-
1
-
-
34047103363
-
A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis
-
DOI 10.1038/2005, PII NG2005
-
Y Miyamoto A Mabuchil DQ Shi T Kubo Y Takatori S Saito M Fujioka A Sudo A Uchida S Yamamoto K Ozaki M Takigawa T Tanaka Y Nakamura Q Jiang S Ikegawa 2007 A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis Nat Genet 39 529 533 10.1038/2005 10.1038/2005 1:CAS:528:DC%2BD2sXjsV2hs7Y%3D 17384641 (Pubitemid 46514783)
-
(2007)
Nature Genetics
, vol.39
, Issue.4
, pp. 529-533
-
-
Miyamoto, Y.1
Mabuchi, A.2
Shi, D.3
Kubo, T.4
Takatori, Y.5
Saito, S.6
Fujioka, M.7
Sudo, A.8
Uchida, A.9
Yamamoto, S.10
Ozaki, K.11
Takigawa, M.12
Tanaka, T.13
Nakamura, Y.14
Jiang, Q.15
Ikegawa, S.16
-
2
-
-
0031464970
-
Cartilage-derived morphogenetic protein-1
-
DOI 10.1016/S1357-2725(97)00025-3, PII S1357272597000253
-
FP Luyten 1997 Cartilage-derived morphogenetic protein-1 Int J Biochem Cell Biol 29 1241 1244 10.1016/S1357-2725(97)00025-3 10.1016/S1357-2725(97) 00025-3 1:CAS:528:DyaK1cXltFejtw%3D%3D 9451821 (Pubitemid 28021709)
-
(1997)
International Journal of Biochemistry and Cell Biology
, vol.29
, Issue.11
, pp. 1241-1244
-
-
Luyten, F.P.1
-
3
-
-
0032905901
-
Mechanisms of GDF-5 action during skeletal development
-
1:CAS:528:DyaK1MXisFWmsbs%3D 10021348
-
PH Francis-West A Abdelfattah P Chen C Allen J Parish R Ladher S Allen S MacPherson FP Luyten CW Archer 1999 Mechanisms of GDF-5 action during skeletal development Development 126 1305 1315 1:CAS:528:DyaK1MXisFWmsbs%3D 10021348
-
(1999)
Development
, vol.126
, pp. 1305-1315
-
-
Francis-West, P.H.1
Abdelfattah, A.2
Chen, P.3
Allen, C.4
Parish, J.5
Ladher, R.6
Allen, S.7
MacPherson, S.8
Luyten, F.P.9
Archer, C.W.10
-
4
-
-
0034886062
-
Bone morphogenetic proteins in the development and healing of synovial joints
-
DOI 10.1053/sarh.2001.24875
-
CJ Edwards PH Frances-West 2001 Bone morphogenetic proteins in the development and healing of synovial joints Semin Arthritis Rheum 31 33 42 10.1053/sarh.2001.24875 10.1053/sarh.2001.24875 1:CAS:528:DC%2BD3MXms1Sqs7o%3D 11503137 (Pubitemid 32756170)
-
(2001)
Seminars in Arthritis and Rheumatism
, vol.31
, Issue.1
, pp. 33-42
-
-
Edwards, C.J.1
Francis-West, P.H.2
-
5
-
-
2942525503
-
Multiple effects of GDF5 deficiency on skeletal tissues, implications for therapeutic bioengineering
-
10.1023/B:ABME.0000017549.57126.51 10.1023/B:ABME.0000017549.57126.51 15095821
-
B Mikic 2004 Multiple effects of GDF5 deficiency on skeletal tissues, implications for therapeutic bioengineering Ann Biomed Eng 32 466 476 10.1023/B:ABME.0000017549.57126.51 10.1023/B:ABME.0000017549.57126.51 15095821
-
(2004)
Ann Biomed Eng
, vol.32
, pp. 466-476
-
-
Mikic, B.1
-
6
-
-
20344385511
-
A single residue of GDF-5 defines binding specificity to BMP receptor IB
-
DOI 10.1016/j.jmb.2005.04.015, PII S0022283605004146
-
J Nickel A Kotzsch W Sebald TD Mueller 2005 A single residue of GDF5 defines binding specificity to BMP receptor IB J Mol Biol 349 933 947 10.1016/j.jmb.2005.04.015 10.1016/j.jmb.2005.04.015 1:CAS:528: DC%2BD2MXltVeltrs%3D 15890363 (Pubitemid 40779617)
-
(2005)
Journal of Molecular Biology
, vol.349
, Issue.5
