G protein mutations in pituitary tumors: A study on Turkish patients

Pituitary

Volumn 6, Issue 2, 2003, Pages 75-80

  Kan, Beki ^a   Esapa, Christopher ^b,e   Sipahi, Tammam ^a   Nacar, Cevdet ^a   Özer, Fahir ^c   Sayhan, Nur Buyru ^d   Kaynar, Mehmet Yaşar ^d   Sarioǧlu, Ali Çetin ^c,d   Harris, Philip Edward ^b  

^a MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Department of Neurosurgery   (Turkey)

^d ISTANBUL UNIVERSITY   (Turkey)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adenylyl cyclase; G protein mutations; Pituitary tumors; Protein kinase A

Indexed keywords

ADENYLATE CYCLASE; ARGININE; CORTICOTROPIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE; GENOMIC DNA; GROWTH HORMONE; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSINE; OLIGONUCLEOTIDE; ONCOPROTEIN; THREONINE;

ADULT; AGED; ALLELE; ARTICLE; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; DNA DETERMINATION; DNA HYBRIDIZATION; DNA SEQUENCE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ETHNOLOGY; FEMALE; FREQUENCY ANALYSIS; FUNCTIONAL ASSESSMENT; GENDER; GENE ACTIVATION; GENE AMPLIFICATION; GENE IDENTIFICATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; HYPOPHYSIS TUMOR; INTRON; MALE; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROLACTINOMA; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR RECURRENCE; TURKEY (REPUBLIC);

ADULT; ALLELES; AUTORADIOGRAPHY; DNA; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GTP-BINDING PROTEINS; HUMANS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; MUTAGENESIS; MUTATION; OLIGONUCLEOTIDES; PITUITARY NEOPLASMS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TURKEY;

EID: 0346146990     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PITU.0000004797.89592.5e     Document Type: Article

References (28)

1. Hepler JR, Gilman AG. G proteins. Trends Biochem Sci 1992;17:383-387.
2. Dhanasekaran N, Heasley LE, Johnson GL. G protein-coupled receptor systems involved in cell growth and oncogenesis. Endocr Rev 1995;16:259-270.
3. s and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature 1987;330:566-568.
4. s and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989;340:692-696.
5. Lyons J, Landis CA, Harsh G, Vallar L, Grünewald, K, Feichtinger H, Duh Q-Y, Clark OH, Kawasaki, E, Bourne HR, McCormick F. Two G protein oncogenes in human endocrine tumors. Science 1990;249:655-659.
6. O'Sullivan C, Barton CM, Staddon SL, Brown CL, Lemoine NR. Activating point mutations of the gsp oncogene in human thyroid adenomas. Mol Carcinogen 1991;4:345-349.
7. Williamson EA, Daniels M, Foster S, Kelly WF, Kendall-Taylor P, Harris PE. Gsα and Gi2α mutations in clinically non-functioning pituitary tumours. Clin Endocrinol 1994;41:815-820.
8. Orellana SA, McKnight GS. Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity. Proc Natl Acad Sci USA 1992;89:4726-4730.
9. Davis LG, Dibner MD, Matley JF. Rapid DNA preparation. In: Davis LG, Dibner MD, Battey JF, eds. Basic Methods in Molecular Biology. New York, Amsterdam, London: Elsevier, 1986:42-43.
10. Clementi E, Malgaretti N, Meldolesi J, Taramelli R. A new constitutively activating mutation of the G. protein a subunit-gsp oncogene is found in human pituitary tumours. Oncogene 1990;5:1059-1061.
11. sα mutations. J Clin Endocrinol Metab 1992;75:918-923.
12. Drews RT, Gravel RA, Collu R. Identification of G protein α subunit mutations in human growth hormone (GH) and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis. Mol Cell Endocrinol 1992;87:125-129.
13. Adams EF, Brockmeier S, Friedmann E, Roth M, Buchfelder M, Fahlbusch R. Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors. Neurosurgery 1993;33:198-203.
14. Hosoi E, Yokogoshi Y, Hosoi E, Horie H, Sano T, Yamada S, Saito S. Analysis of the Gsα gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues. Acta Endocrinol 1993;129:301-306.
15. Yoshimoto K, Iwahana H, Fukuda A, Sano T, Itakura M. Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Cancer 1993;72:1386-1393.
16. Yang I, Park S, Ryu M, Woo J, Kim S, Kim J, Kim Y, Choi Y. Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. Eur J Endocrinol 1996;134:720-726.
17. Tordjman K, Stern N, Ouaknine G, Yossiphov Y, Razon N, Nordenskjold M, Friedman E. Activating mutations of the Gs α-gene in nonfunctioning pituitary tumors. J Clin Endocrinol Metab 1993;77:765-769.
18. Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTeman F, Perrett CW, Thakker RV, Clayton RN. Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab 1994;78:387-392.
19. Vallar L. Oncogenic role of heterotrimeric G proteins. In: Tooze J, Parker PJ, Pawson T, eds. Cancer Surveys. New York: Cold Spring Harbor Laboratory Press, 1996:325-338.
20. Ballaré E, Mantovani S, Lania A, DiBlasio AM, Vallar L, Spada A. Activating mutations of the Gsα gene are associated with low levels of Gsα protein in growth-hormone secreting tumors. J Clin Endocrinol Metab 1998;83:4386-4390.
21. i2α, and somatostatin receptor2 in human somatotroph adenomas involvement in octreotide sensitivity. J Clin Endocrinol Metab 1999;84:2759-2765.
22. Lania A, Persani L, Ballaré E, Mantovard S, Losa M, Spada A. Constitutively active Gsα is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas. J Clin Endocrinol Metab 1998;83:1624-1628.
23. s protein mutations and the pathogenesis and function of pituitary tumors. Metabolism 1996;45:120-122.
24. s protein mutations and pituitary tumors. Functional correlates and possible therapeutic implications. Metabolism 1996;45:117-119.
25. Spada A, Arosio M, Bochicchio D, Bazzord N, Vallar L, Bassetti M, Faglia G. Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab 1990;71:1421-1426.
26. Yang IM, Woo JT, Kim SW, Kim YS, Choi YK. Characteristics of acromegalic patients with a good response to octreotide, a somatostatin analogue. Clin Endocrinol 1995;42:295-301.
27. Gonzales GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989;59:675-680.
28. Esapa CT, Harris PE. Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumors. Eur J Endocrinol 1999;141:409-412.