Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations

Pharmaceutical Research

Volumn 27, Issue 2, 2010, Pages 314-326

  Hawe, Andrea ^a   Filipe, Vasco ^a   Jiskoot, Wim ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Aggregation; Fluorescence; Fluorescent molecular rotors; Monoclonal antibodies; Size exclusion chromatography

Indexed keywords

ADALIMUMAB; ANS FLUORESCENT DYE; BIS ANS FLUORESCENT DYE; ETANERCEPT; FLUORESCENT DYE; FLUORESCENT MOLECULAR ROTOR CCVJ; FLUORESCENT MOLECULAR ROTOR DCVJ; IMMUNOGLOBULIN G; NILE RED FLUORESCENT DYE; POLYSORBATE 20; POLYSORBATE 80; RITUXIMAB; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FLUORESCENCE POLARIZATION; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN AGGREGATION; STEADY STATE; TEMPERATURE MEASUREMENT; ULTRAVIOLET RADIATION; VISCOSITY;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; FLUORESCENT DYES; HUMANS; IMMUNOGLOBULIN G; MOLECULAR PROBES; POLYSORBATES; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

EID: 77949274507     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-0020-2     Document Type: Article

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