, pp. 933-947
-
-
Nickel, J.1
Kotzsch, A.2
Sebald, W.3
Mueller, T.D.4
-
7
-
-
0030481707
-
Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family
-
1:CAS:528:DyaK2sXhtVyjsr4%3D 9012517
-
EE Storm DM Kingsley 1996 Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family Development 122 3969 3979 1:CAS:528:DyaK2sXhtVyjsr4%3D 9012517
-
(1996)
Development
, vol.122
, pp. 3969-3979
-
-
Storm, E.E.1
Kingsley, D.M.2
-
8
-
-
0029936784
-
A human chondrodysplasia due to a mutation in a TGF-β superfamily member
-
DOI 10.1038/ng0396-315
-
JT Thomas K Lin M Nandedkar M Camargo J Cervenka FP Luyten 1996 A human chondrodysplasia due to a mutation in a TGF-beta superfamily member Nat Genet 12 315 317 10.1038/ng0396-315 10.1038/ng0396-315 1:CAS:528:DyaK28XhvVSgtbw%3D 8589725 (Pubitemid 26080093)
-
(1996)
Nature Genetics
, vol.12
, Issue.3
, pp. 315-317
-
-
Thomas, J.T.1
Lin, K.2
Nandedkar, M.3
Camargo, M.4
Cervenka, J.5
Luyten, F.P.6
-
9
-
-
33847716756
-
Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5
-
DOI 10.1016/j.joca.2006.09.003, PII S1063458406002688
-
M Harada M Takahara P Zhe M Otsuji Y Iuchi M Takagi T Ogino 2007 Developmental failure of the intra-articular ligaments in mice with absence of growth differentiation factor 5 Osteoarthritis Cartilage 15 468 474 10.1016/j.joca.2006.09.003 10.1016/j.joca.2006.09.003 1:STN:280: DC%2BD2s7msFaqug%3D%3D 17052922 (Pubitemid 46381561)
-
(2007)
Osteoarthritis and Cartilage
, vol.15
, Issue.4
, pp. 468-474
-
-
Harada, M.1
Takahara, M.2
Zhe, P.3
Otsuji, M.4
Iuchi, Y.5
Takagi, M.6
Ogino, T.7
-
10
-
-
34548803060
-
A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice
-
DOI 10.1093/hmg/ddm195
-
H Masuya K Nishida T Furuichi H Toki G Nishimura H Kawabata H Yokoyama A Yoshida S Tominaga J Nagano 2007 A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice Hum Mol Genet 16 2366 2375 10.1093/hmg/ddm195 10.1093/hmg/ddm195 1:CAS:528:DC%2BD2sXht1Gls7vO 17656374 (Pubitemid 47430455)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.19
, pp. 2366-2375
-
-
Masuya, H.1
Nishida, K.2
Furuichi, T.3
Toki, H.4
Nishimura, G.5
Kawabata, H.6
Yokoyama, H.7
Yoshida, A.8
Tominaga, S.9
Nagano, J.10
Shimizu, A.11
Wakana, S.12
Gondo, Y.13
Noda, T.14
Shiroishi, T.15
Ikegawa, S.16
-
11
-
-
0032908146
-
Expression and function of gdf-5 during digit skeletogenesis in the embryonic chick leg bud
-
DOI 10.1006/dbio.1998.9129
-
R Merinoa D Maciasb Y Gañanb AN Economidesc X Wangc Q Wuc N Stahlc KT Sampathd P Varonaa JM Hurlea 1999 Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud Dev Biol 206 33 45 10.1006/dbio.1998.9129 10.1006/dbio.1998.9129 (Pubitemid 29069872)
-
(1999)
Developmental Biology
, vol.206
, Issue.1
, pp. 33-45
-
-
Merino, R.1
Macias, D.2
Ganan, Y.3
Economides, A.N.4
Wang, X.5
Wu, Q.6
Stahl, N.7
Sampath, K.T.8
Varona, P.9
Hurle, J.M.10
-
12
-
-
0001199647
-
Generalized osteoarthritis and Heberden's nodes
-
10.1136/bmj.1.4751.181 10.1136/bmj.1.4751.181 1:STN:280: DyaG38%2Fis1Wrug%3D%3D 14896078
-
JH Kellgren R Moore 1952 Generalized osteoarthritis and Heberden's nodes BMJ 1 181 187 10.1136/bmj.1.4751.181 10.1136/bmj.1.4751.181 1:STN:280: DyaG38%2Fis1Wrug%3D%3D 14896078
