involvement in select patients with early cervix cancer is too low to justify parametrectomy. Gynecol. Oncol. 105(2), 475-480 (2007
37. Lee SJ, Schover LR, Partridge AH et al. American society of clinical oncology recommendations on fertility preservation in cancer patients. J. Clin. Oncol. 24(18), 2917-2931 (2006
38. Milliken DA, Shepherd JH. Fertility preserving surgery for carcinoma of the cervix. Curr. Opin. Oncol. 20(5), 575-580 (2008
39. Diaz JP, Sonoda Y, Leitao MM et al. Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma. Gynecol. Oncol. 111(2), 255-260 (2008
40. Beiner ME, Hauspy J, Rosen B et al. Radical vaginal trachelectomy vs. radical hysterectomy for small early stage cervical cancer: a matched case-control study. Gynecol. Oncol. 110(2), 168-171 (2008
41. Leitao MM Jr, Chi DS. Fertility-sparing options for patients with gynecologic malignancies. Oncologist 10(8), 613-622 (2005
42. Chuang LT, Lerner DL, Liu CS, Nezhat FR. Fertility-sparing robotic-assisted radical trachelectomy and bilateral pelvic lymphadenectomy in early-stage cervical cancer. J. Minim. Invasive. Gynecol. 15(6), 767-770 (2008
43. Farthing A. Conserving fertility in the management of gynaecological cancers. Br. J. Obstet. Gynaecol. 113(2), 129-134 (2006
44. Chen Y, Xu H, Zhang Q, Li Y, Wang D, Liang Z. A fertility-preserving option in early cervical carcinoma: laparoscopy-assisted vaginal radical trachelectomy and pelvic lymphadenectomy. Eur. J. Obstet. Gynecol. Reprod. Biol. 136(1), 90-93 (2008
45. Shepherd JH, Mould T, Oram DH. Radical trachelectomy in early stage carcinoma of the cervix: outcome as judged by recurrence and fertility rates. Br. J. Obstet. Gynaecol. 108(8), 882-885 (2001
46. Ungar L, Palfalvi L, Hogg R et al. Abdominal radical trachelectomy: a fertility-preserving option for women with early cervical cancer. Br. J. Obstet. Gynaecol. 112(3), 366-369 (2005
47. Plante M, Renaud MC, Hoskins IA, Roy M. Vaginal radical trachelectomy: a valuable fertility-preserving option in the management of early-stage cervical cancer. A series of 50 pregnancies and review of the literature. Gynecol. Oncol. 98(1), 3-10 (2005
48. Bernardini M, Barrett J, Seaward G, Covens A. Pregnancy outcomes in patients after radical trachelectomy. Am. J. Obstet. Gynecol. 189(5), 1378-1382 (2003
49. Patel FD, Sharma SC, Negi PS, Ghoshal S, Gupta BD. Low dose rate vs. high dose rate brachytherapy in the treatment of carcinoma of the uterine cervix: a clinical trial. Int. J. Radiat. Oncol. Biol. Phys. 28(2), 335-341 (1994
50. Hareyama M, Sakata K, Oouchi A et al. High-dose-rate versus low-dose-rate intracavitary therapy for carcinoma of the uterine cervix: a randomized trial. Cancer 94(1), 117-124 (2002
51. Lertsanguansinchai P, Lertbutsayanukul C, Shotelersuk K et al. Phase III randomized trial comparing LDR and HDR brachytherapy in treatment of cervical carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 59(5), 1424-1431 (2004
52. Kleinerman RA, Boice JD Jr, Storm HH et al. Second primary cancer after treatment for cervical cancer. An International Cancer Registries study. Cancer 76(3), 442-452 (1995
53. Ploch E. Hormonal replacement therapy in patients after cervical cancer treatment. Gynecol. Oncol. 26(2), 169-177 (1987
54. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecology Oncology Group study. Gynecol. Oncol. 38(3), 352-357 (1990
55. Sedlis A, Bundy BN, Rotman MZ, Lentz SS, Muderspach LI, Zaino RJ. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecology Oncology Group study. Gynecol. Oncol. 73(2), 177-183 (1999
