The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change

Biochemistry

Volumn 49, Issue 8, 2010, Pages 1628-1639

  Matveev, Alexander V ^a   Fitzgerald, J Browning ^a   Xu, Jianhua ^a   Malykhina, Anna P ^a,c   Rodgers, Karla K ^b   Ding, Xi Qin ^a  

^a Department of Cell Biology ^*  (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE EFFECT; ALLOSTERIC TRANSITION; C-TERMINAL DOMAINS; C-TERMINUS; CARBOXYL TERMINUS; CIRCULAR DICHROISM SPECTRA; CONE PHOTORECEPTORS; CONFORMATIONAL CHANGE; CYCLIC NUCLEOTIDE; CYTOSOLIC; ELECTROPHYSIOLOGICAL RECORDINGS; FOLDED STRUCTURES; FUNCTIONAL ACTIVITIES; GATED CHANNELS; GLUTATHIONE-S-TRANSFERASE; HEK-293; HELICAL CONTENT; HETEROLOGOUS EXPRESSION; INTRACELLULAR CA; RATIOMETRIC; SECONDARY STRUCTURES; STRUCTURAL IMPACT; WILD TYPES;

CALCIUM; DICHROISM; SPECTRUM ANALYSIS; SPECTRUM ANALYZERS;

NUCLEOTIDES;

CYCLIC NUCLEOTIDE GATED CHANNEL; GLUTATHIONE TRANSFERASE; MUTANT PROTEIN; NUCLEOTIDE; PROTEIN SUBUNIT;

ALLOSTERISM; ARTICLE; CARBOXY TERMINAL SEQUENCE; ESCHERICHIA COLI; GENE MUTATION; IMMUNOFLUORESCENCE TEST; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RADIOMETRY;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE; CIRCULAR DICHROISM; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHYSIOLOGY; ESCHERICHIA COLI; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ESCHERICHIA;

EID: 77749298947     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901960u     Document Type: Article

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