The IGF-1/IGF-1R signaling axis in the skin: A new role for the dermis in aging-associated skin cancer

Oncogene

Volumn 29, Issue 10, 2010, Pages 1475-1485

  Lewis, D A ^a   Travers, J B ^a,b   Somani, A K ^a   Spandau, D F ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Aging; Fibroblasts; IGF 1R; Keratinocytes; Skin cancer; UVB

Indexed keywords

DNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ADULT; AGED; AGING; ARTICLE; CELL AGING; CONTROLLED STUDY; DERMIS; DNA DAMAGE; GENE EXPRESSION; GENE SILENCING; GERIATRICS; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; SKIN FIBROBLAST; ULTRAVIOLET B RADIATION;

ADULT; AGE FACTORS; AGED; APOPTOSIS; CELLS, CULTURED; DERMIS; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; KERATINOCYTES; MALE; RECEPTOR, IGF TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; ULTRAVIOLET RAYS; YOUNG ADULT;

EID: 77949424290     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.440     Document Type: Article

References (20)

1. Chuang T-Y, Lewis DA, Spandau DF. (2005). Decreased incidence of nonmelanoma skin cancer in patients with type 2 diabetes mellitus using insulin: a pilot study. Br J Dermatol 153: 552-557.
2. Cotton J, Spandau DF. (1997). Ultraviolet B dose influences the induction of apoptosis and p53 in human keratinocytes. Radiat Res 147: 148-155.
3. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367.
4. Donovan EA, Kummar S. (2008). Role of the insulin-like growth factor-1R system in colorectal carcinogenesis. Crit Rev Oncol-Hematol 66: 91-98.
5. Dziadziuszko R, Camidge DR, Hirsch FR. (2008). The insulin-like growth factor in lung cancer. J Thoracic Oncol 3: 815-818.
6. Ferber A, Chang C, Sells C, Ptasznik A, Cristofalo V et al. (1993). Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene. J Biol Chem 268: 17883-17888.
7. Kraemer KH. (1997). Sunlight and skin cancer: another link revealed. Proc Natl Acad Sci USA 94: 11-14.
8. Krtolica A, Parrinello S, Lockett S, Desprez P-Y, Campisi J. (2001). Senescent fibroblasts promote epithelial cell growth and tumorigen-esis: a link between cancer and aging. Proc Natl Acad Sci USA 98: 12072-12077.
9. Kuhn C, Kumar M, Hurwitz SA, Cotton J, Spandau DF. (1999). Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation. Intl J Cancer 80: 431-438.
10. Lann D, LeRoith D. (2008). The role of endocrine insulin-like growth factor-1 and insulin in breast cancer. J Mammary Gland Biol Neoplasia 13: 371-379.
11. Lewis DA, Hurwitz SA, Spandau DF. (2003a). UVB-induced apoptosis in normal human keratinocytes: role of the erbB receptor family. Exp Cell Res 284: 316-327.
12. Lewis DA, Zweig B, Hurwitz SA, Spandau DF. (2003b). Inhibition of erbB receptor family members protects HaCaT kerati-nocytes from UVB-induced apoptosis. J Invest Dermatol 120: 483-488.
13. Lewis DA, Spandau DF. (2007). UVB-induced activation of NF-kB is regulated by the IGF-1R and dependent on p38 MAPK. J Invest Dermatol 128: 1022-1029.
14. Lewis DA, Travers JB, Spandau DF. (2008a). A new paradigm for the role of aging in the development of skin cancer. J Invest Dermatol 129: 787-791.
15. Lewis DA, Yi Q, Travers JB, Spandau DF. (2008b). UVB-induced senescence in human keratinocytes requires a functional IGF-1R and p53. Mol Biol Cell 19: 1346-1353.
16. Parrinello S, Coppe J-P, Krtolica A, Campisi J. (2005). Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Science 118: 485-496.
17. Pollak M. (2008). Insulin insulin-like growth factor signaling in neoplasia. Nature Rev Cancer 8: 915-928.
18. Shelton DN, Chang E, Whittier PS, Choi D, Funk WD. (1999). Microarray analysis of replicative senescence. Curr Biol 9: 939-945.
19. Tavakkol A, Elder JT, Griffiths CEM, Cooper KD, Talwar H, Fisher GJ et al. (1992). Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J Invest Dermatol 99: 343-349.
20. Whiteman DC, Whiteman CA, Green AC. (2001). Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. Cancer Causes Control 12: 69-82.