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Volumn , Issue , 2007, Pages 53-80

Safety pharmacology and the GI tract

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EID: 77949271749     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter
Times cited : (4)

References (81)
  • 3
    • 85057501368 scopus 로고    scopus 로고
    • Safety pharmacology, pharmacokinetics and toxicology: An obstacle race in the development of a pharmaceutical compound
    • Guzmán, A., Safety pharmacology, pharmacokinetics and toxicology: an obstacle race in the development of a pharmaceutical compound. Meth. Findings Exp. Chem. Pharmacol., 25, Suppl. A, 2003.
    • (2003) Meth. Findings Exp. Chem. Pharmacol. , vol.25
    • Guzmán, A.1
  • 4
    • 0027933948 scopus 로고
    • Research overview status of safety pharmacology in the pharmaceutical industry, 1993
    • Kinter, L.B. et al., Research overview status of safety pharmacology in the pharmaceutical industry, 1993. Drug Develop. Res., 32, 208, 1994.
    • (1994) Drug Develop. Res. , vol.32 , pp. 208
    • Kinter, L.B.1
  • 5
    • 0029887456 scopus 로고    scopus 로고
    • A performance standard for clinical and functional observational battery examinations of rats
    • Mattsson, J.L., Spencer, P.J., and Albee, R.R., A performance standard for clinical and functional observational battery examinations of rats. J. Amer. Col. Toxicol., 15, 239, 1996.
    • (1996) J. Amer. Col. Toxicol. , vol.15 , pp. 239
    • Mattsson, J.L.1    Spencer, P.J.2    Albee, R.R.3
  • 6
    • 0014424692 scopus 로고
    • Comprehensive observational assessment: A systematic, quantitative procedure for assessing the behavioural and physiologic state of the mouse
    • Berlin
    • Irwin, S., Comprehensive observational assessment: a systematic, quantitative procedure for assessing the behavioural and physiologic state of the mouse. Psychopharmacologia (Berlin), 13, 222, 1968.
    • (1968) Psychopharmacologia , vol.13 , pp. 222
    • Irwin, S.1
  • 7
    • 0026324042 scopus 로고
    • Strategies for and experience with neurotoxicity testing of new pharmaceuticals
    • Haggerty, G.C., Strategies for and experience with neurotoxicity testing of new pharmaceuticals. J. Amer. Col. Toxicol., 10, 677, 1991.
    • (1991) J. Amer. Col. Toxicol. , vol.10 , pp. 677
    • Haggerty, G.C.1
  • 8
    • 0027990459 scopus 로고
    • Safety pharmacology of the respiratory system: Techniques and study design
    • Murphy, D.J., Safety pharmacology of the respiratory system: techniques and study design. Drug Develop. Res., 32, 237, 1994.
    • (1994) Drug Develop. Res. , vol.32 , pp. 237
    • Murphy, D.J.1
  • 10
    • 2542446138 scopus 로고    scopus 로고
    • Gastrointestinal tract models and techniques for use in safety pharmacology
    • Harrison, A.P. et al., Gastrointestinal tract models and techniques for use in safety pharmacology. J. Pharmacol. Toxicol. Meth., 49, 187, 2004.
    • (2004) J. Pharmacol. Toxicol. Meth. , vol.49 , pp. 187
    • Harrison, A.P.1
  • 11
    • 0010211259 scopus 로고    scopus 로고
    • Novel techniques for testing of esophageal irritancy of liquids and tablets in dogs
    • Smith, S. et al., Novel techniques for testing of esophageal irritancy of liquids and tablets in dogs. Contemp. Top. Lab. Anim. Sci., 37, 66, 1998.
    • (1998) Contemp. Top. Lab. Anim. Sci. , vol.37 , pp. 66
    • Smith, S.1
  • 12
    • 0031671019 scopus 로고    scopus 로고
    • Esophageal irritation due to alendronate sodium tablets: Possible mechanisms
    • Peter, C.P., Handt, L.K., and Smith, S.M. Esophageal irritation due to alendronate sodium tablets: possible mechanisms. Dig. Dis. Sci., 43, 1998, 1998.
