β3-adrenoceptor is the predominant β-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 3, 2005, Pages 1644-1650

  Rouget, C ^a,b,f   Bardou, M ^a,e   Breuiller Fouche M ^b   Loustalot, C ^c   Qi, H ^a,b   Naline, E ^a   Croci, T ^d   Cabrol, D ^b   Advenier, C ^a   Leroy, M J ^b  

^a U de Rech de l'Enseignement Sup   (France)

^b Port Royal Maternity Hospital ^*  (France)

^c HÔPITAL DU BOCAGE   (France)

^d Sanofi Aventis Foundation   (Italy)

^e UNIVERSITÉ DE BOURGOGNE   (France)

^f U Form Rech Biomedicale Saints P   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; ETHYLAMINE; N (7 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YL)METHYL 2 HYDROXY 2 (3 CHLOROPHENYL)ETHANAMINE; SALBUTAMOL; SR 59119A; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ETHANOLAMINE DERIVATIVE; MESSENGER RNA; TETRALIN DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MOLECULAR DYNAMICS; MYOMETRIUM; PREGNANCY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; BINDING SITE; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; PHYSIOLOGY; UTERUS CONTRACTION;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BINDING SITES; BLOTTING, WESTERN; ETHANOLAMINES; FEMALE; GENE EXPRESSION; HUMANS; MYOMETRIUM; PREGNANCY; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; RNA, MESSENGER; TETRAHYDRONAPHTHALENES; UP-REGULATION; UTERINE CONTRACTION;

EID: 20144389440     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0233     Document Type: Article

References (45)

