Genetic variants on apolipoprotein gene cluster influence triglycerides with a risk of coronary artery disease among Indians

Molecular Biology Reports

Volumn 37, Issue 1, 2010, Pages 521-527

  Ashokkumar, Manickaraj ^a   Subhashini, Navaneethan Gnana Veera ^a   Saibabu, Ramineni ^a   Ramesh, Arabandi ^c   Cherian, Kotturathu Mammen ^a   Emmanuel, Cyril ^b  

^a International Centre for Cardio Thoracic and Vascular Diseases   (India)

^b Global Hospitals and Health City   (India)

^c UNIVERSITY OF MADRAS   (India)

Author keywords

Apolipoprotein A5; Apolipoprotein C3; Coronary artery disease; Risk; Triglycerides

Indexed keywords

APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; TRIACYLGLYCEROL;

ADULT; ALLELE; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE CLUSTER; GENETIC RISK; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

APOLIPOPROTEINS; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HAPLOTYPES; HETEROZYGOTE; HUMANS; INDIA; MALE; MIDDLE AGED; MULTIGENE FAMILY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES;

EID: 77949263616     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9728-7     Document Type: Article

References (26)

1. AJ Lusis R Mar P Pajukanta 2004 Genetics of atherosclerosis Annu Rev Genomics Hum Genet 5 189 218 10.1146/annurev.genom.5.061903.175930 1:CAS:528:DC%2BD2cXosl2is7o%3D 15485348 (Pubitemid 39362746)
2. AJ Lusis AM Fogelman GC Fonarow 2004 Genetic basis of atherosclerosis: part I new genes and pathways Circulation 110 1868 1873 10.1161/01.CIR. 0000143041.58692.CC 15451808 (Pubitemid 39299231)
3. AJ Lusis 2000 Atherosclerosis Nature 407 233 241 10.1038/35025203 1:CAS:528:DC%2BD3cXmvVSlsrk%3D 11001066
4. P Joshi S Islam P Pais S Reddy P Dorairaj K Kazmi MP Pandey S Haque S Mendis S Rangarajan S Yusuf 2007 Risk factors for early myocardial infarction in South Asians compared with individuals in other countries JAMA 297 3 286 294 10.1001/jama.297.3.286 1:CAS:528:DC%2BD2sXotVClsg%3D%3D 17227980 (Pubitemid 46143306)
5. S Yusuf S Hawken S Ôunpuu L Bautista MG Franzosi P Commerford CC Lang Z Rumboldt CL Onen L Lisheng S Tanomsup P Wangai Jr F Razak AM Sharma SS Anand INTERHEART Study Investigators 2004 Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study Lancet 364 937 952 10.1016/S0140-6736(04)17018-9 15364185 (Pubitemid 39208455)
6. LA Pennacchio M Olivier JA Hubacek JC Cohen DR Cox JC Fruchart RM Krauss EM Rubin 2001 An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing Science 294 169 173 10.1126/science.1064852 1:CAS:528:DC%2BD3MXnsFyit7Y%3D 11588264 (Pubitemid 32952971)
7. PJ Talmud E Hawe S Martin M Olivier GJ Miller EM Rubin LA Pennacchio SE Humphries 2002 Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides Hum Mol Gen 11 24 3039 3046 10.1093/hmg/11.24.3039 1:CAS:528:DC%2BD38XosFOgsL4%3D 12417525
8. BE Aouizerat M Kulkarni D Heilbron D Drown S Raskin CR Pullinger MJ Malloy JP Kane 2003 Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids J Lipid Res 44 1167 1173 10.1194/jlr.M200480-JLR200 1:CAS:528:DC%2BD3sXltFars7w%3D 12671030 (Pubitemid 37279634)
9. C Lai LD Parnell JM Ordovas 2005 The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk Curr Opin Lipidol 16 153 166 10.1097/01.mol.0000162320.54795.68 1:CAS:528:DC%2BD2MXit1Oms74%3D 15767855
10. PJ Talmud SE Humphries 1997 Apolipoprotein C-III gene variation and dyslipidaemia Curr Opin Lipidol 8 154 158 10.1097/00041433-199706000-00005 1:CAS:528:DyaK2sXktlWlsbw%3D 9211063 (Pubitemid 27290461)
11. CC Shoulders PJ Harry L Lagrost SE White NF Shah JD North M Gilligan P Gambert MJ Ball 1991 Variation at the AI/CIII/AIV gene complex is associated with elevated plasma levels of apoCIII Atherosclerosis 87 239 247 10.1016/0021-9150(91)90026-Y 1:STN:280:DyaK3MzgslGksw%3D%3D 1906714
