The spatial resolution of silicon-based electron detectors in β-autoradiography

Physics in Medicine and Biology

Volumn 55, Issue 6, 2010, Pages 1677-1699

  Cabello, Jorge ^a   Wells, Kevin ^a,b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGE DIFFUSION; CRITICAL PARAMETER; DETECTOR NOISE; DIRECT CONTACT; ELECTRON DETECTORS; EX-VIVO; HIGH SPATIAL RESOLUTION; IMAGING MODALITY; IMAGING TECHNOLOGY; LOW ENERGIES; OPTIMAL DETECTORS; PIXEL SIZE; RADIOLIGANDS; SILICON-BASED; SILICON-BASED TECHNOLOGY; SILVER HALIDE CRYSTALS; SPATIAL RESOLUTION; TISSUE SECTIONS;

CRYSTALS; DETECTORS; IMAGE RESOLUTION; RADIOGRAPHY; RADIOISOTOPES; SILICON DETECTORS; SILVER HALIDES;

SILVER;

HALOGEN; RADIOISOTOPE; SILICON; SILVER DERIVATIVE;

ABSORPTION; ARTICLE; AUTORADIOGRAPHY; CHEMISTRY; COMPUTER SIMULATION; DIFFUSION; ELECTRON; EQUIPMENT DESIGN; INSTRUMENTATION; METHODOLOGY; MONTE CARLO METHOD; SENSITIVITY AND SPECIFICITY;

ABSORPTION; AUTORADIOGRAPHY; BETA PARTICLES; COMPUTER SIMULATION; DIFFUSION; ELECTRONS; EQUIPMENT DESIGN; HALOGENS; MONTE CARLO METHOD; RADIOISOTOPES; SENSITIVITY AND SPECIFICITY; SILICON; SILVER COMPOUNDS;

EID: 77749307231     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/55/6/010     Document Type: Article

References (50)