1. Goldenberg RL, Rouse DJ 1998 Prevention of premature birth. N Engl J Med 339:313-320
2. Ananth CV, Misra DP, Demissie K, Smulian JC 2001 Rates of preterm delivery among black women and white women in the United States over two decades: an age-period-cohort analysis. Am J Epidemiol 154:657-665
3. The Canadian Preterm Labor Investigators Group 1992 Treatment of preterm labor with the β-adrenergic agonist ritodrine. N Engl J Med 327:308-312
4. Berkman ND, Thorp Jr JM, Lohr KN, Carey TS, Hartmann KE, Gavin NI, Hasselblad V, Idicula AE 2003 Tocolytic treatment for the management of preterm labor: a review of the evidence. Am J Obstet Gynecol 188:1648-1659
5. Bottari SP, Vokaer A, Kaiver E, Lescrainier JP, Vauquelin G 1985 Regulation of α- and β-adrenergic receptor subclasses by gonadal steroids in human myometrium. Acta Physiol Hung 65:335-346
6. Engstrom T, Bratholm P, Vilhardt H, Christensen NJ 1997 Effect of pregnancy on rat myometrial β2-adrenoceptor mRNA and isoproterenol-induced relaxation of isolated uterine strips. J Endocrinol 153:393-399
7. Larsen JJ 1979 β-Adrenoceptors in the pregnant and non-pregnant myometrium of the goat and cow. Acta Pharmacol Toxicol (Copenh) 44:132-138
8. 125I]- iodocyanopindolol binding. Gynecol Obstet Invest 24:28-37
9. Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD 1989 Molecular characterization of the human β3-adrenergic receptor. Science 245:1118-1121
10. Bardou M, Loustalot C, Cortijo J, Simon B, Naline E, Dumas M, Esteve S, Croci T, Chalon P, Frydman R, Sagot P, Manara L, Morcillo EJ, Advenier C 2000 Functional, biochemical and molecular biological evidence for a possible β(3)-adrenoceptor in human near-term myometrium. Br J Pharmacol 130:1960-1966
11. Vivat V, Cohen-Tannoudji J, Revelli JP, Muzzin P, Giacobino JP, Maltier JP, Legrand C 1992 Progesterone transcriptionally regulates the β2-adrenergic receptor gene in pregnant rat myometrium. J Biol Chem 267:7975-7978
12. Maltier JP, Benghan-Eyene Y, Legrand C 1989 Regulation of myometrial β2-adrenergic receptors by progesterone and estradiol-17β in late pregnant rats. Biol Reprod 40:531-540
13. Leroy MJ, Cedrin I, Breuiller M, Giovagrandi Y, Ferre F 1989 Correlation between selective inhibition of the cyclic nucleotide phosphodiesterases and the contractile activity in human pregnant myometrium near term. Biochem Pharmacol 38:9-15
14. Dennedy MC, Friel AM, Gardeil F, Morrison JJ 2001 β-3 versus β-2 adrenergic agonists and preterm labour: in vitro uterine relaxation effects. BJOG 108:605-609
15. Rouget C, Breuiller-Fouche M, Mercier FJ, Leroy MJ, Loustalot C, Naline E, Frydman R, Croci T, Morcillo EJ, Advenier C, Bardou M 2004 The human near-term myometrial β3-adrenoceptor but not the β2-adrenoceptor is resistant to desensitisation after sustained agonist stimulation. Br J Pharmacol 141:831-841
16. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
17. Roberts SJ, Molenaar P, Summers RJ 1993 Characterization of propranolol-resistant (-)-[125I]-cyanopindolol binding sites in rat soleus muscle. Br J Pharmacol 109:344-352
18. Cheng Y, Prusoff WH 1973 Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (150) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108
19. Mehats C, Tanguy G, Dallot E, Robert B, Rebourcet R, Ferre F, Leroy MJ 1999 Selective up-regulation of phosphodiesterase-4 cyclic adenosine 3′,5′-monophosphate (cAMP)-specific phosphodiesterase variants by elevated cAMP content in human myometrial cells in culture. Endocrinology 140:3228-3237
20. Roberts SJ, Papaioannou M, Evans BA, Summers RJ 1997 Functional and molecular evidence for β1-, β2- and β3-adrenoceptors in human colon. Br J Pharmacol 120:1527-1535
21. Gussow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL 1987 The human β2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol 139:3132-3138
22. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
23. Dattel BJ, Lam F, Roberts JM 1986 Failure to demonstrate decreased β-adrenergic receptor concentration or decreased agonist efficacy in term or preterm human parturition. Am J Obstet Gynecol 154:450-456
24. Chanrachakul B, Matharoo-Ball B, Turner A, Robinson G, Broughton-Pipkin F, Arulkumaran S, Khan RN 2003 Reduced expression of immunoreactive β2-adrenergic receptor protein in human myometrium with labor. J Clin Endocrinol Metab 88:4997-5001
25. Crankshaw DJ, Ruzycky AL 1984 Characterization of putative β-adrenoceptors in the myometrium of the pregnant ewe: correlation between the binding of [3H] dihydroalprenolol and the inhibition of myometrial contractility in vitro. Biol Reprod 30:609-618
26. Maltier JP, Legrand C 1988 Characterization of β-adrenoceptors in myometrium of preparturient rats. Fundam Clin Pharmacol 2:369-383
27. Gsell S, Eschenhagen T, Kaspareit G, Nose M, Scholz H, Behrens O, Wieland T 2000 Apparent up-regulation of stimulatory G-protein α subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression. FASEB J 14:17-26
28. Engelhardt S, Zieger W, Kassubek J, Michel MC, Lohse MJ, Brodde OE 1997 Tocolytic therapy with fenoterol induces selective down-regulation of β-adrenergic receptors in human myometrium. J Clin Endocrinol Metab 82:1235-1242
29. Hadcock JR, Malbon CC 1991 Regulation of receptor expression by agonists: transcriptional and post-transcriptional controls. Trends Neurosci 14:242-247
30. Hadcock JR, Port JD, Malbon CC 1991 Cross-regulation between G-protein-mediated pathways. Activation of the inhibitory pathway of adenylylcylclase increases the expression of β2-adrenergic receptors. J Biol Chem 266:11915-11922
31. Strosberg AD, Pietri-Rouxel F 1996 Function and regulation of the β3-adrenoceptor. Trends Pharmacol Sci 17:373-381
32. Rathi S, Karerounian S, Banwait K, Schulz S, Waldman SA, Rattan S 2003 Functional and molecular characterization of β-adrenoceptors in the internal anal sphincter. J Pharmacol Exp Ther 305:615-624
33. Bardou M, Dousset B, Deneux-Tharaux C, Smadja C, Naline E, Chaput JC, Naveau S, Manara L, Croci T, Advenier C 1998 In vitro inhibition of human colonic motility with SR 59119A and SR 59104A: evidence of a β3-adrenoceptor-mediated effect. Eur J Pharmacol 353:281-287
34. Naline E, Bardou M, Devillier P, Molimard M, Dumas M, Chalon P, Manara L, Advenier C 2000 Inhibition by SR 59119A of isoprenaline-, forskolin- and VIP-induced relaxation of human isolated bronchi. Pulm Pharmacol Ther 13:167-174
35. Legrand C, Maltier JP, Benghan-Eyene Y 1987 Rat myometrial adrenergic receptors in late pregnancy. Biol Reprod 37:641-650
36. Hatjis CG, Grogan DM 1989 Pregnancy-induced changes in the interaction of guinea pig myometrial β-adrenergic receptors with 1-isoproterenol. Am J Obstet Gynecol 161:1633-1636
37. Ferre F, Uzan M, Janssens Y, Tanguy G, Jolivet A, Breuiller M, Sureau C, Cedard L 1984 Oral administration of micronized natural progesterone in late human pregnancy. Effects on progesterone and estrogen concentrations in the plasma, placenta, and myometrium. Am J Obstet Gynecol 148:26-34
38. Malo A, Puerta M 2001 Oestradiol and progesterone change β3-adrenergic receptor affinity and density in brown adipocytes. Eur J Endocrinol 145:87-91
39. Kaumann AJ 1989 Is there a third heart β-adrenoceptor? Trends Pharmacol Sci 10:316-320
40. Gauthier C, Tavernier G, Charpentier F, Langin D, Le Marec H 1996 Functional β3-adrenoceptor in the human heart. J Clin Invest 98:556-562
41. van Baak MA, Hul GB, Toubro S, Astrup A, Gottesdiener KM, DeSmet M, Saris WH 2002 Acute effect of L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure in obese men. Clin Pharmacol Ther 71:272-279
42. Haesler E, Golay A, Guzelhan C, Schutz Y, Hartmann D, Jequier E, Felber JP 1994 Effect of a novel β-adrenoceptor agonist (Ro 40-2148) on resting energy expenditure in obese women. Int J Obes Relat Metab Disord 18:313-322
43. Goldberg GR, Prentice AM, Murgatroyd PR, Haines W, Tuersley MD 1995 Effects on metabolic rate and fuel selection of a selective β-3 agonist (ICI D7114) in healthy lean men. Int J Obes Relat Metab Disord 19:625-631
44. Berg G, Andersson RG, Ryden G 1985 β-Adrenergic receptors in human myometrium during pregnancy: changes in the number of receptors after β-mimetic treatment. Am J Obstet Gynecol 151:392-396
45. Langin D, Tavernier G, Lafontan M 1995 Regulation of β3-adrenoceptor expression in white fat cells. Fundam Clin Pharmacol 9:97-106