Effect of GK-128 [2-[(2-methylimidazol-1-yl)methyl]- benzo[f]thiochromen-1-one monohydrochloride hemihydrate], a selective 5- hydroxytryptamine3 receptor antagonist, on colonic function in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 67-72

  Ito, Chika ^a   Isobe, Yoshihiko ^a   Kawamura, Reiko ^a   Kiuchi, Yoichi ^a   Tsuchida, Katsuharu ^a   Higuchi, Shohei ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 2 [(2 METHYL 1 IMIDAZOLYL)METHYL]BENZO[F]THIOCHROMEN 1 ONE; 2 METHYLSEROTONIN; ATROPINE; AZASETRON; DIAZEPAM; GRANISETRON; ONDANSETRON; RAMOSETRON; SEROTONIN; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COLON; CONTROLLED STUDY; DEFECATION; DOSE RESPONSE; FECES; INTESTINE FUNCTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CHROMONES; COLON; DEFECATION; IMIDAZOLES; MALE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030974959     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. 3 receptor in vitro and in vivo. Eur. J. Pharmacol. 237: 299-309, 1993.
2. 3 receptor antagonists in modulation of visceral hypersensitivity. Br. J. Pharmacol. 114: 558-562, 1995.
3. BEARCROFT, C. P., PERRETT, D. AND FARTHING, M. J. G.: Post-prandial plasma 5-hydroxytryptamine is increased in diarrhoea-predominant irritable bowel syndrome. Gastroenterology 106: A465, 1994.
4. 3H]RS-42358-197: Evidence for receptor heterogeneity. J. Neurochem. 61: 1927-1932, 1993.
5. 3 receptors in three isolated preparations derived from guinea-pig tissues. Br. J. Pharmacol. 101: 591-598, 1990.
6. 4 receptors in vitro. J. Auton. Pharmacol. 12: 321-333, 1992.
7. ENCK, P., MERLIN, V., ERCKENBRECHT, J. F. AND WIENBECK, M.: Stress effects on gastrointestinal transit in the rat. Gut 30: 455-459, 1989.
8. 4 receptors of the release of 5-hydroxytryptamine from guinea-pig small intestine. Naunyn-Schmiedebergs Arch. Pharmacol. 347: 137-140, 1993.
9. 3 receptors in stress-induced colonic motor alterations in rats. Eur. J. Pharmacol. 233: 193-199, 1993.
10. 3 receptor antagonist. Jpn. J. Pharmacol. 61: 198P, 1993.
11. ITO, C., ISOBE, Y., KIJIMA, H., KIUCHI, Y., OHTSUKI, H., KAWAMURA, R., TSUCHIDA, K. AND HIGUCHI, S.: The anti-emetic activity of GK-128 in Suncus murinus. Eur. J. Pharmacol. 285: 37-43, 1995.
12. 4 receptor dual antagonist, on colonic function in vivo. J Pharmacol. Exp. Ther. 266: 74-80, 1993.
13. 3 receptors. Med. Res. Rev. 10: 441-475, 1990a.
14. 3 receptor agonist. Eur. J. Pharmacol. 182: 193-197, 1990b.
15. 3 receptor antagonists. Drugs Future 14: 875-889, 1989.
16. 3 receptor antagonist, in rats: Inhibition of distal colonic function. Jpn. J. Pharmacol. 63: 495-502, 1993.
17. 3 antagonist in irritable bowel syndrome (IBS). Gastroenterology 100: A468, 1991.
18. 3 receptor antagonist, and its enantiomer in the isolated tissue. J. Pharmacol. Exp. Ther. 259: 15-21, 1991.
19. 3 receptor in stress-induced defecation. J. Pharmacol. Exp. Ther. 261: 297-303, 1992.
20. NARDUCCI, F., SNAPE, W. J., BATTLE, W. M., RONDON, R. L. AND COHEN, S.: Increased colonic motility during exposure to a stressful situation. Dig. Dis. Sci. 30: 40-44, 1985.
21. 3-receptor antagonist, in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 7: 175-180, 1993.
22. READ, N. W. AND GWEE, K. A.: The importance of 5-hydroxytryptamine receptors in the gut. Pharmacol. Ther. 62: 159-173, 1994.
23. 3 receptor-antagonism: Evidence for heterogenous efficacy among different antagonists in guinea-pigs. J. Pharm. Pharmacol. 46: 666-670, 1994.
24. 3 receptor-antagonists. In Serotonin: Molecular Biology, Receptors and Functional Effects, ed. by J. R. Fozard and P. R. Saxena, pp. 381-388, Birkhauser-Verlag, Basel, 1991.
25. 3 receptors. Jpn. J. Pharmacol. 59: 443-448, 1992.
26. 3 receptor antagonist (ICS 205-930) on colonic motor activity in healthy men. Br. J. Clin. Pharmacol. 28: 315-322, 1989.
27. 3) receptor antagonist, ondansetron (GR38032F), in diarrhea predominant irritable bowel syndrome (IBS). Gastroenterology 98: A394, 1990.
28. THOMPSON, W. C.: Progress report: The irritable bowel. Gut 25: 305-320, 1984.
29. 3 antagonist. Eur. J. Cancer 26: S12-S14, 1990.
30. WILLIAMS, C. L., VILLAR, R. G., PETERSON, J. M. AND BURKS, T. F.: Stress-induced changes in intestinal transit in the rat: A model for irritable bowel syndrome. Gastroenterology 94: 611-621, 1988.
31. 3H]RS-42368-197. J. Neurochem. 60: 921-930, 1993a.
32. 3H]granisetron. Neuropharmacology 32: 869-875, 1993b.