1. Agostinelli S 2002 GEANT4: A simulation toolkit Nucl. Instrum. Methods Phys. Res. Section A 506 250-303
2. Amako K, et al. 2005 Comparison of Geant4 electromagnetic physics models against the NIST reference data IEEE Trans. Nucl. Sci. 52 910-8
3. Amendolia S, et al. 1997 Use of silicon and GaAs pixel detectors for digital autoradiography IEEE Trans. Nucl. Sci. 44 929-33
4. Baro J, Sempau J, Fernandez-Varea J M and Salvat F 1995 PENELOPE: an algorithm for Monte Carlo simulation of the penetration and energy loss of electrons and positrons in matter Nucl. Instrum. Methods Phys. Res. Section A 100 31-46
5. Barthe N, Chatti K, Coulon P, Maitrejean S and Basse-Cathalinat B 2004 Recent technologic developments on high resolution beta imaging for quantitative autoradiography and double labeling applications Nucl. Instrum. Methods Phys. Res. Section A 527 41-5
6. Bateman J E, Connolly J F and Stephenson R 1985 Improving the performance of the MWPC x-ray imaging detector by means of the multi-step avalanche technique Nucl. Instrum. Methods Phys. Res. Section A 239 251-9
7. Bellazzini R, Betti C, Brez A, Carboni E, Del Guerra A, Massai M and Torquati M R 1985 Multitracer digital autoradiography with MWPCs IEEE Trans. Nucl. Sci. 32 393-6
8. Bertolucci E, et al. 1996 Autoradiography with silicon strip detectors Nucl. Instrum. Methods Phys. Res. Section A 381 527-30
9. Bonazzola G C and Ropolo R 1985 Charge coupled devices as autoradiography imagers IEEE Trans. Nucl. Sci. 32 567-70
10. Bootsma T M V, van Zwet E J, Brinkman A C, den Herder J W, de Jong L, de Korte P and Olsthoorn S M 2000 Synchrotron calibration and response modelling of back-illuminated XMM-RGS CCDs Nucl. Instrum. Methods Phys. Res. Section A 439 575-81
11. Briesmeister J 2000 MCNP-A General Monte Carlo N-Particle Transport Code version 4C LA-13709-M (April 2000)
12. Cabello J and Wells K 2007 A Monte Carlo investigation into the fundamental limitations of digital β-autoradiography: considerations for detector design Nuclear Science Symp. Conf. Record 2007 NSS '07. IEEE' 5 3625-30
13. Cabello J, Bailey A, Kitchen I, Prydderch M, Clark A, Turchetta R and Wells K 2007 Digital autoradiography using room temperature CCD and CMOS imaging technology Phys. Med. Biol. 52 4993-5011 (Pubitemid 47232301)
14. Cabello J, Wells K, Metaxas A, Bailey A, Kitchen I, Clark A, Prydderch M and Turchetta R 2007 Digital autoradiography imaging using CMOS technology: first tritium autoradiography with a back-thinned CMOS detector and comparison of CMOS imaging performance with autoradiography film Nuclear Science Symp. Conf. Record, 2007. NSS '07. IEEE' 5 3743-6
15. Cappellini C, Bulgheroni A, Caccia M, Chmill V, Jastrzab M, Risigo F and Scopelliti P 2008 Imaging of biological samples with silicon pixel detectors Nucl. Instrum. Methods Phys. Res. Section A 591 34-7
16. Charpak G, Bouclier R, Bressani T, Favier J and Zupancic C 1968 The use of multiwire proportional counters to select and localise charged particles Nucl. Instrum. Methods Phys. Res. Section A 62 262-8
17. Charpak G and Sauli F 1978 The multistep avalanche chamber: a new high-rate, high-accuracy gaseous detector Phys. Lett. B 78 523-8
18. Chen L, Gobar L S, Knowles N G, Liu Z, Gmitro A F and Barrett H H 2008 Direct imaging of radionuclide produced electrons and positrons with an ultrathin phosphor J. Nucl. Med. 49 1141-5
19. Cherry S R, Sorenson J A and Phelps M E 2003 Physics in Nuclear Medicine (Philadelphia, PA: Saunders)
20. Deptuch G 2005 Tritium autoradiography with thinned and back-side illuminated monolithic active pixel sensor device Nucl. Instrum. Methods Phys. Res. Section A 543 537-48
21. Hopkinson G R 1987 Analytic modeling of charge diffusion in charge-coupled-device imagers Opt. Eng. 26 766-72
22. ICRU 1984 Stopping powers for electrons and positrons Technical Report 37 (Bethesda, MD: ICRU)
23. Janesick J 2002 Dueling detectors Proc. SPIE A 4669 30-3
24. Janesick J, Elliot T, Collins S, Daud T, Campbell D and Dingzian A 1985 CCD advances for x-ray scientific measurements in 1985 SPIE Proc. X-ray Instrum. Astron. 597 364-80
