Exercise in the management of patients with chronic heart failure

Current Heart Failure Reports

Volumn 7, Issue 1, 2010, Pages 35-41

  Keteyian, Steven J ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Clinical events; Exercise; Heart failure; Physiology; Safety

Indexed keywords

AEROBIC EXERCISE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; ENDURANCE; EXERCISE; EXERCISE TOLERANCE; HEALTH STATUS; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART OUTPUT; HEART RATE; HOSPITALIZATION; HUMAN; MORTALITY; MUSCLE STRENGTH; OXYGEN CONSUMPTION; PATIENT ATTITUDE; PATIENT SAFETY; PRESERVED HEART LEFT VENTRICLE SYSTOLIC FUNCTION; QUALITY OF LIFE; REVIEW; RISK REDUCTION; SYMPATHETIC TONE; TREATMENT INDICATION;

CHRONIC DISEASE; EXERCISE; HEART FAILURE; HUMANS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 77949265933     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-010-0002-z     Document Type: Review

References (50)

1. AP Lee R Ice R Blessey ME Sanmarco 1979 Long-term effects of physical training on coronary patients with impaired ventricular function Circulation 60 1519 1526 1:STN:280:DyaL3c%2FksFenuw%3D%3D 115617
2. EH Conn RS Williams AG Wallace 1982 Exercise responses before and after physical conditioning in patients with severely depressed left ventricular function Am J Cardiol 49 296 300 10.1016/0002-9149(82)90504-5 1:STN:280:DyaL387jt1Cqug%3D%3D 7058745
3. MJ Sullivan MB Higginbotham FR Cobb 1988 Exercise training in patients with severe left ventricular dysfunction: hemodynamic and metabolic effects Circulation 78 506 515 1:STN:280:DyaL1czhtFChtQ%3D%3D 3409495
4. AJS Coats S Adamopoulos A Radaelli, et al. 1992 Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function Circulation 85 2119 2131 1:STN:280:DyaK383nsVGnsw%3D%3D 1591831
5. R Belardinelli D Georgiou V Scocco, et al. 1995 Low intensity exercise training in patients with chronic heart failure J Am Coll Cardiol 26 975 982 10.1016/0735-1097(95)00267-1 1:STN:280:DyaK28%2FgslensA%3D%3D 7560627
6. R Hambrecht J Niebauer E Fiehn, et al. 1995 Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles J Am Coll Cardiol 25 1239 1249 10.1016/0735-1097(94)00568-B 1:STN:280:DyaK2M3jvVOnsQ%3D%3D 7722116
7. SJ Keteyian AB Levine CA Brawner, et al. 1996 Exercise training in patients with heart failure. A randomized controlled trial Ann Intern Med 124 1051 1057 1:STN:280:DyaK283jtlCisQ%3D%3D 8633818
8. R Belardinelli D Georgious G Cianci A Purcaro 1999 Randomized, controlled trial of long-term moderate exercise training in chronic heart failure effects on functional capacity, quality of life, and clinical outcome Circulation 99 1173 1182 1:STN:280:DyaK1M7mvFSnsA%3D%3D 10069785
9. Piepoli MF, Davos C, Francis DP, Coats AJ: ExTraMATCH collaborative. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 2004, 328:189-196.
10. N Smart H Marwick 2004 Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity Am J Med 116 693 706 10.1016/j.amjmed.2003.11.033 15121496 (Pubitemid 38581115)
11. DJ Whellan CM O'Connor KL Lee, et al. 2007 HF-ACTION Trial Investigators. Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale Am Heart J 153 201 211 10.1016/j.ahj.2006.11.007 17239677 (Pubitemid 46096868)
12. SJ Keteyian CRC Marks CA Brawner, et al. 1996 Responses to arm exercise in patients with compensated heart failure J Cardiopulmonary Rehabil 16 366 371 10.1097/00008483-199611000-00005 1:STN:280:DyaK2s7jvVyisg%3D%3D (Pubitemid 27009642)
13. DW Kitzman WC Little PH Brubaker 2002 Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure JAMA 288 2144 2150 10.1001/jama.288.17.2144 12413374 (Pubitemid 35265382)
14. JR Wilson JL Martin D Schwartz N Ferraro 1984 Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle Circulation 69 1079 1087 1:STN:280:DyaL2c7otV2msQ%3D%3D 6713612
15. D Mancini G Walter N Reicheck, et al. 1992 Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure Circulation 85 1364 1373 1:CAS:528:DyaK38XisFehu78%3D 1555280
16. V Adams H Jiang J Yu, et al. 1999 Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance J Am Coll Cardiol 33 959 965 10.1016/S0735-1097(98)00626-3 1:STN:280: DyaK1M7ptVansQ%3D%3D 10091822
17. BD Duscha WE Kraus SJ Keteyian, et al. 1999 Capillary density of skeletal muscle a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations J Am Coll Cardiol 33 1956 1963 10.1016/S0735-1097(99)00101-1 1:STN:280: DyaK1M3ovFSntw%3D%3D 10362199
