Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas

Carcinogenesis

Volumn 26, Issue 7, 2005, Pages 1233-1240

  Pedersen, Tanja Xenia ^a   Pennington, Caroline J ^b   Almholt, Kasper ^a   Christensen, Ib Jarle ^a   Nielsen, Boye Schnack ^a   Edwards, Dylan R ^b   Rømer, John ^a   Danø, Keld ^a   Johnsen, Morten ^a,c  

^a FINSEN LABORATORY   (Denmark)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; GELATINASE A; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; STROMELYSIN; STROMELYSIN 3; UROKINASE; VIRUS ANTIGEN; PEPTIDE HYDROLASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST TUMOR; CANCER THERAPY; CELL INTERACTION; CELL ISOLATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE INDUCTION; IN SITU HYBRIDIZATION; LASER CAPTURE MICRODISSECTION; METHODOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; STATISTICAL ANALYSIS; STROMA CELL; TUMOR CELL; TUMOR GROWTH; ANIMAL; ANIMAL DISEASE; BIOSYNTHESIS; CARCINOMA; EXPERIMENTAL NEOPLASM; GENETICS; POLYMERASE CHAIN REACTION;

ANIMALS; CARCINOMA; FEMALE; MAMMARY NEOPLASMS, ANIMAL; MICE; PEPTIDE HYDROLASES; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; STROMAL CELLS;

EID: 22844435223     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi065     Document Type: Article

References (37)

