An α-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 276, Issue 5 45-5, 1999, Pages

  Kim, Song Jung ^a   Iizuka, Kenji ^a   Kelly, Ralph A ^b   Geng, Yong Jian ^a   Bishop, Sanford P ^a   Yang, Guiping ^a   Kudej, Amelia ^a   McConnell, Bradley K ^c   Seidman, Christine E ^d   Seidman, Jonathan G ^c   Vatner, Stephen F ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Calcium; Transgenic mice

Indexed keywords

MYOSIN HEAVY CHAIN;

ANIMAL CELL; ARTICLE; GENE MUTATION; HEART FUNCTION; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HEART WORK; HYPERTROPHIC CARDIOMYOPATHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 20244368785     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.276.5.h1780     Document Type: Article

References (29)

1. Bailey, B. A., K. Dipla, S. Li, and S. R. Houser. Cellular basis of contractile derangements of hypertrophied feline ventricular myocytes. J. Mol. Cell. Cardiol. 29: 1823-1835, 1997.
2. Bailey, B. A., and S. R. Houser. Calcium transients in feline left ventricular myocytes with hypertrophy induced by slow progressive pressure overload. J. Mol. Cell. Cardiol. 24: 365-375, 1992.
3. Bailey, B. A., and S. R. Houser. Sarcoplasmic reticulum-related changes in cytosolic calcium in pressure-overload-induced feline LV hypertrophy. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H2009-H2016, 1993.
4. 2+ handling is an early manifestation of pressure-overload hypertrophy in rat hearts. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H228-H2234, 1996.
5. 2+-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ. Res. 66: 554-564, 1990.
6. 2-adrenoceptors in single myocytes from human ventricle. Circulation 88: 854-863, 1993.
7. 403Arg →Gln mutation. Circulation 86: 345-352, 1992.
8. Fananapazir, L., and N. D. Epstein. Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical β-myosin heavy chain gene mutations. Circulation 89: 22-32, 1994.
9. Geisterfer-Lowrance, A. A. T., M. Christe, D. A. Conner, J. S. Ingwall, F. J. Schoen, C. E. Seidman, and J. G. Seidman. A mouse model of familial hypertrophic cardiomyopathy. Science 272: 731-734, 1996.
10. Geisterfer-Lowrance, A. A. T., S. Kass, G. Tanigawa, H. P. Vosberg, W. McKenna, C. E. Seidman, and J. G. Seidman. A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation. Cell 62: 999-1006, 1990.
11. Gwathmey, J. K., and J. P. Morgan. Altered calcium handling in experimental pressure-overload hypertrophy in the ferret. Circ. Res. 57: 836-843, 1985.
12. Gwathmey, J. K., S. E. Warren, G. M. Briggs, L. Copelas, M. D. Feldman, P. J. Phillips, M. Callahan, F. J. Schoen, W. Grossman, and J. P. Morgan. Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole. J. Clin. Invest. 87: 1023-1031, 1991.
13. Ito, N., J. Bartunek, K. W. Spitzer, and B. H. Lorell. Effects of the nitric oxide donor sodium nitroprusside on intracellular pH and contraction in hypertrophied myocytes. Circulation 95: 2303-2311, 1997.
14. Jasmin, G., and L. Proschek. Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster. Can. J. Physiol. Pharmacol. 62: 891-898, 1984.
15. Jasmin, G., and L. Proschek. Hereditary polymyopathy and cardiomyopathy in the Syrian hamster. I. Progression of heart and skeletal muscle lesions in the UM-X7.1 line. Muscle Nerve 5: 20-25, 1982.
16. Kadambi, V. J., S. Ponniah, J. M. Harrer, B. D. Hoit, G. W. Dorn II, R. A. Walsh, and E. G. Kranias. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J. Clin. Invest. 97: 533-539, 1996.
17. 2+-ATPase protein levels. Circ. Res. 77: 759-764, 1995.
18. 2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage. J. Clin. Invest. 83: 1102-1108, 1989.
19. Lamers, J. M. J., and F. T. Stinis. Defective calcium pump in the sarcoplasmic reticulum of the hypertrophied rabbit heart. Life Sci. 24: 2313-2320, 1979.
20. Lankford, E. B., N. D. Epstein, L. Fananapazir, and H. L. Sweeney. Abnormal contractile properties of muscle fibers expressing β-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J. Clin. Invest. 95: 1409-1414, 1995.
21. 2+-ATPaSe and function of sarcoplasmic reticulum during cardiac hypertrophy. Am. J. Physiol. Suppl. (Oct.) 261: 23-26, 1991.
22. 92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocyte contractility. Circ. Res. 81: 76-85, 1997.
23. Maron, B. J., T. Anan, and W. Roberts. Quantitative analysis of the distribution of cardiac muscle cell disorganization in the left ventricular wall of patients with hypertrophic cardiomyopathy. Circulation 63: 882-894, 1981.
24. Schwartz, K., L. Carrier, P. Guicheney, and M. Komajda. Molecular basis of familiar cardioymyopathies. Circulation 91: 532-540, 1995.
25. Sen, L., M. O'Neill, J. D. Marsh, and T. W. Smith. Myocyte structure, function, and calcium kinetics in the cardiomyopathic hamster heart. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1533-H1543, 1990.
26. Sweeney, H. L., A. J. Straceski, L. A. Leinwand, B. A. Tikunov, and L. Faust. Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction. J. Biol. Chem. 269: 1603-1605, 1994.
27. Tsutsui, H., Y. Ishibashi, K. Imanaka-Yoshida, S. Yamamoto, T. Yoshida, M. Sugimachi, Y. Urabe, and A. Takeshita. Alterations in sarcoplasmic reticulum calcium-storing proteins in pressure-overload cardiac hypertrophy. Am. J. Physiol. 272 (Heart Circ. Physiol. 41): H168-H175, 1997.
28. Watkins, H., J. G. Seidman, and C. E. Seidman. Familiar hypertrophic cardiomyopathy: a genetic model of cardiac hypertrophy. Hum. Mol. Genet. 4:1721-1727, 1995.
29. 2+ concentration in nonbeating guinea pig ventricular myocytes. Circ. Res. 66: 234-241, 1990.