Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation

Neuroendocrinology Letters

Volumn 31, Issue 1, 2010, Pages 147-154

  Xu, Tongjiang ^a   Ye, Fei ^a   Wang, Baofeng ^a   Tian, Chunlei ^a   Wang, Sheng ^a   Shu, Kai ^a   Guo, Dongsheng ^a   Lei, Ting ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

GH secreting pituitary adenomas; Ghrelin mRNA; GHSR 1a mRNA; Gsp mutation; Tumor size

Indexed keywords

GENOMIC DNA; GHRELIN RECEPTOR; GROWTH HORMONE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MESSENGER RNA; SOMATOMEDIN;

ACROMEGALY; ARTICLE; CANCER INVASION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; GROWTH HORMONE SECRETING ADENOMA; HUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TUMOR VOLUME;

EID: 77749330058     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Bai X, Lei T, Liu K. (2000). Clinical and biochemical characteristics of growth hormone-secreting pituitary tumors. J Tongji Med Univ. 20: 212-213.
2. Buchfelder M, Fahlbusch R, Merz T, Symowski H, Adams EF. (1999). Clinical correlates in acromegalic patients with pituitary tumors expressing GSP oncogenes. Pituitary. 1: 181-185.
3. Dixit VD, Weeraratna AT, Yang H, Bertak D, Cooper-Jenkins A, Riggins GJ, et al. (2006). Ghrelin and the growth hormone secretogogue receptor constitute a novel autocrine pathway in astrocytoma motility. J Biol Chem. 281: 16681-16690.
4. Grossman AB. (2009). The molecular biology of pituitary tumors: a personal perspective. Pituitary. 12: 265-270.
5. Hosoi E, Yokogoshi Y, Hosoi E, Horie H, Sano T, Yamada S, et al. (1993). Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues. Acta Endocrinol (Copenh). 129: 301-306.
6. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, et al. (1996). A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 273: 974-947.
7. Kan B, Esapa C, Sipahi T, Nacar C, Ozer F, Sayhan NB, et al. (2003). G protein mutations in pituitary tumors: a study on Turkish patients. Pituitary. 6: 75-80.
8. Kim E, Sohn S, Lee M, Park C, Jung J, Park S. (2005). Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells. Pituitary. 8: 155-162.
9. Kim K, Arai K, Sanno N, Osamura RY, Teramoto A, Shibasaki T. (2001). Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas. Clin Endocrinol (Oxf). 54: 759-768.
10. Kim K, Sanno N, Arai K, Takano K, Yasufuku-Takano J, Teramoto A, et al. (2003). Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein. Clin Endocrinol (Oxf). 59: 630-636.
11. Kineman RD, Kamegai J, Frohman LA. (1999). Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels. Endocrinology. 140: 3581-3586.
12. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 402: 656-660.
13. Lei T, Adams EF, Buchfelder M, Fahlbusch R. (1996). Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas. Neurosurgery. 39: 569-75; discussion 575-576.
14. Lei T, Yang B, Shu K, Dong F, Xue D, LI Ling, Jiang X. (2002). Analysis of the clinical biochemical characteristics of the growth hormone-secreting pituitary adenoma. Chin J Neurosurg Dis Res. 1: 164-166.
15. Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25: 402-408.
16. Machado MC, Sa SV, Goldbaum TS, Catania M, Campos VC, Correa-Giannella ML, et al. (2007). In vivo response to growth hormone-releasing peptide-6 in adrenocorticotropin-dependent Cushing's syndrome by lung carcinoid tumor is associated with growth hormone secretagogue receptor type 1a mRNA expression. J Endocrinol Invest. 30: 334-340.
17. Morita K, Takano K, Yasufuku-Takano J, Yamada S, Teramoto A, Takei M, et al. (2008). Expression of pituitary tumour-derived, N-terminally truncated isoform of fibroblast growth factor receptor 4 (ptd-FGFR4) correlates with tumour invasiveness but not with G-protein alpha subunit (gsp) mutation in human GH-secreting pituitary adenomas. Clin Endocrinol (Oxf). 68: 435-441.
18. Nanzer AM, Khalaf S, Mozid AM, Fowkes RC, Patel MV, Burrin JM, et al. (2004). Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 151: 233-240.
19. Sakai N, Kim K, Sanno N, Yoshida D, Teramoto A, Shibasaki T. (2008). Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. Neurol Med Chir (Tokyo). 48: 481-7; discussion 487-488.
20. Skinner MM, Nass R, Lopes B, Laws ER, Thorner MO. (1998). Growth hormone secretagogue receptor expression in human pituitary tumors. J Clin Endocrinol Metab. 83: 4314-4320.
21. Yasufuku-Takano J, Takano K, Morita K, Takakura K, Teramoto A, Fujita T. (2006). Does the prevalence of gsp mutations in GH-secreting pituitary adenomas differ geographically or racially? Prevalence of gsp mutations in Japanese patients revisited. Clin Endocrinol (Oxf). 64: 91-96.
22. Yoshimoto K, Iwahana H, Fukuda A, Sano T, Itakura M. (1993). Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis. Cancer. 72: 1386-1393.