    • (1998) Dig. Dis. Sci. , vol.43 , pp. 1998
    • Peter, C.P.1    Handt, L.K.2    Smith, S.M.3
  • 13
    • 0034001086 scopus 로고    scopus 로고
    • Upper gastrointestinal toxicity of alendronate
    • Lowe, C.E. et al., Upper gastrointestinal toxicity of alendronate. Am. J. Gastroenterol., 95, 634. 2000.
    • (2000) Am. J. Gastroenterol. , vol.95 , pp. 634
    • Lowe, C.E.1
  • 14
    • 0022347594 scopus 로고
    • What’s new in steroid and nonsteroid drug effects on gastroduodenal mucosa?
    • Borsch, G. and Schmidt, G., What’s new in steroid and nonsteroid drug effects on gastroduodenal mucosa? Pathol. Res. Pract., 180, 437, 1985.
    • (1985) Pathol. Res. Pract. , vol.180 , pp. 437
    • Borsch, G.1    Schmidt, G.2
  • 15
    • 0001693983 scopus 로고
    • Histopathology of steroid-induced ulcers: An experimental study in the rat
    • Robert, A. and Nezamis, J.E., Histopathology of steroid-induced ulcers: an experimental study in the rat. Arch. Pathol., 77, 407, 1964.
    • (1964) Arch. Pathol. , vol.77 , pp. 407
    • Robert, A.1    Nezamis, J.E.2
  • 16
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane, J.R., Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol., 231, 232, 1971.
    • (1971) Nat. New Biol. , vol.231 , pp. 232
    • Vane, J.R.1
  • 17
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Vane, J.R. and Botting, R.M., The mechanism of action of aspirin. Thromb. Res. 15, 255, 2003.
    • (2003) Thromb. Res. , vol.15 , pp. 255
    • Vane, J.R.1    Botting, R.M.2
  • 18
    • 0019351569 scopus 로고
    • Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat
    • Whittle, B.J., Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology, 80, 94, 1981.
    • (1981) Gastroenterology , vol.80 , pp. 94
    • Whittle, B.J.1
  • 19
    • 0036827832 scopus 로고    scopus 로고
    • Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis
    • Kato, S. et al., Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis. J. Pharmacol. Exp. Ther., 303, 503, 2002.
    • (2002) J. Pharmacol. Exp. Ther. , vol.303 , pp. 503
    • Kato, S.1
  • 20
    • 0033657162 scopus 로고    scopus 로고
    • Gastrointestinal damage induced by celecoxib and rofecoxib in rats
    • Laudanno, O.M. et al., Gastrointestinal damage induced by celecoxib and rofecoxib in rats. Acta Gastroenterol. Latinoam., 30, 27, 2000.
    • (2000) Acta Gastroenterol. Latinoam. , vol.30 , pp. 27
    • Laudanno, O.M.1
  • 21
    • 0031007566 scopus 로고    scopus 로고
    • Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats
    • Takeuchi, K. et al., Analysis of pathogenic elements involved in gastric lesions induced by non-steroidal anti-inflammatory drugs in rats. J. Gastroenterol. Hepatol. 12, 36. 1997.
    • (1997) J. Gastroenterol. Hepatol. , vol.12 , pp. 36
    • Takeuchi, K.1
  • 22
    • 0033772994 scopus 로고    scopus 로고
    • Relationship between ethanol-induced gastritis and gastric ulcer formation in rats
    • Liu, E.S. and Cho, C.H., Relationship between ethanol-induced gastritis and gastric ulcer formation in rats. Digestion, 62, 232, 2000.
    • (2000) Digestion , vol.62 , pp. 232
    • Liu, E.S.1    Cho, C.H.2
  • 23
    • 0023191442 scopus 로고
    • Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats
    • Suwa, T. et al., Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats. Agents Actions, 21, 167, 1987.