25. Klein P, et al. 2000 A DEPFET pixel Bioscope for the use in autoradiography Nucl. Instrum. Methods Phys. Res. Section A 454 152-7
26. Kokkinou E, Wells K, Petrou M and Bailey A 2003 Digital autoradiography imaging using direct irradiation of a CCD between 278-309 K IEEE Trans. Nucl. Sci. 50 1702-7
27. 14C autoradiography IEEE Trans. Nucl. Sci. 45(2) 1288-92
28. Lees J E, Murray A, Perkins A C and Fraser G W 2002 Autoradiography of high-energy radionuclides using a microchannel plate detector IEEE Trans. Nucl. Sci. 49 153-5
29. Lees J E, Pearson J F, Fraser G W, Hales J M and Richards P G 1999 An MCP-based system for beta autoradiography IEEE Trans. Nucl. Sci. 46 636-8
30. Magnan P 2003 Detection of visible photons in CCD and CMOS: a comparative view Nucl. Instrum. Methods Phys. Res. Section A 504 199-212
31. McCarthy K J, Owens A, Holland A D and Wells A A 1995 Modelling the x-ray response of charge coupled devices Nucl. Instrum. Methods Phys. Res. Section A 362 538-46
32. Mettivier G, Montesi M C and Russo P 2003 First images of a digital autoradiography system based on a Medipix2 hybrid silicon pixel detector Phys. Med. Biol. 48 173-81
33. 14C microscales Nucl. Instrum. Methods Phys. Res. Section A 518 404-5
34. Mettivier G, Montesi M C and Russo P 2004 Tritium digital autoradiography with a Medipix2 hybrid silicon pixel detector Nucl. Instrum. Methods Phys. Res. Section A 516 554-63
35. Mettivier G, Montesi M C and Russo P 2005 Digital autoradiography with a Medipix2 hybrid silicon pixel detector IEEE Trans. Nucl. Sci. 52 46-50
36. Neeser W, et al. 2000 The DEPFET pixel BIOSCOPE IEEE Trans. Nucl. Sci. 47 1246-50
37. NIST 1901 National Institute of Standards and Technology http://www.nist.gov/index.html
38. Orbom A, Dahlbom M, Olafsen T, Wu A M and Strand S 2007 Serial digital autoradiography with a silicon strip detector as a high resolution imaging modality for TRT dosimetry Nuclear Science Symp. Conf. Record, 2007. NSS '07. IEEE' 6 4054-6
39. Ott R J, MacDonald J and Wells K 2000 The performance of a CCD digital autoradiography imaging system Phys. Med. Biol. 45 2011-27
40. Overdick M, et al. 1997 A 'Bioscope' system using double-sided silicon strip detectors and self-triggering read-out chips Nucl. Instrum. Methods Phys. Res. Section A 392 173-7
41. Pavlov G G and Nousek J A 1999 Charge diffusion in CCD x-ray detectors Nucl. Instrum. Methods Phys. Res. Section A 428 348-66
42. Petegnief Y, Petiet A, Peker M C, Bonnin F, Meulemans A and Le Guludec D 1998 Quantitative autoradiography using a radioimager based on a multiwire proportional chamber Phys. Med. Biol. 43 3629-38
43. Prigozhin G, Butler N R, Kissel S E and Ricker G R 2003 An experimental study of charge diffusion in the undepleted silicon of x-ray CCDs IEEE Trans. Electron Devices 50 246-53
44. Rogers D W O and Bielajew A F 1995 The use of EGS for Monte Carlo calculations in medical physics Nucl. Instrum. Methods Phys. Res. Section A 100 31-46
45. 18F-FDG positron autoradiography with a particle counting silicon pixel detector Phys. Med. Biol. 53 6227-43
46. Sanghera B and Ott R J 1993 Preliminary studies using silicon strip detectors in digital autoradiography IEEE Trans. Nucl. Sci. 40 992-5
47. Stumpf W 2003 Drug Localization in Tissues and Cells (Chapel Hill, NC: IDDC Press)
48. Tribollet E, Dreiffus J J, Charpak G, Dominik W and Zaganidis N 1991 Localization and quantitation of tritiated compounds in tissue sections with a gaseous detector of β particles: comparison with film autoradiography Proc. Natl Acad. Sci. 88 1466-8
49. Ulrici J, Fischer P, Klein P, Lutz G, Neeser W, Richter R, Strüder L, Trimpf M and Wermes N 2005 Imaging performance of a DEPFET pixel bioscope system in tritium autoradiography Nucl. Instrum. Methods Phys. Res. Section A 547 434-36
50. Yamane Y, Ishide N, Kagaya Y, Takeyama D, Shiba N, Chida M, Sekiguchi Y, Nozaki T, Ido T and Shirato K 1995 Quantitative double-tracer autoradiography with tritium and Carbon-14 using imaging plates: application to myocardial metabolic studies in rats J. Nucl. Med. 36 518-24