-
2
-
-
0037079071
-
Drug and gene delivery to the brain: The vascular route
-
PardridgeWM
-
PardridgeWM(2002) Drug and gene delivery to the brain: The vascular route. Neuron 36:555-558.
-
(2002)
Neuron
, vol.36
, pp. 555-558
-
-
-
3
-
-
34547637590
-
Drug targeting to the brain
-
Pardridge WM (2007) Drug targeting to the brain. Pharm Res 24:1733-1744.
-
(2007)
Pharm Res
, vol.24
, pp. 1733-1744
-
-
Pardridge, W.M.1
-
4
-
-
23644440809
-
Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route
-
Johanson CE, Duncan JA, Stopa EG, Baird A (2005) Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm Res 22: 1011-1037.
-
(2005)
Pharm Res
, vol.22
, pp. 1011-1037
-
-
Johanson, C.E.1
Duncan, J.A.2
Stopa, E.G.3
Baird, A.4
-
5
-
-
15944418259
-
The choroid plexus in the rise, fall and repair of the brain
-
Emerich DF, Skinner SJ, Borlongan CV, Vasconcellos AV, Thanos CG (2005) The choroid plexus in the rise, fall and repair of the brain. Bioessays 27:262-274.
-
(2005)
Bioessays
, vol.27
, pp. 262-274
-
-
Emerich, D.F.1
Skinner, S.J.2
Borlongan, C.V.3
Vasconcellos, A.V.4
Thanos, C.G.5
-
7
-
-
0035151602
-
Choroid plexus: Target for polypeptides and site of their synthesis
-
Chodobski A, Szmydynger-Chodobska J (2001) Choroid plexus: Target for polypeptides and site of their synthesis. Microsc Res Tech 52:65-82.
-
(2001)
Microsc Res Tech
, vol.52
, pp. 65-82
-
-
Chodobski, A.1
Szmydynger-Chodobska, J.2
-
8
-
-
0026720075
-
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
-
Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 5547-5551
-
-
Gossen, M.1
Bujard, H.2
-
9
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, et al. (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769.
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
-
10
-
-
0032498227
-
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
-
Mansuy IM, Mayford M, Jacob B, Kandel ER, Bach ME (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92:39-49.
-
(1998)
Cell
, vol.92
, pp. 39-49
-
-
Mansuy, I.M.1
Mayford, M.2
Jacob, B.3
Kandel, E.R.4
Bach, M.E.5
-
11
-
-
0028980154
-
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
-
Lovenberg TW, Chalmers DT, Liu C, De Souza EB (1995) CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology 136:4139-4142.
-
(1995)
Endocrinology
, vol.136
, pp. 4139-4142
-
-
Lovenberg, T.W.1
Chalmers, D.T.2
Liu, C.3
De Souza, E.B.4
-
12
-
-
13544277442
-
Mouse corticotropin-releasing factor receptor type 2alpha gene: Isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids
-
Chen A, et al. (2005) Mouse corticotropin-releasing factor receptor type 2alpha gene: Isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol 19:441-458.
-
(2005)
Mol Endocrinol
, vol.19
, pp. 441-458
-
-
Chen, A.1
-
13
-
-
0037341293
-
Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: Identification of multiple splice variants
-
Catalano RD, Kyriakou T, Chen J, Easton A, Hillhouse EW (2003) Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: Identification of multiple splice variants. Mol Endocrinol 17: 395-410.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 395-410
-
-
Catalano, R.D.1
Kyriakou, T.2
Chen, J.3
Easton, A.4
Hillhouse, E.W.5
-
14
-
-
0020008342
-
Post-translational proteolysis in polypeptide hormone biosynthesis
-
Docherty K, Steiner DF (1982) Post-translational proteolysis in polypeptide hormone biosynthesis. Annu Rev Physiol 44:625-638.
-
(1982)
Annu Rev Physiol
, vol.44
, pp. 625-638
-
-
Docherty, K.1
Steiner, D.F.2
-
15
-
-
0034143420
-
Do centrally administered neuropeptides access cognate receptors?: An analysis in the central corticotropin-releasing factor system
-
Bittencourt JC, Sawchenko PE (2000) Do centrally administered neuropeptides access cognate receptors?: An analysis in the central corticotropin-releasing factor system. J Neurosci 20:1142-1156.
-
(2000)
J Neurosci
, vol.20
, pp. 1142-1156
-
-
Bittencourt, J.C.1
Sawchenko, P.E.2
-
16
-
-
0022395472
-
-
Vickery BH (1985) Comparisons of the potential utility of LHRH agonists and antagonists for fertility control. J Steroid Biochem 23 (5B):779-791.
-
Vickery BH (1985) Comparisons of the potential utility of LHRH agonists and antagonists for fertility control. J Steroid Biochem 23 (5B):779-791.
-
-
-
-
17
-
-
0015820723
-
Production and characterization of an antiserum to synthetic gonadotropin-releasing hormone
-
Koch Y, et al. (1973) Production and characterization of an antiserum to synthetic gonadotropin-releasing hormone. Biochem Biophys Res Commun 55:616-622.
-
(1973)
Biochem Biophys Res Commun
, vol.55
, pp. 616-622
-
-
Koch, Y.1
-
18
-
-
0023035893
-
Transcriptional control of the mouse prealbumin (transthyretin) gene: Both promoter sequences and a distinct enhancer are cell specific
-
Costa RH, Lai E, Darnell JE, Jr. (1986) Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific. Mol Cell Biol 6:4697-4708.