    • (1987) Agents Actions , vol.21 , pp. 167
    • Suwa, T.1
  • 24
    • 14644408717 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and the small intestine
    • Fortun, P.J. and Hawkey, C.J., Nonsteroidal anti-inflammatory drugs and the small intestine. Curr. Opin. Gastroenterol., 21, 169, 2005.
    • (2005) Curr. Opin. Gastroenterol. , vol.21 , pp. 169
    • Fortun, P.J.1    Hawkey, C.J.2
  • 25
    • 0023278210 scopus 로고
    • Mechanisms of mucosal injury in the stomach and duodenum: Timesequence analysis of morphologic, functional, biochemical and histochemical studies
    • Szabo, S., Mechanisms of mucosal injury in the stomach and duodenum: timesequence analysis of morphologic, functional, biochemical and histochemical studies. Scand. J. Gastroenterol. Suppl. 127, 2. 1987.
    • (1987) Scand. J. Gastroenterol. Suppl. , vol.127 , pp. 2
    • Szabo, S.1
  • 26
    • 0014938390 scopus 로고
    • Aspirin: Intestinal damage in rats
    • Brodie, D.A., Tate, C.L., and Hooke, K.F., Aspirin: intestinal damage in rats. Science, 9, 183, 1970.
    • (1970) Science , vol.9 , pp. 183
    • Brodie, D.A.1    Tate, C.L.2    Hooke, K.F.3
  • 27
    • 0016682150 scopus 로고
    • Factors influencing the indomethacin-induced intestinal lesions in the rat
    • Mariani, L., Factors influencing the indomethacin-induced intestinal lesions in the rat. Eur. J. Toxicol. Environ. Hyg., 8, 335, 1975.
    • (1975) Eur. J. Toxicol. Environ. Hyg. , vol.8 , pp. 335
    • Mariani, L.1
  • 28
    • 0014877725 scopus 로고
    • Indomethacin-induced intestinal lesions in the rat
    • Brodie, D.A. et al., Indomethacin-induced intestinal lesions in the rat. Toxicol. Appl. Pharmacol., 17, 615, 1970.
    • (1970) Toxicol. Appl. Pharmacol. , vol.17 , pp. 615
    • Brodie, D.A.1
  • 29
    • 0023882811 scopus 로고
    • Assessment and validation of animal models to evaluate topical effects of substances on gastrointestinal mucosa
    • Fara, J.W. et al., Assessment and validation of animal models to evaluate topical effects of substances on gastrointestinal mucosa. Pharm. Res. 5, 165, 1988.
    • (1988) Pharm. Res. , vol.5 , pp. 165
    • Fara, J.W.1
  • 30
    • 0036968217 scopus 로고    scopus 로고
    • Serotonergic modulating drugs for functional gastrointestinal diseases
    • Spiller, R., Serotonergic modulating drugs for functional gastrointestinal diseases. Br. J. Clin. Pharmacol., 54, 11, 2002.
    • (2002) Br. J. Clin. Pharmacol. , vol.54 , pp. 11
    • Spiller, R.1
  • 31
    • 0035124740 scopus 로고    scopus 로고
    • Ischemic colitis during treatment with alosetron
    • Friedel, D., Thomas, R., and Fisher, R.S., Ischemic colitis during treatment with alosetron. Gastroenterology, 120, 557, 2001.
    • (2001) Gastroenterology , vol.120 , pp. 557
    • Friedel, D.1    Thomas, R.2    Fisher, R.S.3
  • 32
    • 0036189032 scopus 로고    scopus 로고
    • The complexity of drug development for irritable bowel syndrome
    • Kamm, M.A., The complexity of drug development for irritable bowel syndrome. Aliment. Pharmacol. Ther., 16, 343, 2002.
    • (2002) Aliment. Pharmacol. Ther. , vol.16 , pp. 343
    • Kamm, M.A.1
  • 33
    • 0037169205 scopus 로고    scopus 로고
    • Involvement of central K(ATP) channels in the gastric antisecretory action of 2-adrenoceptor agonists and beta-endorphin in rats
    • Mullner, K. et al., Involvement of central K(ATP) channels in the gastric antisecretory action of 2-adrenoceptor agonists and beta-endorphin in rats. Eur. J. Pharmacol., 435, 225, 2002.
