Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes

Cardiovascular Research

Volumn 86, Issue 1, 2010, Pages 55-62

  Raucci Jr , Frank J ^a   Wijesinghe, Dayanjan S ^b   Chalfant, Charles E ^b,c,d   Baumgarten, Clive M ^a,e  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^e Virginia Commonwealth University   (United States)

Author keywords

Ceramide; Cl channel; ICl,swell; Sphingomyelinase; VRAC

Indexed keywords

ANION; CERAMIDE; CHLORIDE; EBSELEN; LIPID; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN PHOSPHODIESTERASE; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARDIOVASCULAR DISEASE; CHLORIDE CURRENT; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE; ISOLATED HEART; NONHUMAN; OSMOSIS; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; TANDEM MASS SPECTROMETRY; WHOLE CELL;

ANIMALS; ANTIOXIDANTS; AZOLES; CELLS, CULTURED; CHLORIDE CHANNELS; CHLORIDES; CYCLOPENTANES; ESTROGEN ANTAGONISTS; HEART VENTRICLES; INDANS; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; ORGANOSELENIUM COMPOUNDS; OSMOTIC PRESSURE; PATCH-CLAMP TECHNIQUES; RABBITS; REACTIVE OXYGEN SPECIES; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; TAMOXIFEN;

EID: 77949374808     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp399     Document Type: Article

References (46)