-
(1952)
BMJ
, vol.1
, pp. 181-187
-
-
Kellgren, J.H.1
Moore, R.2
-
13
-
-
0029132296
-
Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization
-
10.1002/art.1780380817 10.1002/art.1780380817 1:STN:280: DyaK2MzmslSktQ%3D%3D 7639811
-
SA Oliveria DT Felson JI Reed PA Cirillo AM Walker 1995 Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization Arthritis Rheum 38 1134 1141 10.1002/art.1780380817 10.1002/art.1780380817 1:STN:280:DyaK2MzmslSktQ%3D%3D 7639811
-
(1995)
Arthritis Rheum
, vol.38
, pp. 1134-1141
-
-
Oliveria, S.A.1
Felson, D.T.2
Reed, J.I.3
Cirillo, P.A.4
Walker, A.M.5
-
14
-
-
0031918786
-
Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis
-
DOI 10.1359/jbmr.1998.13.3.383
-
L Erlacher J McCartney E Piek P ten Dijke M Yanagishita H Oppermann FP Luyten 1998 Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis J Bone Miner Res 13 383 392 10.1359/jbmr.1998.13.3.383 10.1359/jbmr.1998.13.3.383 1:STN:280: DyaK1c7osVamsg%3D%3D 9525338 (Pubitemid 28146220)
-
(1998)
Journal of Bone and Mineral Research
, vol.13
, Issue.3
, pp. 383-392
-
-
Erlacher, L.1
Mccartney, J.2
Piek, E.3
Ten Dijke, P.4
Yanagishita, M.5
Oppermann, H.6
Luyten, F.P.7
-
15
-
-
0030742587
-
Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-b gene family
-
10.1172/JCI119537 10.1172/JCI119537 1:CAS:528:DyaK2sXkslKns7Y%3D 9218508
-
NM Wolfman G Hattersley K Cox AJ Celeste R Nelson N Yamaji JL Dube E DiBlasio-Smith J Nove JJ Song JM Wozney V Rosen 1997 Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-b gene family J Clin Invest 100 321 330 10.1172/JCI119537 10.1172/JCI119537 1:CAS:528:DyaK2sXkslKns7Y%3D 9218508
-
(1997)
J Clin Invest
, vol.100
, pp. 321-330
-
-
Wolfman, N.M.1
Hattersley, G.2
Cox, K.3
Celeste, A.J.4
Nelson, R.5
Yamaji, N.6
Dube, J.L.7
Diblasio-Smith, E.8
Nove, J.9
Song, J.J.10
Wozney, J.M.11
Rosen, V.12
-
16
-
-
0027631054
-
Linear body measurements of cattle before and after 20 years of selection for postweaning gain when fed two different diets
-
1:STN:280:DyaK3szlt1eguw%3D%3D 8349499
-
RP Gilbert DRC Bailey NH Shannon 1993 Linear body measurements of cattle before and after 20 years of selection for postweaning gain when fed two different diets J Anim Sci 71 1712 1720 1:STN:280:DyaK3szlt1eguw%3D%3D 8349499
-
(1993)
J Anim Sci
, vol.71
, pp. 1712-1720
-
-
Gilbert, R.P.1
Bailey, D.R.C.2
Shannon, N.H.3
-
17
-
-
0024791277
-
An efficient salt-chloroform extraction of DNA from blood and tissues
-
1:STN:280:DyaK3c7mt12rtg%3D%3D 2623762
-
R Mullenbach PJ Lagoda C Welter 1989 An efficient salt-chloroform extraction of DNA from blood and tissues Trends Genet 5 391 1:STN:280: DyaK3c7mt12rtg%3D%3D 2623762
-
(1989)
Trends Genet
, vol.5
, pp. 391
-
-
Mullenbach, R.1
Lagoda, P.J.2
Welter, C.3
-
18
-
-
0015990369
-
Sampling variance of heterozygosity and genetic distance
-
1:STN:280:DyaE2c7ktlCiuw%3D%3D 4822472
-
M Nei AK Roychoudhury 1974 Sampling variance of heterozygosity and genetic distance Genetics 76 379 390 1:STN:280:DyaE2c7ktlCiuw%3D%3D 4822472
-
(1974)
Genetics
, vol.76
, pp. 379-390
-
-
Nei, M.1
Roychoudhury, A.K.2
-
19
-
-
0005814023
-
