Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle

Oncology Reports

Volumn 23, Issue 4, 2010, Pages 1153-1158

  Han, Yong Hwan ^a   Moon, Hwa Jin ^a   You, Bo Ra ^a   Kim, Sung Zoo ^a   Kim, Suhn Hee ^a   Park, Woo Hyun ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Apoptosis; Caspase; Cell cycle; HeLa; Propyl gallate

Indexed keywords

CASPASE 3; CASPASE 8; GALLIC ACID PROPYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; DNA DETERMINATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL PROLIFERATION; CELL SEPARATION; FLOW CYTOMETRY; G1 PHASE; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROPYL GALLATE;

EID: 77949425688     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000745     Document Type: Article

References (31)

1. Daniel JW: Metabolic aspects of antioxidants and preservatives. Xenobiotica 16: 1073-1078, 1986.
2. Dacre JC: Long-term toxicity study of n-propyl gallate in mice. Food Cosmet Toxicol 12: 125-129, 1974.
3. Wu TW, Fung KP, Zeng LH, Wu J and Nakamura H: Propyl gallate as a hepatoprotector in vitro and in vivo. Biochem Pharmacol 48: 419-422, 1994.
4. Rosin MP and Stich HF: Enhancing and inhibiting effects of propyl gallate on carcinogen-induced mutagenesis. J Environ Pathol Toxicol 4: 159-167, 1980.
5. Abdo KM, Huff JE, Haseman JK and Alden CJ: No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice. Food Chem Toxicol 24: 1091-1097, 1986.
6. Reddan JR, Giblin FJ, Sevilla M, Padgaonkar V, Dziedzic DC, Leverenz VR, Misra IC, Chang JS and Pena JT: Propyl gallate is a superoxide dismutase mimic and protects cultured lens epithelial cells from H2O2 insult. Exp Eye Res 76: 49-59, 2003.
7. Chen CH, Liu TZ, Chen CH, Wong CH, Chen CH, Lu FJ and Chen SC: The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells. Mol Nutr Food Res 51: 962-968, 2007.
8. Hirose M, Yada H, Hakoi K, Takahashi S and Ito N: Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multiorgan carcinogenesis model. Carcinogenesis 14: 2359-2364, 1993.
9. Kobayashi H, Oikawa S, Hirakawa K and Kawanishi S: Metal-mediated oxidative damage to cellular and isolated DNA by gallic acid, a metabolite of antioxidant propyl gallate. Mutat Res 558: 111-120, 2004.
10. Kawanishi S, Oikawa S and Murata M: Evaluation for safety of antioxidant chemopreventive agents. Antioxid Redox Signal 7: 1728-1739, 2005.
11. Han YH and Park WH: Propyl gallate inhibits the growth of HeLa cells via regulating intracellular GSH level. Food and chemical toxicology. Br Indust Biol Res Assoc 47: 2531-2538, 2009.
12. Nakagawa Y, Nakajima K, Tayama S and Moldeus P: Metabolism and cytotoxicity of propyl gallate in isolated rat hepatocytes: effects of a thiol reductant and an esterase inhibitor. Mol Pharmacol 47: 1021-1027, 1995.
13. Boyd I and Beveridge EG: Relationship between the antibacterial activity towards Escherichia coli NCTC 5933 and the physicochemical properties of some esters of 3,4,5-trihydroxybenzoic acid (Gallic acid). Microbios 24: 173-184, 1979.
14. Miller C, Castonguay A and Teel RW: Modulation of the mutagenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) by phenolic compounds. Mutat Res 368: 221-233, 1996.
15. Jacobi H, Eicke B and Witte I: DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II). Free Radic Biol Med 24: 972-978, 1998.
16. Shi Y: Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9: 459-470, 2002.
17. Ashkenazi A and Dixit VM: Death receptors: signaling and modulation. Science 281: 1305-1308, 1998.
18. Budihardjo I, Oliver H, Lutter M, Luo X and Wang X: Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Dev Biol 15: 269-290, 1999.
19. Mehmet H: Caspases find a new place to hide. Nature 403: 29-30, 2000.
20. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
21. Liu X, Yue P, Zhou Z, Khuri FR and Sun SY: Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Nat Cancer Inst 96: 1769-1780, 2004.
22. Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, Kim BK and Lee YY: Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res 60: 3065-3071, 2000.
23. Han YH, Kim SZ, Kim SH and Park WH: Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH. Cancer Lett 270: 40-55, 2009.
24. Han YH, Kim SZ, Kim SH and Park WH: Apoptosis in pyrogallol-treated Calu-6 cells is correlated with the changes of intracellular GSH levels rather than ROS levels. Lung Cancer 59: 301-314, 2008.
25. Han YH, Kim SZ, Kim SH and Park WH: Arsenic trioxide inhibits growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am J Physiol Renal Physiol 293: F511-F520, 2007.
26. Han YH, Kim SW, Kim SH, Kim SZ and Park WH: 2,4-Dinitrophenol induces G1 phase arrest and apoptosis in human pulmonary adenocarcinoma Calu-6 cells. Toxicol In Vitro 22: 659-670, 2008.
27. Kim SW, Han YW, Lee ST, Jeong HJ, Kim SH, Kim IH, Lee SO, Kim DG, Kim SZ and Park WH: A superoxide anion generator, pyrogallol, inhibits the growth of HeLa cells via cell cycle arrest and apoptosis. Mol Carcinog 47: 114-125, 2008.
28. Porter AG and Janicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6: 99-104, 1999.
29. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC: Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371: 346-347, 1994.
30. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132, 1997.
31. Cohen GM: Caspases: the executioners of apoptosis. Biochem J 326 (Pt 1): 1-16, 1997.