    • (2002) Eur. J. Pharmacol. , vol.435 , pp. 225
    • Mullner, K.1
  • 34
    • 0021891914 scopus 로고
    • Effect of 2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats
    • Kunchandy, J., Khanna. S., and Kulkarni, S.K., Effect of 2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats. Arch. Int. Pharmacodyn. Ther., 275, 123, 1985.
    • (1985) Arch. Int. Pharmacodyn. Ther. , vol.275 , pp. 123
    • Kunchandy, J.1    Khanna, S.2    Kulkarni, S.K.3
  • 35
    • 0013913736 scopus 로고
    • The mechanism of the inhibition of gastric secretion produced by esophageal ligation in the pylorus-ligated rat
    • Brodie, D.A. and Knapp, P.G., The mechanism of the inhibition of gastric secretion produced by esophageal ligation in the pylorus-ligated rat. Gastroenterology, 50, 787, 1966.
    • (1966) Gastroenterology , vol.50 , pp. 787
    • Brodie, D.A.1    Knapp, P.G.2
  • 37
    • 0018380407 scopus 로고
    • Antisecretory actions of aminophylline in the rat and dog
    • Jacoby, H.I. et al., Antisecretory actions of aminophylline in the rat and dog. Digestion, 19, 237, 1979.
    • (1979) Digestion , vol.19 , pp. 237
    • Jacoby, H.I.1
  • 38
    • 0014470662 scopus 로고
    • Gastric emptying in rats with chronic gastric fistulas
    • Setler, P.E. and Smith, G.P., Gastric emptying in rats with chronic gastric fistulas. Am. J. Dig. Dis., 14, 137, 1969.
    • (1969) Am. J. Dig. Dis. , vol.14 , pp. 137
    • Setler, P.E.1    Smith, G.P.2
  • 39
    • 0242403409 scopus 로고    scopus 로고
    • Sildenafil, a phosphodiesterase-5 inhibitor, delays gastric emptying and gastrointestinal transit of liquid in awake rats
    • de Rosalmeida, M.C. et al., Sildenafil, a phosphodiesterase-5 inhibitor, delays gastric emptying and gastrointestinal transit of liquid in awake rats. Dig. Dis. Sci., 48, 2064, 2003.
    • (2003) Dig. Dis. Sci. , vol.48 , pp. 2064
    • de Rosalmeida, M.C.1
  • 40
    • 2542438864 scopus 로고    scopus 로고
    • Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: A study of CCK-A, B, and AB receptor gene knockout mice
    • Miyasaka, K. et al., Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A, B, and AB receptor gene knockout mice. J. Gastroenterol., 39, 319, 2004.
    • (2004) J. Gastroenterol. , vol.39 , pp. 319
    • Miyasaka, K.1
  • 41
    • 0017660655 scopus 로고
    • Effect of anti-Parkinsonism drugs on gastric emptying and intestinal transit in the rat
    • Feldman, S. and Putcha, L., Effect of anti-Parkinsonism drugs on gastric emptying and intestinal transit in the rat. Pharmacology, 15, 503, 1977.
    • (1977) Pharmacology , vol.15 , pp. 503
    • Feldman, S.1    Putcha, L.2
  • 42
    • 0022506761 scopus 로고
    • A new simple mouse model for the in vivo evaluation of cholecystokinin (CCK) antagonists: Comparative potencies and durations of action of nonpeptide antagonists
    • Lotti, V.J. et al., A new simple mouse model for the in vivo evaluation of cholecystokinin (CCK) antagonists: comparative potencies and durations of action of nonpeptide antagonists. Life Sci., 39, 1631, 1986.
