Antioxidant and antihyperlipidemic effect of Solanum nigrum fruit extract on the experimental model against chronic ethanol toxicity

Pharmacognosy Magazine

Volumn 6, Issue 21, 2010, Pages 42-50

  Arulmozhi, Vadivel ^a   Krishnaveni, Mani ^a   Karthishwaran, Kandhan ^a   Dhamodharan, Ganesan ^a   Mirunalini, Sankaran ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antihyperlipidemic; Antioxidant; Ethanol; Solanum nigrum

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; ASCORBIC ACID; CHOLESTEROL; FATTY ACID; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; SOLANUM NIGRUM EXTRACT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERLIPIDEMIC EFFECT; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MODEL; FATTY ACID BLOOD LEVEL; FRUIT; HISTOPATHOLOGY; LIVER WEIGHT; MALE; NONHUMAN; RAT; SOLANUM NIGRUM; TISSUE LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 77949448003     PISSN: 09731296     EISSN: None     Source Type: Journal    
DOI: 10.4103/0973-1296.59965     Document Type: Article

References (57)

1. National institute on Alcohol abuse and alcoholism. Alcohol alert No.19: Alcohol and the liver. PH 329. Rockville, MD: The Institute; 1993.
2. Shaw S, Jayatilleke E, Ross WA, Gordon ER, Leiber CS. Ethanol induced lipid peroxidation; Potentiation by long term alcohol feeding and attenuation by methionine. J Lab Clin Med 1981;98:417-424
3. Jewell SA, Di Monte D, Gentile A, Guglielmi A, Altomare E, Albano E. Decreased hepatic glutathione in chronic alcoholic patients. J Hepatol 1986;3:1-6.
4. Sadrzadeh SM, Nanji AA, Meydani M. Effect of chronic ethanol feeding on plasma in normal and vitamin E defi cient rats: Relationship to lipid peroxidation. Biochem Pharmacol 1994;47:2005-2010
5. Balasubramaiyan V, Manju V, Nalini N. Effect of leptin administration on plasma and tissue lipids in alcohol induced liver injury. Hum Exp Toxicol 2003;22:149-154
6. Sun AY, Ingelman-Sundberg M, Neve E, Matsumoto H, Nishitani Y, Minowa Y, et al. Ethanol and oxidative stress. Alc Clin Exp Res. 2001;25:237S-43S.
7. Zhou Z, Sun X, Kang JY. Methionine protection against alcohol liver injury through inhibition of oxidative stress. Exp Biol Med 2003;222:214-222
8. Ong HC. Sayuran Khasiat Makanan Dan Ubatan, Utusan Publication Distributors. 2nd Bhd. Fakulti Sains: Universiti Malaya; 2003. p. 92-93
9. Latiff KM. Tumbuhan Ubatan Malayasia, Universiti Kebangsaan Malaysia in collaboration with ministry of science, Technology and Innovation; 2002. p. 589.
10. Dhellot JR, Matouba E, Maloumbi MG, Nzikou JM. Extraction and nutritional properties of Solanum nigrum L seed oil. Afr J Biotech 2006;5:987-991
11. An L, Tang JT, Liu XM. Review about mechanisms of anticancer of Solanum nigrum [Article in Chinese]. Zhongguo Zhong Yao Za Zhi 2006;31:1225-1226
12. Tariq Al-Qirim, Syed MZ, Moyad S, Ghassan S, Naheed B. Effect of Solanum nigrum on immobilization stress induced antioxidant defense changes in rat. Res J Biol Sci 2008;3:1426-1429
13. Perez RM, Perez JA, Garcia LM, Sossa M. Neuropharmacological activity of Solanum nigrum fruit. J Ethnopharmacol 1998;62:43-48
14. Kumar VP, Shashidra S, Kumar MM, Sridhara BY. Cytoprotective role of Solanum nigrum against gentamycin induced kidney cell (Vero cells) damage in vitro. Fitoterapia 2001;72:481-486