56. Rotman M, Sedlis A, Piedmonte MR et al. A Phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features: follow-up of a Gynecologic Oncology Group study. Int. J. Radiat. Oncol. Biol. Phys. 65(1), 169-176 (2006
57. Peters WA 3rd, Liu PY, Barrett RJ 2nd et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J. Clin. Oncol. 18(8), 1606-1613 (2000
58. Kjorstad KE, Martimbeau PW, Iversen T. Stage IB carcinoma of the cervix, the Norwegian Radium Hospital: results and complications. III. Urinary and gastrointestinal complications. Gynecol. Oncol. 15(1), 42-47 (1983
59. Greimel ER, Winter R, Kapp KS, Haas J. Quality of life and sexual functioning after cervical cancer treatment: a long-term follow-up study. Psychooncology 18(5), 476-482 (2009
60. Tierney JF, Vale C, Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer. Clin. Oncol. (R. Coll. Radiol.) 20(6), 401-416 (2008
61. Eddy GL, Bundy BN, Creasman WT et al. Treatment of ('bulky') stage IB cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical hysterectomy and pelvic/para-aortic lymphadenectomy: a Phase III trial of the Gynecologic Oncology Group. Gynecol. Oncol. 106(2), 362-369 (2007
62. Napolitano U, Imperato F, Mossa B, Framarino ML, Marziani R, Marzetti L. The role of neoadjuvant chemotherapy for squamous cell cervical cancer (Ib-IIIb), a long-term randomized trial. Eur. J. Gynaecol. Oncol. 24(1), 51-59 (2003
63. Sardi JE, Giaroli A, Sananes C et al. Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: the final results. Gynecol. Oncol. 67(1), 61-69 (1997
64. Cai HB, Chen HZ, Yin HH. Randomized study of preoperative chemotherapy versus primary surgery for stage IB cervical cancer. J. Obstet. Gynaecol. Res. 32(3), 315-323 (2006
65. Benedetti-Panici P, Greggi S, Colombo A et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J. Clin. Oncol. 20(1), 179-188 (2002
66. Tierney JF, Stewart LA, Parmar MK. Can the published data tell us about the effectiveness of neoadjuvant chemotherapy for locally advanced cancer of the uterine cervix? Eur. J. Cancer 35(3), 406-409 (1999
67. Hsu WC, Chung NN, Chen YC et al. Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer. Eur. J. Cancer 35(3), 406-409 (1999
68. Quality of life and sexual functioning in cervical cancer survivors. J. Clin. Oncol. 23(30), 7428-7436 (2005
69. Sundar S, Horne A, Kehoe S. Cervical cancer. Clin. Evid. (13), 2285-2292 (2005
70. Waggoner SE. Cervical cancer. Lancet 361(9376), 2217-2225 (2003
71. Schover LR, Fife M, Gershenson DM. Sexual dysfunction and treatment for early stage cervical cancer. Cancer 63(1), 204-212 (1989
72. Yessaian A, Magistris A, Burger RA, Monk BJ. Radical hysterectomy followed by tailored postoperative therapy in the treatment of stage IB2 cervical cancer: feasibility and indications for adjuvant therapy. Gynecol. Oncol. 94(1), 61-66 (2004
73. Keys HM, Bundy BN, Stehman FB et al. Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecology Oncology Group. Gynecol. Oncol. 89(3), 343-353 (2003
74. Duenas-Gonzalez A, Lopez-Graniel C, Gonzalez-Enciso A et al. A Phase II study of multimodality treatment for locally advanced cervical cancer: neoadjuvant carboplatin and paclitaxel followed by radical hysterectomy and adjuvant cisplatin chemoradiation. Ann. Oncol. 14(8), 1278-1284 (2003
75. Minagawa Y, Kigawa J, Irie T, Okada M, Kanamori Y, Terakawa N. Radical surgery following neoadjuvant chemotherapy for patients with stage IIIB cervical cancer. Ann. Surg. Oncol. 5(6), 539-543 (1998
76. Takeshima N, Umayahara K, Fujiwara K, Hirai Y, Takizawa K, Hasumi K. Treatment results of adjuvant chemotherapy after radical hysterectomy for intermediate- and high-risk stage IB-IIA cervical cancer. Gynecol. Oncol. 103(2), 618-622 (2006