    • (1986) Life Sci. , vol.39 , pp. 1631
    • Lotti, V.J.1
  • 43
    • 1042265028 scopus 로고    scopus 로고
    • Influence of simulated weightlessness on the pharmacokinetics of acetaminophen administered by the oral route: A study in the rat
    • Gandia, P. et al., Influence of simulated weightlessness on the pharmacokinetics of acetaminophen administered by the oral route: a study in the rat. Fundam. Clin. Pharmacol., 18, 57, 2004.
    • (2004) Fundam. Clin. Pharmacol. , vol.18 , pp. 57
    • Gandia, P.1
  • 44
    • 11344293886 scopus 로고    scopus 로고
    • Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats
    • Pu, H.F. et al., Effects of juice from Morinda citrifolia (Noni) on gastric emptying in male rats. Chin. J. Physiol., 47, 169, 2004.
    • (2004) Chin. J. Physiol. , vol.47 , pp. 169
    • Pu, H.F.1
  • 45
    • 0013866158 scopus 로고
    • A comparison of anticholinergic drugs on gastric secretion, gastric emptying, and pupil diameter in the rat
    • Brodie, D.A., A comparison of anticholinergic drugs on gastric secretion, gastric emptying, and pupil diameter in the rat. Gastroenterology, 50, 45, 1966.
    • (1966) Gastroenterology , vol.50 , pp. 45
    • Brodie, D.A.1
  • 46
    • 0014076676 scopus 로고
    • Gastrointestinal actions of metoclopramide: An experimental study
    • Jacoby, H.I. and Brodie, D.A., Gastrointestinal actions of metoclopramide: an experimental study. Gastroenterology, 52, 676, 1967.
    • (1967) Gastroenterology , vol.52 , pp. 676
    • Jacoby, H.I.1    Brodie, D.A.2
  • 47
    • 2942737284 scopus 로고    scopus 로고
    • A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat
    • Tabosa, A. et al., A comparative study of the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat. Dig. Dis. Sci., 49, 602, 2004.
    • (2004) Dig. Dis. Sci. , vol.49 , pp. 602
    • Tabosa, A.1
  • 48
    • 0030917885 scopus 로고    scopus 로고
    • Effects of gastroprokinetic agents on gastroparesis in streptozotocin- induced diabetic rats
    • Yamano, M. et al., Effects of gastroprokinetic agents on gastroparesis in streptozotocin- induced diabetic rats. Naun. Schmied. Arch. Pharmacol., 356, 145, 1997.
    • (1997) Naun. Schmied. Arch. Pharmacol. , vol.356 , pp. 145
    • Yamano, M.1
  • 49
    • 0030882044 scopus 로고    scopus 로고
    • Clonidine inhibits gastric motility in the rat
    • Asai, T., Vickers, M.D., and Power, I., Clonidine inhibits gastric motility in the rat. Europ. J. Anaesth., 14, 316, 1997.
    • (1997) Europ. J. Anaesth. , vol.14 , pp. 316
    • Asai, T.1    Vickers, M.D.2    Power, I.3
  • 50
    • 0036131164 scopus 로고    scopus 로고
    • Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood ethanol elevation in rats: Involvement of inhibition of gastric emptying and increase in gastric juice secretion
    • Matsuda, H. et al., Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion. Alcohol Alcoholism, 37, 121, 2002.
    • (2002) Alcohol Alcoholism , vol.37 , pp. 121
    • Matsuda, H.1
  • 51
    • 0001357956 scopus 로고
    • Two new methods for pharmacological comparison of insoluble purgatives
    • Macht, D.I., and Barba-Gose, J., Two new methods for pharmacological comparison of insoluble purgatives. J. Am. Pharm. Assoc. 20, 558, 1931.
    • (1931) J. Am. Pharm. Assoc. , vol.20 , pp. 558
    • Macht, D.I.1    Barba-Gose, J.2
  • 52
    • 0242334080 scopus 로고    scopus 로고
    • Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice
    • Tan-No, K. et al., Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice. Eur. J. Pharm. Sci., 20, 357, 2003.