15. Jainu M, Shyamala Devi CS. Antioxidant effect of Methanolic extract of Solanum nigrum berries on aspirin induced gastric mucosal injury. Indian J Clin Biochem 2004;19:57-61.
16. Rani P, Khullar N. Antimicrobial evaluation of some medicinal plants for their anticentric potential against multidrug resistant. Phytother Res 2004;18:670-673
17. Zakaria ZA, Gopalan HM, Zainal H, Mohd NH, Morsid NA, Aris A, et al. Antinociceptive, antiinfl ammatory and Antipyretic effects of Solanum nigrum Chloroform extract in animal models. Pharma Soci Jpn 2006;126:1171-1178
18. Raju K, Anbuganapathy G, Gokulakrishnan V, Rajkapoor B, Jayakar B, Manian S. Effect of dried fruits of Solanum nigrum Linn against CCL4-induced hepatic damage in rats. Biol Pharm Bul 2003;26:1618-1619
19. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Cho FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4 induced oxidative damage in rats. Chemico Biol Interact 2008;171:283-293
20. Hsieh CC, Fang HL, Lina WC. Inhibitory effect of Solanum nigrum on thioacetamide induced liver fi brosis in mice. J Ethnopharmacol 2008;119:117-121
21. Sandhir R, Gill KD. Hepatoprotective effects of Liv-52 on ethanol induced liver damage in rats. Indian J Exp Biol 1999;37:762-766
22. Potawel SE, Sinha SD, Shroff KK, Dhalawat HJ, Boraste SS, Gandhi SP, et al. Solanum nigrum Linn: A phytochemical Review. Pharmacology 2008;3:140-163
23. Ikeda T, Tsumagari H, Nohara T. Steroidal oligoglycosides from Solanum nigrum growing in Azerbaijan. Biologicheskikh Nauk 1978;3:15-18
24. Hossain MZ, Shibib BH, Rahman R. Hypoglycemic effects of coccina indica inhibition of key glycogenic enzyme, glucose-6- phosphatase. Indian J Exp Biol 1992;30:418-420
25. Rajakrishnan V, Vishvanathan P, Menon VP. Hepatotoxic effect of alcohol on female rats and sibilings: Effect of n-acetyl cysteine. Hepatol Res 1997;9:37-50.
26. Niehaus WG, Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968;6:126-130
27. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959;82:70-77
28. Roe JH, Kuether CA. The determination of ascorbic acid in whole blood and urine through the 2, 4-dinitrophenlyhydrazine derivative of dehydroascorbic acid. J Biol Chem 1943;11:145-164
29. Baker H, Frank O, De Angelis B, Feingold S. Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nut Res 1980;21:531-536
30. Folch J, Lees M, Sloane Stanly GH. A simple method for the isolation and purifi cation of total lipids from animal tissues. J Biol Chem 1957;226:497-509
31. Friedwald WT, Levy RJ, Fredricken DS. Estimation of VLDL-cholesterol in the plasma without the use of preparative ultracentrifuge. Clin Chem 1972;18:449.
32. Leiber CS. Alcohol and the liver: Metabolism of alcohol and its role in hepatic and extrahepatic disease. Mount Sinai J Med 2000;64:84-94.
33. Rubin E. The chemical pathogenesis of alcohol induced tissue injury. Alc Heal Res World 1993;17:272-278
34. Nanji AA, Zhao S, Hossein Sadrzadeh SM, Dannenberg AJ, Tahan SR, Waxman DJ. Markedly enhanced cytochrome p450 2E1 induction and lipid peroxidation is associated with severe liver injury in fi sh oil ethanol fed rats. Alcoholism. Clin Exp Res 1994;18:1280-1285
35. Fernandez V, Videla IA. Effect of acute and chronic ethanol ingestion on the content of reduced glutathione on various tissues of the rat. Experientia 1981;37:392-394