Mathematical model for studying genetic variation in terms of restriction endonucleases
-
DOI 10.1073/pnas.76.10.5269
-
M Nei WH Li 1979 Mathematic model for studying genetic variation in terms of restriction endonuclease Proc Natl Acad Sci USA 76 5269 5273 10.1073/pnas.76.10.5269 10.1073/pnas.76.10.5269 1:CAS:528:DyaL3cXitVWn 291943 (Pubitemid 10236121)
-
(1979)
Proceedings of the National Academy of Sciences of the United States of America
, vol.76
, Issue.10
, pp. 5269-5273
-
-
Nei, M.1
Li, W.H.2
-
20
-
-
42649139571
-
Genome-wide association analysis identifies 20 loci that influence adult height
-
DOI 10.1038/ng.121, PII NG121
-
MN Weedon H Lango CM Lindgren C Wallace DM Evans M Mangino RM Freathy JRB Perry S Stevens AS Hall NJ Samani B Shields I Prokopenko M Farrall A Dominiczak T Johnson S Bergmann JS Beckmann P Vollenweider DM Waterworth V Mooser CNA Palmer AD Morris WH Ouwehand M Caulfield PB Munroe AT Hattersley MI McCarthy TM Frayling 2008 Genome-wide association analysis identifies 20 loci that influence adult height Nat Genet 40 575 583 10.1038/ng.121 10.1038/ng.121 1:CAS:528:DC%2BD1cXltFylurc%3D 18391952 (Pubitemid 351601210)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 575-583
-
-
Weedon, M.N.1
Lango, H.2
Lindgren, C.M.3
Wallace, C.4
Evans, D.M.5
Mangino, M.6
Freathy, R.M.7
Perry, J.R.B.8
Stevens, S.9
Hall, A.S.10
Samani, N.J.11
Shields, B.12
Prokopenko, I.13
Farrall, M.14
Dominiczak, A.15
Johnson, T.16
Bergmann, S.17
Beckmann, J.S.18
Vollenweider, P.19
Waterworth, D.M.20
Mooser, V.21
Palmer, C.N.A.22
Morris, A.D.23
Ouwehand, W.H.24
Zhao, J.H.25
Li, S.26
Loos, R.J.F.27
Barroso, I.28
Deloukas, P.29
Sandhu, M.S.30
Wheeler, E.31
Soranzo, N.32
Inouye, M.33
Wareham, N.J.34
Caulfield, M.35
Munroe, P.B.36
Hattersley, A.T.37
McCarthy, M.I.38
Frayling, T.M.39
more..
-
21
-
-
38649121127
-
Common variants in the GDF5-UQCC region are associated with variation in human height
-
DOI 10.1038/ng.74, PII NG74
-
S Sanna AU Jackson R Nagaraja CJ Willer WM Chen LL Bonnycastle HQ Shen N Timpson G Lettre G Usala PS Chines HM Stringham LJ Scott M Dei S Lai G Albai L Crisponi S Naitza KF Doheny EW Pugh YB Shlomo S Ebrahim DA Lawlor RN Bergman RM Watanabe M Uda J Tuomilehto J Coresh JN Hirschhorn AR Shuldiner D Schlessinger FS Collins GD Smith E Boerwinkle A Cao M Boehnke GR Abecasis KL Mohlke 2008 Common variants in the GDF5-UQCC region are associated with variation in human height Nat Genet 40 198 203 10.1038/ng.74 10.1038/ng.74 1:CAS:528: DC%2BD1cXhtl2qtrk%3D 18193045 (Pubitemid 351171401)
-
(2008)
Nature Genetics
, vol.40
, Issue.2
, pp. 198-203
-
-
Sanna, S.1
Jackson, A.U.2
Nagaraja, R.3
Willer, C.J.4
Chen, W.-M.5
Bonnycastle, L.L.6
Shen, H.7
Timpson, N.8
Lettre, G.9
Usala, G.10
Chines, P.S.11
Stringham, H.M.12
Scott, L.J.13
Dei, M.14
Lai, S.15
Albai, G.16
Crisponi, L.17
Naitza, S.18
Doheny, K.F.19
Pugh, E.W.20
Ben-Shlomo, Y.21
Ebrahim, S.22
Lawlor, D.A.23
Bergman, R.N.24
Watanabe, R.M.25
Uda, M.26
Tuomilehto, J.27
Coresh, J.28
Hirschhorn, J.N.29
Shuldiner, A.R.30
Schlessinger, D.31
Collins, F.S.32
Smith, G.D.33
Boerwinkle, E.34
Cao, A.35
Boehnke, M.36
Abecasis, G.R.37
Mohlke, K.L.38
more..
