Right ventricular beneficial effects of intracoronary SERCA2a gene transfer in an experimental model of heart failure

Folia Biologica

Volumn 56, Issue 1, 2010, Pages 1-8

  Molina, E J ^a   Gupta, D ^a   Palma, J ^a   Gaughan, J P ^a   Macha, Mahender ^b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Calcium metabolism; Heart failure; Pharmacogenomics

Indexed keywords

BETA GALACTOSIDASE; G PROTEIN COUPLED RECEPTOR KINASE 2; INTERLEUKIN 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE TRANSFER; HEART FAILURE; HEART RIGHT VENTRICLE; NONHUMAN; PROTEIN EXPRESSION; RAT; VIRAL GENE DELIVERY SYSTEM; ADENOVIRIDAE; ANIMAL; GENETICS; HEART VENTRICLE; HUMAN; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT; TRANSGENE; VIRUS REPLICATION;

ANIMALIA; RATTUS;

ADENOVIRIDAE; ANIMALS; BIOLOGICAL MARKERS; GENE TRANSFER TECHNIQUES; HEART FAILURE; HEART VENTRICLES; HUMANS; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TRANSGENES; VIRUS REPLICATION;

EID: 77949293432     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Arai, M., Matsui, H., Periasamy, M. (1994) Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ. Res. 74, 555-564.
2. Aukrust, P., Ueland, T., Lien, E., Bendtzen, K., Müller, F., Andreassen, A. K., Nordøy, I., Aass, H., Espevik, T., Simonsen, S., Frøland, S. S., Gullestad, L. (1999) Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am. J. Cardiol. 83, 376-382.
3. 2+-ATPase increases cardiac contractility in transgenic mouse hearts. Circ. Res. 83, 1205-1214.
4. Bristow, M. R (2000) Beta-adrenergic receptor blockade in chronic heart failure. Circulation 101, 558-569.
5. 2+ sparks. Cell Calcium 20, 129-140.
6. Cook, S. A., Sugden, P. H., Clerk, A. (1999) Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischemic heart disease. J. Mol. Cell Cardiol. 31, 1429-1434.
7. Croyle, M. A., Anderson, D. J., Roessler, B. J., Amidon, G. L. (1998) Development of a highly efficient purification process for recombinant adenoviral vectors for oral gene delivery. Pharmaceut. Dev. Tech. 3, 365-372.
8. Davies, C. H., Davia, K., Bennett, J. G., Pepper, J. R., Poole-Wilson, P. A., Harding, S. E. (1995) Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation 92, 2540-2549.
9. del Monte, F., Harding, S. E., Schmidt, U., Matsui, T., Kang, Z. B., Dec, G. W., Gwathmey, J. K., Rosenzweig, A., Hajjar, R. J. (1999) Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100, 2308-2311.
10. 2+)-ATPase in a rat model of heart failure. Circulation 104, 1424-1429.
11. del Monte, F., Butler, K., Boecker, W., Gwathmey, J. K., Hajjar, R. J. (2002) Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure. Physiol. Genomics 9, 49-56.
12. Feuerstein, G. Z., Young, P. R. (2000) Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc. Res. 45, 560-569.
13. 2+ transients. Circulation 96, 400-403.
14. Gupta, D., Palma, J., Molina, E., Gaughan, J. P., Long, W., Houser, S., Macha, M. (2008) Improved exercise capacity and reduced systemic inflammation after adenoviral-mediated SERCA-2a gene transfer. J. Surg. Res. 145, 257-265.
15. Gwathmey, J. K., Copelas, L., MacKinnon, R., Schoen, F. J., Feldman, M. D., Grossman, W., Morgan, J. P. (1987) Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ. Res. 61, 70-76.
16. Hajjar, R. J., Kang, J. X., Gwathmey, J. K., Rosenzweig, A. (1997) Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes. Circulation 95, 423-429.
17. Hayashida, W., Kihara, Y., Yasaka, A., Inagaki, K., Iwanaga, Y., Sasayama, S. (2001) Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat hearts. J. Mol. Cell Cardiol. 33, 733-744.
18. 2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. J. Clin. Invest. 100, 380-389.
19. Jayasankar, V., Woo, Y. J., Bish, L. T., Pirolli, T. J., Chatterjee, S., Berry, M. F., Burdick, J., Gardner, T. J., Sweeney, H. L. (2003) Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure. Circulation 108, II-230-236.
20. Kang, P. M., Izumo, S. (2000) Apoptosis and heart failure. Circ. Res. 86, 1107-1113.
21. Kubo, H., Margulies, K. B., Piacentino, V., Gaughan, J. P., Houser, S. (2001) Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation 104, 1012-1018.
22. Latif, N., Khan, M. A., Birks, E., O'Farrell, A., Westbrook, J., Dunn, M. J., Yacoub, M. H. (2000) Upregulation of the Bcl-2 family of proteins in end stage heart failure. J. Am. Coll. Cardiol. 35, 1769-1777.
23. Levine, B., Kalman, J., Mayer, L., Fillit, H. M., Packer, M. (1990) Elevated circulating levels of tumor necrosis factor in severe congestive heart failure. N. Engl. J. Med. 323, 236-241.
24. Matsumori, A., Yamada, T., Suzuki, H., Matoba, Y., Sasayama, S. (1994) Increased circulating cytokines in patients with myocarditis and cardiomyopathy. Br. Heart J. 72, 561-566.
25. Miyamoto, M. I., del Monte, F., Schmidt, U., DiSalvo, T. S., Kang, Z. B., Matsui, T., Guerrero, J. L., Gwathmey, J. K., Rosenzweig, A., Hajjar, R. J. (2000) Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA 97, 793-798.
26. Molina, E. J., Gupta, D., Palma, J., Torres, D., Gaughan, J. P., Houser, S., Macha, M. (2009a) Novel experimental model of pressure overload hypertrophy in rats. J. Surg. Res. 153, 287-294.
27. Molina, E. J., Palma, J., Gupta, D., Gaughan, J. P., Houser, S., Macha, M. (2009b) Right ventricular effects of intracoronary delivery of mesenchymal stem cells (MSC) in an animal model of pressure overload heart failure. Biomed. Pharmacother. 63, 331-336.
28. Morgan, J. P., Erny, R. E., Allen, P. D., Grossman, W., Gwathmey, J. K. (1990) Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81, III-21-32.
29. Morgan, J. P. (1991) Abnormal intercellular modulation of calcium as a major cause of cardiac contractility dysfunction. N. Engl. J. Med. 325, 625-632.
30. Schwartz, K., Mercadier, J. J. (1996) Molecular and cellular biology of heart failure. Curr. Opin. Cardiol. 11, 227-236.
31. Sopontammarak, S., Aliharoob, A., Ocampo, C., Arcilla, R. A., Gupta, M. P., Gupta, M. (2005) Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy. Cell Biochem. Biophys. 43, 61-76.
32. Yue, D. T. (1997) Quenching the spark in the heart. Science 276, 755-756.