    • (2003) Eur. J. Pharm. Sci. , vol.20 , pp. 357
    • Tan-No, K.1
  • 53
    • 0030974959 scopus 로고    scopus 로고
    • Effect of GK-128 [2-[(2-methylimidazol-1-yl)methyl]-benzo[f]thiochromen-1-one monohydrochloride hemihydrate], a selective 5-hydroxytryptamine3 receptor antagonist, on colonic function in rats
    • Ito, C. et al., Effect of GK-128 [2-[(2-methylimidazol-1-yl)methyl]-benzo[f]thiochromen-1-one monohydrochloride hemihydrate], a selective 5-hydroxytryptamine3 receptor antagonist, on colonic function in rats. J. Pharmacol. Exp. Ther., 280, 67, 1997.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 67
    • Ito, C.1
  • 54
    • 0026524794 scopus 로고
    • Stimulation of faecal excretion in rats by 2-adrenergic antagonists
    • Croci, T. and Bianchetti, A., Stimulation of faecal excretion in rats by 2-adrenergic antagonists. J. Pharm. Pharmacol., 44, 358, 1992.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 358
    • Croci, T.1    Bianchetti, A.2
  • 55
    • 0016765341 scopus 로고
    • The antidiarrheal action of bismuth subsalicylate in the mouse and the rat
    • Goldenberg, M.M., Honkomp, L.J., and Castellion, A.W., The antidiarrheal action of bismuth subsalicylate in the mouse and the rat. Am. J. Dig. Dis., 20, 955, 1975.
    • (1975) Am. J. Dig. Dis. , vol.20 , pp. 955
    • Goldenberg, M.M.1    Honkomp, L.J.2    Castellion, A.W.3
  • 56
    • 0016840588 scopus 로고
    • Loperamide antagonism of castor oil-induced diarrhea in rats:A quantitative study
    • Awouters, F. et al., Loperamide antagonism of castor oil-induced diarrhea in rats:a quantitative study. Arch. Int. Pharmacodyn. Ther., 217, 29, 1975.
    • (1975) Arch. Int. Pharmacodyn. Ther. , vol.217 , pp. 29
    • Awouters, F.1
  • 57
    • 0025924590 scopus 로고
    • Prostaglandin E2-induced diarrhea in mice: Importance of colonic secretion
    • Riviere, P.J. et al., Prostaglandin E2-induced diarrhea in mice: importance of colonic secretion. Pharmacol. Exp. Ther., 256, 547, 1991.
    • (1991) Pharmacol. Exp. Ther. , vol.256 , pp. 547
    • Riviere, P.J.1
  • 58
    • 0009706406 scopus 로고
    • Method for the evaluation of colonic propulsive motility in the mouse after ICV administered compounds
    • Jacoby, H.I. and Lopez, I.A., Method for the evaluation of colonic propulsive motility in the mouse after ICV administered compounds. Dig. Dis. Sci. 29, 551, 1984.
    • (1984) Dig. Dis. Sci. , vol.29 , pp. 551
    • Jacoby, H.I.1    Lopez, I.A.2
  • 59
    • 0023582964 scopus 로고
    • Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of µ- and -opioid agonists
    • Raffa, R.B., Mathiasen, J.R, and Jacoby, H.I., Colonic bead expulsion time in normal and mu-opioid receptor deficient (CXBK) mice following central (ICV) administration of µ- and -opioid agonists. Life Sci., 41, 2229, 1987.
    • (1987) Life Sci. , vol.41 , pp. 2229
    • Raffa, R.B.1    Mathiasen, J.R.2    Jacoby, H.I.3
  • 60
    • 0025959453 scopus 로고
    • Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility
    • Jacoby, H.I., Bonfilio, A.C. and Raffa, R.B., Central and peripheral administration of serotonin produces opposite effects on mouse colonic propulsive motility. Neurosci. Lett., 122, 122, 1991.