1. Baumgarten CM, Browe DM, Ren Z. Swelling- and stretch-activated chloride channels in the heart: regulation and function. In: Kamkin A, Kiseleva I, eds, Mechano-Electric Feedback in the Heart: Fundamental and Clinical Aspects. Moscow: Academic Book; 2005. p79-102.
2. Duan DY, Liu LL, Bozeat N, Huang ZM, Xiang SY, Wang GL et al. Functional role of anion channels in cardiac diseases. Acta Pharmacol Sin 2005;26:265-278.
3. Hume JR, Duan D, Collier ML, Yamazaki J, Horowitz B. Anion transport in heart. Physiol Rev 2000;80:31-81.
4. - current elicited by β1 integrin stretch in rabbit ventricular myocytes. J Gen Physiol 2004;124:273-287.
5. Browe DM, Baumgarten CM. EGFR kinase regulates volume-sensitive chloride current elicited by integrin stretch via PI-3K and NADPH oxidase in ventricular myocytes. J Gen Physiol 2006;127:237-251.
6. - current by angiotensin II signalling and NADPH oxidase in rabbit ventricle. Cardiovasc Res 2008;77:73-80.
7. 2 signals chloride channel activation in cell volume regulation and cell proliferation. J Biol Chem 2004;279:13301-13304.
8. - channel. Proc Natl Acad Sci USA 2004;101:6770-6773.
9. 2+/calmodulin-dependent protein kinase II. J Biol Chem 2005;280:3548-3554.
10. ATP channels. (Abstract). Biophys J 2005;88:289a.
11. Du XL, Gao Z, Lau CP, Chiu SW, Tse HF, Baumgarten CM et al. Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases. J Gen Physiol 2004;123:427-439.
12. Walsh KB, Zhang J. Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase. Am J Physiol Heart Circ Physiol 2005;289: H2566-H2574.
13. Browe DM, Baumgarten CM. Stretch of β1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes. J Gen Physiol 2003;122:689-702.
14. Sorota S. Tyrosine protein kinase inhibitors prevent activation of cardiac swelling-induced chloride current. Pflugers Arch 1995;431:178-185.
15. Duan D, Cowley S, Horowitz B, Hume JR. A serine residue in ClC-3 links phosphorylation-dephosphorylation to chloride channel regulation by cell volume. J Gen Physiol 1999;113:57-70.
16. Gong W, Xu H, Shimizu T, Morishima S, Tanabe S, Tachibe T et al. ClC-3-independent, PKC-dependent activity of volume-sensitive Cl channel in mouse ventricular cardiomyocytes. Cell Physiol Biochem 2004;14:213-224.
17. Spiegel S, Milstien S. Sphingosine 1-phosphate, a key cell signaling molecule. J Biol Chem 2002;277:25851-25854.
18. Levade T, Auge N, Veldman RJ, Cuvillier O, Negre-Salvayre A, Salvayre R. Sphingolipid mediators in cardiovascular cell biology and pathology. Circ Res 2001;89:957-968.
19. Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9:139-150.
20. Chatterjee S, Kolmakova A, Miller M. The role of the phospholipid sphingomyelin in heart disease. Curr Opin Investig Drugs 2006;7:219-228.
21. Mulders AC, Hendriks-Balk MC, Mathy MJ, Michel MC, Alewijnse AE, Peters SL. Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin II. Arterioscler Thromb Vasc Biol 2006;26:2043- 2048.
22. Tanimoto T, Lungu AO, Berk BC. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res 2004;94:1050- 1058.
23. Zhang DX, Zou AP, Li PL. Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries. Am J Physiol Heart Circ Physiol 2003;284:H605-H612.
24. Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 1997;272: 11369-11377.
25. Gudz TI, Tserng KY, Hoppel CL. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem 1997;272:24154-24158.
26. Cl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes. Fundam Clin Pharmacol 2004;18:531-538.
27. Wijesinghe DS, Allegood JC, Gentile LB, Fox TE, Kester M, Chalfant CE. Use of high pressure liquid chromatography, electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels. J Lipid Res 2009; doi:10.1194/jlr.D000430. Published online ahead of print 4 August 2009.
28. Merrill AH Jr, Sullards MC, Allegood JC, Kelly S, Wang E. Sphingolipidomics: highthroughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods 2005;36:207-224.
29. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996;274:1855-1859.
30. Tseng GN. Cell swelling increases membrane conductance of canine cardiac cells: evidence for a volume-sensitive Cl channel. Am J Physiol 1992;262:C1056-C1068.
31. Bielawska A, Crane HM, Liotta D, Obeid LM, Hannun YA. Selectivity of ceramidemediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem 1993; 268:26226-26232.
32. Moreira PI, Custodio J, Moreno A, Oliveira CR, Santos MS. Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem 2006;281:10143-10152.
33. Siskind LJ, Kolesnick RN, Colombini M. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J Biol Chem 2002;277:26796-26803.
34. Clemo HF, Stambler BS, Baumgarten CM. Swelling-activated chloride current is persistently activated in ventricular myocytes from dogs with tachycardia-induced congestive heart failure. Circ Res 1999;84:157-165.
35. + channel dysfunction. Cell Physiol Biochem 2007;20:429-440.
36. + channel by ceramide: evidence for ubiquitinmediated lysosomal degradation. J Cell Sci 2005;118:5325-5334.
37. Ito Y, Sato S, Ohashi T, Nakayama S, Shimokata K, Kume H. Reduction of airway anion secretion via CFTR in sphingomyelin pathway. Biochem Biophys Res Commun 2004;324:901-908.
38. Milescu M, Vobecky J, Roh SH, Kim SH, Jung HJ, Kim JI et al. Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol 2007;130:497-511.
39. Ramu Y, Xu Y, Lu Z. Enzymatic activation of voltage-gated potassium channels. Nature 2006;442:696-699.
40. - channel function caused by enzymatic hydrolysis of sphingomyelin. Proc Natl Acad Sci USA 2007;104:6448-6453.
41. Browe DM, Baumgarten CM. ACh activates volume-sensitive Cl current via mitochondrial complex III reactive oxygen species in rabbit ventricular myocytes. (Abstract). Biophys J 2007;92(Suppl. 1):460a.
42. Yi F, Zhang AY, Janscha JL, Li PL, Zou AP. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int 2004;66:1977-1987.
43. Takeda S, Mitsutake S, Tsuji K, Igarashi Y. Apoptosis occurs via the ceramide recycling pathway in human HaCaT keratinocytes. J Biochem 2006;139:255-262.
44. Bielawska AE, Shapiro JP, Jiang L, Melkonyan HS, Piot C, Wolfe CL et al. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol 1997;151:1257-1263.
45. Gulbins E, Li PL. Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 2006;290:R11-R26.
46. Doehner W, Bunck AC, Rauchhaus M, von Haehling S, Brunkhorst FM, Cicoira M et al. Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow. Eur Heart J 2007;28:821-828.