Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells

Journal of Cellular Biochemistry

Volumn 109, Issue 4, 2010, Pages 634-642

  McHenry, Peter ^a,b   Wang, Wei Lin Winnie ^c   Devitt, Edward ^b   Kluesner, Nicholas ^b   Davisson, Vincent Jo ^d   McKee, Edward ^a   Schweitzer, Dirk ^b   Helquist, Paul ^b   Tenniswood, Martin ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

^c UNIVERSITY AT ALBANY   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Breast cancer; Cell cycle; Lysosome; Macrolide; Mitochondria; Reactive oxygen species; V ATPase

Indexed keywords

DNA; IEJIMALIDE A; IEJIMALIDE B; MACROLIDE; NATURAL PRODUCT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL DEATH; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOPLASM; DNA CONTENT; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HEART MITOCHONDRION; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

APOPTOSIS; BREAST NEOPLASMS; CARBAMATES; CELL LINE, TUMOR; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; LYSOSOMES; MACROLIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; S PHASE; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 77749321292     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22438     Document Type: Article

References (21)

1. Beltran AR, Ramirez MA, Carraro-Lacroix LR, Hiraki Y, Reboucas NA, Malnic G. 2008. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. Pflugers Arch 455:799-810.
2. Beyenbach KW, Wieczorek H. 2006. The V-type H+ ATPase: Molecular structure and function, physiological roles and regulation. J Exp Biol 209: 577-589.
3. Blomgran R, Zheng L, Stendahl O. 2007. Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol 81:1213-1223.
4. Boron WF. 2004. Regulation of intracellular pH. Advan Physiol Educ 28:160-179.
5. Counis MF, Torriglia A. 2006. Acid DNases and their interest among apoptotic endonucleases. Biochimie 88:1851-1858.
6. Eastman A. 2004. Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J Cell Biochem 91:223-231.
7. Furstner A, Nevado C, Tremblay M, Chevrier C, Teply F, Aissa C, Waser M. 2006. Total synthesis of iejimalide B. Angew Chem Int Ed Engl 45:5837-5842.
8. Huss M, Sasse F, Kunze B, Jansen R, Steinmetz H, Ingenhorst G, Zeeck A, Wieczorek H. 2005. Archazolid and apicularen: Novel specific V-ATPase inhibitors. BMC Biochem 6:13.
9. Kazami S, Muroi M, Kawatani M, Kubota T, Usui T, Kobayashi J, Osada H. 2006. Iejimalides show anti-osteoclast activity via V-ATPase inhibition. Biosci Biotechnol Biochem 70:1364-1370.
10. Kikuchi Y, Ishibashi M, Sasaki T, Kobayashi Ji. 1991. Iejimalides C and D, new antineoplastic 24-membered macrolide sulfates from the Okinawan Marine Tunicate Eudistoma cf RIGIDA. Tetrahedron Lett 32:797-798.
11. Kobayashi J, Cheng J, Ohta T, Nakamura H, Nozoe S, Hirata Y, Ohizumi Y, Sasaki T. 1988. Iejimalides A and B, novel 24-membered macrolides with potent antileukemic activity from the Okinawa Tunicate Eudistoma cf rigida. J Org Chem 53:6147-6150.
12. McKee EE, Grier BL, Thompson GS, McCourt JD. 1990. Isolation and incubation conditions to study heart mitochondrial protein synthesis. Am J Physiol 258:E492-E502.
13. Milgrom E, Diab H, Middleton F, Kane PM. 2007. Loss of vacuolar proton-translocating ATPase activity in yeast results in chronic oxidative stress. J Biol Chem 282:7125-7136.
14. Nakashima S, Hiraku Y, Tada-Oikawa S, Hishita T, Gabazza EC, Tamaki S, Imoto I, Adachi Y, Kawanishi S. 2003. Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1. J Biochem (Tokyo) 134:359-364.
15. Noguchi K, Fukazawa H, Murakami Y, Uehara Y. 2002. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. J Biol Chem 277:39655-39665.
16. Nozawa K, Tsuda M, Ishiyama H, Sasaki T, Tsuruo T, Kobayashi J. 2006. Absolute stereochemistry and antitumor activity of iejimalides. Bioorg Med Chem 14:1063-1067.
17. Schweitzer D, Kane JJ, Strand D, McHenry P, Tenniswood M, Helquist P. 2007. Total synthesis of iejimalide B. An application of the Shiina macrolactonization. Org Lett 9:4619-4622.
18. Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS. 2001. Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 276:3149-3157.
19. Teplova VV, Tonshin AA, Grigoriev PA, Saris NE, Salkinoja-Salonen MS. 2007. Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions. J Bioenerg Biomembr 39:321-329.
20. Turk B, Stoka V. 2007. Protease signalling in cell death: Caspases versus cysteine cathepsins. FEBS Lett 581:2761-2767.
21. Wang W, McHenry P, Jeffrey R, Schweitzer D, Helquist P, Tenniswood M. 2008. Effects of iejimalide B, a marine macrolide, on growth and apoptosis in prostate cancer cell lines. J Cell Biochem 105:998-1007.