    • (1991) Neurosci. Lett. , vol.122 , pp. 122
    • Jacoby, H.I.1    Bonfilio, A.C.2    Raffa, R.B.3
  • 61
    • 0025034261 scopus 로고
    • Effect of the Phe-D-Met-Arg-Phe-NH2-related peptides on mouse colonic propulsive motility: A structure-activity relationship study
    • Raffa, R.B. and Jacoby, H.I., Effect of the Phe-D-Met-Arg-Phe-NH2-related peptides on mouse colonic propulsive motility: a structure-activity relationship study. J. Pharm. Exp. Ther. 254, 809, 1990.
    • (1990) J. Pharm. Exp. Ther. , vol.254 , pp. 809
    • Raffa, R.B.1    Jacoby, H.I.2
  • 62
    • 0032707760 scopus 로고    scopus 로고
    • Effects of antisense oligonucleotides on brain delta-opioid receptor density and on SNC80-induced locomotor stimulation and colonic transit inhibition in rats
    • Negri, L. et al., Effects of antisense oligonucleotides on brain delta-opioid receptor density and on SNC80-induced locomotor stimulation and colonic transit inhibition in rats. Br. J. Pharmacol., 128, 1554, 1999.
    • (1999) Br. J. Pharmacol. , vol.128 , pp. 1554
    • Negri, L.1
  • 63
    • 1942453392 scopus 로고    scopus 로고
    • Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice
    • Martínez, V. et al., Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice. J. Physiol., 556, 221, 2004.
    • (2004) J. Physiol. , vol.556 , pp. 221
    • Martínez, V.1
  • 64
    • 0037199901 scopus 로고    scopus 로고
    • Single millimeter wave treatment does not impair gastrointestinal transit in mice
    • Radzievsky, A.A. et al., Single millimeter wave treatment does not impair gastrointestinal transit in mice. Life Sci., 71, 1763, 2002.
    • (2002) Life Sci. , vol.71 , pp. 1763
    • Radzievsky, A.A.1
  • 66
    • 0027318922 scopus 로고
    • Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion
    • Yamada, K. and Onoda, Y., Comparison of the effects of T-1815, yohimbine and naloxone on mouse colonic propulsion. J. Smooth Muscle Res. 29, 47, 1993.
    • (1993) J. Smooth Muscle Res. , vol.29 , pp. 47
    • Yamada, K.1    Onoda, Y.2
  • 67
    • 0025236582 scopus 로고
    • Animal models in the study of vomiting
    • King, G.L., Animal models in the study of vomiting. Can. J. Physiol. Pharmacol., 68, 260, 1990.
    • (1990) Can. J. Physiol. Pharmacol. , vol.68 , pp. 260
    • King, G.L.1
  • 68
    • 85057440416 scopus 로고
    • Absence of emetic effects of morphine and loperamide in Suncus murinus
    • Selve, N. et al., Absence of emetic effects of morphine and loperamide in Suncus murinus. Eur. J. Pharmacol. 2, 256, 1994.
    • (1994) Eur. J. Pharmacol. , vol.2 , pp. 256
    • Selve, N.1
  • 69
    • 0030321537 scopus 로고    scopus 로고
    • Chemotherapy-induced nausea and vomiting: From experimentation to experience
    • Marty, M., Chemotherapy-induced nausea and vomiting: from experimentation to experience. Bull. Cancer, 83,1014, 1996.
    • (1996) Bull. Cancer , vol.83 , pp. 1014
    • Marty, M.1
  • 70
    • 0029788231 scopus 로고    scopus 로고
    • Mechanisms of chemotherapy/radiotherapy-induced emesis in animal models
    • Naylor, R.J. and Rudd, J.A., Mechanisms of chemotherapy/radiotherapy-induced emesis in animal models. Oncology, 53, Suppl. 1, 8, 1996.
    • (1996) Oncology , vol.53 , pp. 8
    • Naylor, R.J.1    Rudd, J.A.2
  • 71
    • 0033813259 scopus 로고    scopus 로고
    • Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: Implications for phase I study design
    • Kinsella, T.J. et al., Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design. Clin. Cancer. Res., 6, 3670, 2000.