1. Danø,K., Grøndahl-Hansen,J., Eriksen,J., Nielsen,B.S., Rømer,J. and Pyke,C. (1993) Stromal cell involvement in extracellular proteolysis during cancer invasion. In Barrett,A.J. and Bond,J. (eds), Proteolysis and Protein Turnover. Portland Press, London, pp. 239-245.
2. Johnsen,M., Lund,L.R., Romer,J., Almholt,K. and Danø,K. (1998) Cancer invasion and tissue remodeling: Common themes in proteolytic matrix degradation. Curr. Opin. Cell Biol., 10, 667-671.
3. Elenbaas,B. and Weinberg,R.A. (2001) Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp. Cell Res., 264, 169-184.
4. Pollard,J.W. (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer, 4, 71-78.
5. Danø,K., Andreasen,P.A., Grondahl-Hansen,J., Kristensen,P., Nielsen,L.S. and Skriver,L. (1985) Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res., 44, 139-266.
6. Andreasen,P.A., Egelund,R. and Petersen,H.H. (2000) The plasminogen activation system in tumor growth, invasion, and metastasis. Cell. Mol. Life Sci., 57, 25-40.
7. Egeblad,M. and Werb,Z. (2002) New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer, 2 161-174.
8. Freije,J.M., Balbin,M., Pendas,A.M., Sanchez,L.M., Puente,X.S. and Lopez-Otin,C. (2003) Matrix metalloproteinases and tumor progression. Adv. Exp. Med. Biol., 532, 91-107.
9. Blasi,F., Vassalli,J.D. and Danø,K. (1987) Urokinase-type plasminogen activator: Proenzyme, receptor, and inhibitors. J. Cell Biol., 104, 801-804.
10. Nielsen,B.S., Sehested,M., Timshel,S., Pyke,C. and Danø,K. (1996) Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer. Lab. Invest., 74, 168-177.
11. Offersen,B.V., Nielsen,B.S., Hoyer-Hansen,G., Rank,F., Hamilton-Dutoit,S., Overgaard,J. and Andreasen,P.A. (2003) The myofibroblast is the predominant plasminogen activator inhibitor-1-expressing cell type in human breast carcinomas. Am. J. Pathol., 163, 1887-1899.
12. Okada,A., Bellocq,J.P., Rouyer,N., Chenard,M.P., Rio,M.C., Chambon,P. and Basset, P. (1995) Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc. Natl Acad. Sci. USA, 92, 2730-2734.
13. Heppner,K.J., Matrisian,L.M., Jensen,R.A. and Rodgers,W.H. (1996) Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am. J. Pathol., 149, 273-282.
14. Nielsen,B.S., Sehested,M., Kjeldsen,L., Borregaard,N., Rygaard,J. and Danø,K. (1997) Expression of matrix metalloprotease-9 in vascular pericytes in human breast cancer. Lab. Invest., 77, 345-355.
15. Wolf,C., Rouyer,N., Lutz,Y., Adida,C., Loriot,M., Bellocq,J.P., Chambon,P. and Basset P. (1993) Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression. Proc. Natl Acad. Sci. USA 90, 1843-1847.
16. Nielsen,B.S., Rank,F., Lopez,J.M., Balbin,M., Vizoso,F., Lund,L.R., Danø,K. and Lopez-Olin C. (2001) Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas. Cancer Res., 61, 7091-7100.
17. Chenard,M.P., Lutz,Y., Mechine-Neuville,A., Stoll,I., Bellocq,J.P., Rio,M.C. and Basset P. (1999) Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomas. Int. J. Cancer 82, 208-212.
18. Guy,C.T., Cardiff,R.D. and Muller,W.J. (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol. Cell. Biol., 12, 954-961.
19. Almholt,K., Lund,L.R., Rygaard,J., Nielsen,B.S., Danø,K., Rømer,J. and Johnsen,M. (2005) Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice. Int. J. Cancer, 113, 525-532.
20. Bugge,T.H., Lund,L.R., Kombrinck,K.K., Nielsen,B.S., Hohnback,K., Drew,A.F., Flick,M.J., Witte,D.P., Dano,K. and Degen,J.L. (1998) Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice. Oncogene, 16, 3097-3104.
21. Bonner,R.F., Emmert-Buck,M., Cole,K., Pohida,T., Chuaqui,R., Goldstein,S. and Liotta,L.A. (1997) Laser capture microdissection: molecular analysis of tissue. Science, 278, 1481-1483.
22. Simone,N.L., Bonner,R.F., Gillespie,J.W., Emmert-Buck,M.R. and Liotta,L.A. (1998) Laser-capture microdissection: Opening the microscopic frontier to molecular analysis. Trends Genet., 14 272-276.
23. Almholt,K., Nielsen,B.S., Frandsen,T.L., Brunner,N., Danø,K. and Johnsen,M. (2003) Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. Oncogene, 22, 4389-4397.
24. Pedersen,T.X., Leethanakul,C., Patel,V., Mitola,D., Lund,L.R., Danø,K., Johnsen,M., Gutkind,J.S. and Bugge,T.H. (2003) Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma. Oncogene, 22, 3964-3976.
25. Nuttall,R.K., Pennington,C.J., Taplin,J., Wheal,A., Yong,V.W., Forsyth,P.A. and Edwards,D.R. (2003) Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells. Mol. Cancer Res., 1, 333-345.
26. Lund,L.R., Rømer,J., Thomasset,N., Solberg,H., Pyke,C., Bissell,M.J., Danø,K. and Werb Z. (1996) Two distinct phases of apoptosis in mammary gland involution: Proteinase-independent and -dependent pathways. Development, 122, 181-193.
27. Lund,L.R., Rømer,J., Bugge,T.H., Nielsen,B.S., Frandsen,T.L., Degen,J.L., Stephens,R.W. and Danø,K. (1999) Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J., 18, 4645-4656.
28. Oberst,M., Anders,J., Xie,B., Singh,B., Ossandon,M., Johnson,M., Dickson,R.B. and Lin,C.Y. (2001) Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. Am. J. Pathol., 158, 1301-1311.
29. Lin,E.Y., Nguyen,A.V., Russell,R.G. and Pollard,J.W. (2001) Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med., 193, 727-740.
30. Desai,K.V., Xiao,N., Wang,W. et al. (2002) Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc. Natl Acad. Sci. USA, 99, 6967-6972.
31. Bianchi,E., Cohen,R.L., Dai,A., Thor,A.T., Shuman,M.A. and Smith,H.S. (1995) Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer. Int. J. Cancer, 60, 597-603.
32. Dalal,B.I., Keown,P.A. and Greenberg,A.H. (1993) Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am. J. Pathol., 143, 381-389.
33. Rønnov-Jessen,L. and Petersen,O.W. (1993) Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia. Lab. Invest., 68, 696-707.
34. Muraoka,R.S., Dumont,N., Ritter,C.A. et al. (2002) Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest., 109, 1551-1559.
35. Toole,B.P. (2003) Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function. Curr. Top. Dev. Biol., 54, 371-389.
36. Coussens,L.M., Tinkle,C.L., Hanahan,D. and Werb,Z. (2000) MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 103, 481-490.
37. Almholt,K. and Johnsen,M. (2003) Stromal cell involvement in cancer. Recent Results Cancer Res., 162, 31-42.