18. M Piepoli A Kaczmerik D Francis, et al. 2006 Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure Circulation 114 126 134 10.1161/CIRCULATIONAHA.105.605980 16818813 (Pubitemid 44420744)
19. TP Olson EM Snyder BD Johnson 2006 Exercise-disordered breathing in chronic heart failure Exerc Sport Sci Rev 34 194 201 10.1249/01.jes.0000240022. 30373.a2 17031258 (Pubitemid 44562944)
20. P Giannuzzi PL Temporelli U Corra, et al. 2003 Anti-remodeling effect of long-term exercise training in patients with stable chronic heart failure Circulation 108 554 559 10.1161/01.CIR.0000081780.38477.FA 12860904 (Pubitemid 36961169)
21. S Gielen V Adams S Mobius-Winkler, et al. 2003 Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure J Am Coll Cardiol 42 861 868 10.1016/S0735-1097(03)00848-9 1:CAS:528:DC%2BD3sXnsleitbY%3D 12957433 (Pubitemid 37059745)
22. F Roveda HR Middlekauff M Urbana, et al. 2003 The effects of exercise training on sympathetic neural activation in advanced heart failure J Am Coll Cardiol 42 854 860 10.1016/S0735-1097(03)00831-3 12957432 (Pubitemid 37059744)
23. M Jette R Heller F Landry G Blumchen 1991 Randomized 4-week exercise program in patients with impaired left ventricular function Circulation 84 1561 1567 1:STN:280:DyaK38%2Fgs1Smtw%3D%3D 1914097
24. J Myers D Wagner T Schertler, et al. 2002 Effects of exercise training on left ventricular volumes and function in patients with nonischemic cardiomyopathy: application of magnetic resonance myocardial tagging Am Heart J 144 719 725 12360170
25. R Hambrecht S Gielen A Link, et al. 2000 Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: a randomized trial JAMA 283 3095 3101 10.1001/jama.283.23.3095 1:STN:280:DC%2BD3czisFOjtA%3D%3D 10865304
26. RW Braith MA Welsch MS Feigenbaum, et al. 1999 Neuroendocrine activation in heart failure is modified by endurance exercise training J Am Coll Cardiol 34 1170 1175 10.1016/S0735-1097(99)00339-3 1:CAS:528:DyaK1MXntVWjs7o%3D 10520808 (Pubitemid 29500556)
27. Beckers PJ, Dennollet J, Possemiers NM, et al.: Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study. E Heart J 2008, 29:1858-1866.
28. D Curnier M Galinier A Pathak, et al. 2001 Rehabilitation of patients with congestive heart failure with or without beta-blockade therapy J Card Fail 7 241 248 10.1054/jcaf.2001.26565 1:STN:280:DC%2BD3Mrhs12ltw%3D%3D 11561225 (Pubitemid 32867964)
29. P Feiereisen C Delagardelle M Vaillant, et al. 2007 Is strength training the more efficient training modality in chronic heart failure? Med Sci Sports Exerc 39 1910 1917 10.1249/mss.0b013e31814fb545 17986897 (Pubitemid 350073353)
30. A Linke N Schoene S Gielen, et al. 2001 Endothelial dysfunction in patients with chronic heart failure: systemic effects of lower-limb exercise training J Am Coll Cardiol 37 392 397 10.1016/S0735-1097(00)01108-6 1:CAS:528:DC%2BD3MXhsl2jtL4%3D 11216952
31. J-Y Tabet P Meurin F Beauvais, et al. 2008 Absence of exercise capacity improvement after exercise training program a strong prognostic factor in patients with chronic heart failure Circ Heart Fail 1 220 226 10.1161/CIRCHEARTFAILURE.108.775460 19808295
32. U Wisloff A Stoylen JP Loennechen, et al. 2007 Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients a randomized study Circulation 115 3086 3094 10.1161/CIRCULATIONAHA.106.675041 17548726 (Pubitemid 46956498)
33. JF Forissier P Vernochet P Bertrand, et al. 2001 Influence of carvedilol on benefits of physical training in patients with moderate chronic heart failure European J Heart Failure 3 335 342 10.1016/S1388-9842(00)00152-5 1:CAS:528:DC%2BD3MXkvFymsrY%3D (Pubitemid 32895842)
34. CM O'Connor DJ Whellan KL Lee, et al. 2009 Efficacy and safety of exercise training in patients with chronic heart failure HF-ACTION randomized controlled trial. JAMA 301 1439 1450 This multisite clinical trial randomly assigned 2331 patients to receive either usual care or usual care plus regular exercise. In patients taking evidence-based therapy, exercise mildly reduced the risk for death and hospitalization and moderately reduced risk of cardiovascular death and heart failure hospitalization.