12. V Mohan R Deepa SS Rani G Premalatha Chennai Urban Population Study (CUPS No.5) 2001 Prevalence of coronary artery disease and its relationship to lipids in a selected population in South India: the Chennai urban population study (CUPS No. 5) J Am Coll Cardiol 38 3 682 687 10.1016/S0735-1097(01)01415-2 1:STN:280:DC%2BD3MvosFygsg%3D%3D 11527617 (Pubitemid 32835736)
13. R Begom RB Singh 1995 Prevalence of coronary artery disease and its risk factors in the urban population of South and North India Acta Cardiol 50 227 240 1:STN:280:DyaK2MvgslagsA%3D%3D 7676762
14. R Gupta P Joshi V Mohan KS Reddy S Yusuf 2008 Epidemiology and causation of coronary heart disease and stroke in India Heart 94 1 16 26 10.1136/hrt.2007.132951 1:STN:280:DC%2BD2sjks1Gntw%3D%3D 18083949
15. DK Lahiri B Schnabel 1993 DNA isolation by a rapid method from human blood samples: effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality Biochem Genet 31 7 321 328 10.1007/BF02401826 1:CAS:528:DyaK2cXjvFai 8274138 (Pubitemid 23316953)
16. S Chhabra DP Agarwal S Vasisht K Luthra R Narang SC Manchanda LM Srivastava N Das 2003 Study of apolipoproteinC3 Sst I polymorphism in healthy volunteers from Northern India Ind J Clin Biochem 18 2 34 38 10.1007/BF02867365
17. GR Chandak KJ Ward CS Yajnik AN Pandit A Bavdekar CV Joglekar CH Fall P Mohankrishna TJ Wilkin BS Metcalf MN Weedon TM Frayling AT Hattersley 2006 Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans BMC Med Genet 7 76 10.1186/1471-2350-7-76 17032446 (Pubitemid 44680220)
18. J Palmen AJ Smith B Dorfmeister W Putt SE Humphries PJ Talmud 2008 The functional interaction on in vitro gene expression of APOA5 SNPs, defining haplotype APOA52, and their paradoxical association with plasma triglyceride but not plasma apoAV levels Biochim Biophys Acta 1782 7-8 447 452 1:CAS:528:DC%2BD1cXnsFOrtr0%3D 18395529
19. N Bi SK Yan GP Li ZN Yin BS Chen 2005 A single nucleotide polymorphism -1131T>C in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and alters triglyceride metabolism in Chinese Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22 3 281 283 (Abstract)
20. LA Hsu YL Ko CJ Chang MS Teng S Wu CF Hu 2008 Apolipoprotein A5 gene -1131T/C polymorphism is associated with the risk of metabolic syndrome in ethnic Chinese in Taiwan Clin Chem Lab Med 46 12 1714 1719 10.1515/CCLM.2008.352 1:CAS:528:DC%2BD1MXns1Cqtw%3D%3D 19055447
21. Cardona F, Guardiola M, Queipo-Ortuño MI, Murri M, Ribalta J, Tinahones FJ (2009) The -1131T>C SNP of the APOA5 gene modulates response to fenofibrate treatment in patients with the metabolic syndrome: a postprandial study. Atherosclerosis. Mar 11 (epub ahead of print)
22. J Ribalta L Figuera J Fernández-Ballart E Vilella M Castro Cabezas L Masana J Joven 2002 Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia Clin Chem 48 9 1597 1600 1:CAS:528:DC%2BD38XmslSqu7Y%3D 12194944
23. J Shanker G Perumal VS Rao NB Khadrinarasimhiah S John S Hebbagodi M Mukherjee VV Kakkar 2008 Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease Lipids Health Dis 7 33 10.1186/1476-511X-7-33 18801202
24. EA Ruiz-Narváez FM Sacks H Campos 2008 Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction Am J Clin Nutr 87 6 1932 1938 18541587
25. S Chhabra R Narang LR Krishnan S Vasisht DP Agarwal LM Srivastava SC Manchanda N Das 2002 Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians BMC Genet 3 9 10.1186/1471-2156-3-9 1:STN:280: DC%2BD38nosVWjtQ%3D%3D 12052247 (Pubitemid 38751040)
26. PJ Talmud S Martin MR Taskinen MH Frick MS Nieminen YA Kesäniemi A Pasternack SE Humphries M Syvänne 2004 APOA5 gene variants, lipoprotein particle distribution, and progression of coronary heart disease: results from the LOCAT study J Lipid Res 45 4 750 756 10.1194/jlr.M300458-JLR200 1:CAS:528:DC%2BD2cXjtFWmsbY%3D 14729863 (Pubitemid 38405682)