    • (2000) Clin. Cancer. Res. , vol.6 , pp. 3670
    • Kinsella, T.J.1
  • 72
    • 0017709109 scopus 로고
    • Long term bile collection in the rat
    • Enderlin, F.E. and Honohan, T., Long term bile collection in the rat. Lab. Anim. Sci., 27, 490, 1977.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 490
    • Enderlin, F.E.1    Honohan, T.2
  • 73
    • 0017640694 scopus 로고
    • A technique for chronic intermittent bile collection from the rat
    • Chipman, J.K. and Cropper, N.C., A technique for chronic intermittent bile collection from the rat. Res. Vet. Sci., 22, 366, 1977.
    • (1977) Res. Vet. Sci. , vol.22 , pp. 366
    • Chipman, J.K.1    Cropper, N.C.2
  • 74
    • 0017615836 scopus 로고
    • Methodology for the determination of bioavailability of labeled residues
    • Gallo-Torres, H.E., Methodology for the determination of bioavailability of labeled residues. J. Toxicol. Environ. Health, 2, 827, 1977.
    • (1977) J. Toxicol. Environ. Health , vol.2 , pp. 827
    • Gallo-Torres, H.E.1
  • 75
    • 0019720705 scopus 로고
    • Bile collection in free moving rats
    • Balabaud, C. et al., Bile collection in free moving rats. Lab. Anim. Sci. 31, 273, 1981.
    • (1981) Lab. Anim. Sci. , vol.31 , pp. 273
    • Balabaud, C.1
  • 76
    • 0019807228 scopus 로고
    • A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat
    • Tomlinson, P.W., Jeffery, D.J., and Filer, C.W., A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat. Xenobiotica, 11, 863, 1981.
    • (1981) Xenobiotica , vol.11 , pp. 863
    • Tomlinson, P.W.1    Jeffery, D.J.2    Filer, C.W.3
  • 77
    • 0024523225 scopus 로고
    • A new method of bile duct cannulation allowing bile collection and re-infusion in the conscious rat
    • Rath, L. and Hutchison, M., A new method of bile duct cannulation allowing bile collection and re-infusion in the conscious rat. Lab. Anim., 23, 163, 1989.
    • (1989) Lab. Anim. , vol.23 , pp. 163
    • Rath, L.1    Hutchison, M.2
  • 78
    • 0026769452 scopus 로고
    • Improved method for bile collection in unrestrained conscious rats
    • Heitmeyer, S.A. and Powers, J.F., Improved method for bile collection in unrestrained conscious rats. Lab. Anim. Sci., 42, 312, 1992.
    • (1992) Lab. Anim. Sci. , vol.42 , pp. 312
    • Heitmeyer, S.A.1    Powers, J.F.2
  • 79
    • 0016720944 scopus 로고
    • Action of intragastric ethanol on the pancreatic secretion of conscious rats
    • Cavarzan, A. et al., Action of intragastric ethanol on the pancreatic secretion of conscious rats. Digestion, 13, 145, 1975.
    • (1975) Digestion , vol.13 , pp. 145
    • Cavarzan, A.1
  • 80
    • 33744596269 scopus 로고
    • Collection of pancreatic juice from rats and consequences of its continued loss
    • Colwell, A.R. Jr., Collection of pancreatic juice from rats and consequences of its continued loss. Am. J. Physiol., 164, 812, 1951.
    • (1951) Am. J. Physiol. , vol.164 , pp. 812
    • Colwell, A.R.1
  • 81
    • 0020080301 scopus 로고
    • Inhibition of gastric and pancreatic secretions by cerebroventricular injections of gastrin-releasing peptide and bombesin in rats
    • Roze, C., Ling, N. and Florencio, H., Inhibition of gastric and pancreatic secretions by cerebroventricular injections of gastrin-releasing peptide and bombesin in rats. Regul. Pept., 3, 105, 1982.
    • (1982) Regul. Pept. , vol.3 , pp. 105
    • Roze, C.1    Ling, N.2    Florencio, H.3


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