36. Jaya DS, Augestine J, Menon VP. Role of lipid peroxides, glutathione and antiperoxidative enzymes in alcohol and drug toxicity. Indian J Exp Biol 1993;31:453-459
37. Frenandez-Checa JC, Kaplowitz N, Garcia Ruiz C, Colell A, Miranda M. GSH transport in mitochondria: Defense against TNF-induced oxidative stress and alcohol induced defect. Am J Physiol 1997;273:7-17.
38. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;74:139-162
39. Hemila H, Roberts P, Wikstrom M. Activated polymorphonuclear leucocytes consume vitamin C. FEBS Lett 1985;178:25-30
40. Nishikimi M. Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system. Biochem Biophys Res Commun 1975;63:463-468
41. Bielski BH. Chemistry of Ascorbic acid radicals: Ascorbic acid: Chemistry, metabolism and uses. Adv Chem Ser 1982;200:81-100.
42. Bodannes RS, Chan PC. Ascorbic acid as a scavenger of singlet oxygen. FEBS Lett 1979;105:195-196
43. Packer L. Vitamin C and redox cyclic antioxidants in vitamin C in health and disease. In: Packer L, Fuchs J, editors. New York: Marcel Dekker Inc; 1997. p. 95.
44. Ray G, Hussain SA. Oxidants, antioxidants and carcinogenesis. Indian J Exp Biol 2002;40:1213-1232
45. Machlin LJ. Vitamin E: A comprehensive treatise. New York: Dekker; 1980.
46. Suresh MV, Lal JJ, Kumar SC, Indra M. Interaction of ethanol and ascorbic acid on lipid metabolism in guinea pigs. Indian J Exp Biol 1997;35:1065-1069
47. Bjorneboe GA, Johnsen J, Bjorneboe A, Morland J. Effect of heavy alcohol consumption on serum concentration of fat soluble vitamins and selenium. Alc Alcoholism 1987;1:533-537
48. Sarwat S, Parvez M, Iqbal M, Athar M. Crude extract of hepatoprotective plants, Solanum nigrum and Chicorium intybus inhibit free radical mediated DNA damage. J Ethanopharmacol 1995;45:189-192
49. Lee SJ, Ko JH, Lim K, Lim KT. 150 kDa glycoprotein isolated from Solanum nigrum Linn enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse. Pharm Res 2005;51:399-408.
50. Avogaro P, Caffolatu G. Changes in the composition and physiochemical characteristic of serum lipoprotein during ethanol induced lipidaemia in alcoholic subjects. McTab Clin Exp 1975;219:1231-1242
51. Baraona E, Leiber CS. Effects of ethanol on lipid metabolism. J Lipid Res 1979;20:289-315.
52. Baraona E, Sanolainen M, Karrenty C, Leo Mariaya A, Leiber CS. Pathogenesis of alcoholic hypertriglyceridemia. Trans Asses Am Physic 1983;96:309-315
53. Ashakumari L, Vijyammal PL. Additive effect alcohol and nicotine on lipid metabolism in rats. Indian J Exp Biol 1993;31:270-274
54. Cunname SC. Hepatic triacylglycerol accumulation induced by ethanol and CCL4: Interactions with essential fatty acids and prostaglandins. Alc Clin Exp Res 1987;11:25-31
55. Kaffarnik H, Schneider J, Schuboty R, Hausmann L, Multifeilner G, Muhlfelne O, et al. Plasma lipids triglyceride/FFA pattern and plasma insulin in fasted healthy volunteers during continuous ingestion of ethanol: Infl uence of lipids inhibited by nicotinic acid. Atherosclerosis 1978;29:1-7.
56. Frayn KN. Insulin resistance and lipids metabolism. Curr Opin Lipidol 1993;4:197-204.
57. Zhihong Z, Anuam J, Bar K, Basalingappa LH. Effects of ethanol on the incorporation of FFA in cerebral membrane phospholipids. Neuro Chem Int 1996;28:552-555