-
22
-
-
42649092874
-
Identification of ten loci associated with height highlights new biological pathways in human growth
-
DOI 10.1038/ng.125, PII NG125
-
GA Lettre AU Jackson C Gieger FR Schumacher SI Berndt S Sanna S Eyheramendy BF Voight JL Butler C Guiducci T Illig R Hackett IM Heid KB Jacobs V Lyssenko M Uda M Boehnke SJ Chanock LC Groop FB Hu B Isomaa P Kraft L Peltonen V Salomaa D Schlessinger DJ Hunter RB Hayes GR Abecasis HE Wichmann KL Mohlke JN Hirschhorn 2008 Identification of ten loci associated with height highlights new biological pathways in human growth Nat Genet 40 584 591 10.1038/ng.125 10.1038/ng.125 1:CAS:528:DC%2BD1cXltFylu70%3D 18391950 (Pubitemid 351601214)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 584-591
-
-
Lettre, G.1
Jackson, A.U.2
Gieger, C.3
Schumacher, F.R.4
Berndt, S.I.5
Sanna, S.6
Eyheramendy, S.7
Voight, B.F.8
Butler, J.L.9
Guiducci, C.10
Illig, T.11
Hackett, R.12
Heid, I.M.13
Jacobs, K.B.14
Lyssenko, V.15
Uda, M.16
Boehnke, M.17
Chanock, S.J.18
Groop, L.C.19
Hu, F.B.20
Isomaa, B.21
Kraft, P.22
Peltonen, L.23
Salomaa, V.24
Schlessinger, D.25
Hunter, D.J.26
Hayes, R.B.27
Abecasis, G.R.28
Wichmann, H.-E.29
Mohlke, K.L.30
Hirschhorn, J.N.31
more..
-
23
-
-
34548409926
-
An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage
-
DOI 10.1093/hmg/ddm174
-
L Southam J Rodriguez-lopez JM Wilkins M Pombo-suarez S Snelling JJ Gomez-reino K Charpman A Gonzalez J Loughlin 2007 An SNP in the 5¢-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage Hum Mol Genet 16 2226 2232 10.1093/hmg/ddm174 10.1093/hmg/ddm174 1:CAS:528:DC%2BD2sXpvVaitrc%3D 17616513 (Pubitemid 47354904)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.18
, pp. 2226-2232
-
-
Southam, L.1
Rodriguez-Lopez, J.2
Wilkins, J.M.3
Pombo-Suarez, M.4
Snelling, S.5
Gomez-Reino, J.J.6
Chapman, K.7
Gonzalez, A.8
Loughlin, J.9
-
24
-
-
0028126646
-
Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-b superfamily predominantly expressed in long bones during human embryonic development
-
1:CAS:528:DyaK2MXhtlWgurc%3D 7961761
-
SC Chang B Hoang JT Thomas S Vukicevic FP Luyten NJ Ryba CA Kozak AH Reddi M Moos 1994 Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-b superfamily predominantly expressed in long bones during human embryonic development J Biol Chem 269 28227 28234 1:CAS:528:DyaK2MXhtlWgurc%3D 7961761
-
(1994)
J Biol Chem
, vol.269
, pp. 28227-28234
-
-
Chang, S.C.1
Hoang, B.2
Thomas, J.T.3
Vukicevic, S.4
Luyten, F.P.5
Ryba, N.J.6
Kozak, C.A.7
Reddi, A.H.8
Moos, M.9
-
25
-
-
33845352083
-
Effects of growth differentiation factor-5 on the intervertebral disc - In vitro bovine study and in vivo rabbit disc degeneration model study
-
DOI 10.1097/01.brs.0000248428.22823.86, PII 0000763220061201000006
-
T Chujo S Anhoward K Akeda K Miyamoto C Muehleman M Attawia G Andersson K Masuda 2006 Effects of growth differentiation factor-5 on the intervertebral disc-in vitro bovine study and in vivo rabbit disc degeneration model study Spine 31 2909 2917 10.1097/01.brs.0000248428.22823.86 10.1097/01.brs.0000248428. 22823.86 17139221 (Pubitemid 44885707)
-
(2006)
Spine
, vol.31
, Issue.25
, pp. 2909-2917
-
-
Chujo, T.1
An, H.S.2
Akeda, K.3
Miyamoto, K.4
Muehleman, C.5
Attawia, M.6
Andersson, G.7
Masuda, K.8
-
26
-
-
31144438110
-
Functional diversity of plant-pollinator interaction webs enhances the persistence of plant communities
-
DOI 10.1371/journal.pbio.0040001, e1
-
BF Voight S Kudaravalli X Wen JK Pritchard 2006 A map of recent positive selection in the human genome PLoS Biol 4 1 12 10.1371/journal.pbio.0040001 10.1371/journal.pbio.0040001 (Pubitemid 43128324)
-
(2006)
PLoS Biology
, vol.4
, Issue.1
, pp. 0129-0135
-
-
Fontaine, C.1
Dajoz, I.2
Meriguet, J.3
Loreau, M.4
|