35. th Annual Scientific Session of the American College of Cardiology. Late Break Clinical Trial Oral Abstract Presentation. Orlando, FL; March 29, 2009. Accessible at http://directnews.americanheart.org/extras/pdfs/keteyian- accslides.pdf. Accessed November 2009. This secondary analysis of patients in the exercise arm of HF-ACTION showed that both the risk for clinical events and magnitude of increase in exercise capacity improved as the volume of exercise completed each week increased.
36. S Cazeau C Leclerco T Lavergne, et al. 2001 Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay N Engl J Med 344 873 880 10.1056/NEJM200103223441202 1:STN:280:DC%2BD3M7nsV2ltw%3D%3D 11259720 (Pubitemid 32224395)
37. M Guazzi P Palermo G Pontone, et al. 1999 Synergistic efficacy of enalapril and losartan on exercise performance and oxygen consumption at peak exercise in congestive heart failure Am J Cardiol 84 1038 1043 10.1016/S0002-9149(99)00495-6 1:CAS:528:DyaK1MXnvVGmsrc%3D 10569660 (Pubitemid 29505372)
38. MJ Haykowsky Y Liang D Pechter, et al. 2007 A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients J Am Coll Cardiol 49 2329 2336 10.1016/j.jacc.2007.02.055 17572248 This meta-analysis showed that regular aerobic-type exercise had small but favorable effects on both LVEF and end-diastolic volume. (Pubitemid 46891716)
39. SA Hunt WT Abraham MH Chin, et al. 2009 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 53 e1 e90 10.1016/j.jacc.2008.11.013 19358937
40. RW Braith DT Beck 2008 Resistance exercise: training adaptations and developing a safe exercise prescription Heart Fail Rev 13 69 79 10.1007/s10741-007-9055-9 17932746 (Pubitemid 350278735)
41. RS McKelvie N McCartney C Tomlinson, et al. 1995 Comparison of hemodynamic responses to cycling and resistance exercise in congestive heart failure secondary to ischemic cardiomyopathy Am J Cardiol 76 977 979 10.1016/S0002-9149(99)80277-X 1:STN:280:DyaK28%2FktFyquw%3D%3D 7484846
42. C Pu MT Johnson DE Forman, et al. 2001 Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure J Appl Physiol 90 2341 2350 1:STN:280:DC%2BD3M3msVGkuw%3D%3D 11356801
43. RS McKelvie KK Teo R Roberts, et al. 2002 Effects of exercise training for patients with heart failure: the Exercise Rehabilitation Trial (EXERT) Am Heart J 144 23 30 10.1067/mhj.2002.123310 12094184 (Pubitemid 34734751)
44. Rees K, Taylor RRS, Sing S, et al.: Exercise based rehabilitation for heart failure. Cochrane Database Syst Rev 2004, 3:CD003331.
45. KE Flynn IL Pina DJ Whellan 2009 Effects of exercise training on health status in patients with chronic heart failure HF-ACTION randomized controlled trial. JAMA 301 1451 1459 1:CAS:528:DC%2BD1MXkt1Onurs%3D A secondary end point in HF-ACTION, this study showed that exercise moderately improved health status beyond that observed among patients in the usual care-only arm of the trial.
46. SJ Keteyian D Issac U Thadani, et al. 2009 Safety of symptom-limited cardiopulmonary exercise testing in patents with chronic heart failure due to left ventricular systolic dysfunction Am Heart J 158 S72 S77 10.1016/j.ahj.2009.07.014 19782792 As in healthy individuals and other patients with cardiovascular disease, this study showed that symptom-limited maximal exercise testing is safe in patients with chronic HF. Major event rate was 0.45 per 1000 tests.
47. EA Normandin DN Camaione BA Clark, et al. 1993 A comparison of conventional versus anaerobic threshold exercise prescription methods in subjects with left ventricular dysfunction J Cardiolpulm Rehabil 13 110 116
48. J Dorn J Naughton D Imamura M Trevisan 2001 Correlates of compliance in a randomized exercise trial in myocardial infarction patients Med Sci Sports Exerc 33 1081 1089 1:STN:280:DC%2BD38%2FivVartA%3D%3D 11445753
49. GC Fonarow W Gattis WT Abraham, et al. 2007 Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure J Am Coll Cardiol 50 768 777 10.1016/j.jacc.2007.04.064 17707182 (Pubitemid 47243795)
50. N Smart B Haluska L Jeffriess TH Marwick 2007 Exercise training in systolic and diastolic dysfunction: effects on cardiac function, functional capacity, and quality of life Am Heart J 153 530 536 10.1016/j.ahj.2007.01.004 17383289 Most clinical exercise trials to date involving patients with HF only included patients with LV systolic dysfunction. This important study investigated the effects of exercise training in patients with HF and preserved systolic function. Favorable improvements in exercise capacity and quality of life resulted from regular exercise. (Pubitemid 46440684)