-
(1986)
Mol Cell Biol
, vol.6
, pp. 4697-4708
-
-
Costa, R.H.1
Lai, E.2
Darnell Jr., J.E.3
-
19
-
-
54849431384
-
The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
-
Pickering C, et al. (2008) The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury. BMC Neurosci 9:97-110.
-
(2008)
BMC Neurosci
, vol.9
, pp. 97-110
-
-
Pickering, C.1
-
20
-
-
33846623795
-
Blood-brain barrier genomics
-
Pardridge WM (2007) Blood-brain barrier genomics. Stroke 38 (2, Suppl):686-690.
-
(2007)
Stroke
, vol.38
, Issue.2 and SUPPL.
, pp. 686-690
-
-
Pardridge, W.M.1
-
21
-
-
33845202060
-
The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells
-
Thouvenot E, et al. (2006) The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells. Proteomics 6: 5941-5952.
-
(2006)
Proteomics
, vol.6
, pp. 5941-5952
-
-
Thouvenot, E.1
-
23
-
-
0029993858
-
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
-
Naldini L, Blömer U, Gage FH, Trono D, Verma IM (1996) Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 93:11382-11388.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11382-11388
-
-
Naldini, L.1
Blömer, U.2
Gage, F.H.3
Trono, D.4
Verma, I.M.5
-
24
-
-
32944473438
-
Lentiviral vectors for use in the central nervous system
-
Jakobsson J, Lundberg C (2006) Lentiviral vectors for use in the central nervous system. Mol Ther 13:484-493.
-
(2006)
Mol Ther
, vol.13
, pp. 484-493
-
-
Jakobsson, J.1
Lundberg, C.2
-
25
-
-
0029996147
-
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
-
Naldini L, et al. (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
-
26
-
-
0018769324
-
A quantitative study of cell proliferation in ependyma and choroid plexus in the postnatal rat brain
-
Chauhan AN, Lewis PD (1979) A quantitative study of cell proliferation in ependyma and choroid plexus in the postnatal rat brain. Neuropathol Appl Neurobiol 5:303-309.
-
(1979)
Neuropathol Appl Neurobiol
, vol.5
, pp. 303-309
-
-
Chauhan, A.N.1
Lewis, P.D.2
-
27
-
-
34248679586
-
shRNA and siRNA delivery to the brain
-
Pardridge WM (2007) shRNA and siRNA delivery to the brain. Adv Drug Deliv Rev 59: 141-152.
-
(2007)
Adv Drug Deliv Rev
, vol.59
, pp. 141-152
-
-
Pardridge, W.M.1
-
28
-
-
34250665873
-
Targeted delivery of proteins across the blood-brain-barrier
-
Spencer BJ, Verma IM (2007) Targeted delivery of proteins across the blood-brain-barrier. Proc Natl Acad Sci USA 104:7594-7599.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7594-7599
-
-
Spencer, B.J.1
Verma, I.M.2
-
29
-
-
0033452452
-
Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
-
Seidah NG, Chrétien M (1999) Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides. Brain Res 848:45-62.
-
(1999)
Brain Res
, vol.848
, pp. 45-62
-
-
Seidah, N.G.1
Chrétien, M.2
-
30
-
-
19544393760
-
Cutting back on pro-protein convertases: The latest approaches to pharmacological inhibition
-
FugèreM, Day R (2005) Cutting back on pro-protein convertases: The latest approaches to pharmacological inhibition. Trends Pharmacol Sci 26:294-301.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 294-301
-
-
Fugère, M.1
Day, R.2
-
31
-
-
0027172072
-
Expression of neuropeptide processing enzymes and neurosecretory proteins in ependyma and choroid plexus epithelium
-
Gee P, Rhodes CH, Fricker LD, Angeletti RH (1993) Expression of neuropeptide processing enzymes and neurosecretory proteins in ependyma and choroid plexus epithelium. Brain Res 617:238-248.
-
(1993)
Brain Res
, vol.617
, pp. 238-248
-
-
Gee, P.1
Rhodes, C.H.2
Fricker, L.D.3
Angeletti, R.H.4
-
32
-
-
0025473187
-
Carboxypeptidase E (enkephalin convertase): MRNA distribution in rat brain by in situ hybridization
-
MacCumber MW, Snyder SH, Ross CA (1990) Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization. J Neurosci 10: 2850-2860.
-
(1990)
J Neurosci
, vol.10
, pp. 2850-2860
-
-
MacCumber, M.W.1
Snyder, S.H.2
Ross, C.A.3
-
33
-
-
0026591319
-
Expression of peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) in the rat central nervous system
-
Schafer MK, Stoffers DA, Eipper BA, Watson SJ (1992) Expression of peptidylglycine alpha-amidating monooxygenase (EC 1.14.17.3) in the rat central nervous system. J Neurosci 12:222-234.
-
(1992)
J Neurosci
, vol.12
, pp. 222-234
-
-
Schafer, M.K.1
Stoffers, D.A.2
Eipper, B.A.3
Watson, S.J.4
-
34
-
-
0027404880
-
Gene expression of prohormone and proprotein convertases in the rat CNS: A comparative in situ hybridization analysis
-
Schäfer MK, et al. (1993) Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis. J Neurosci 13:1258-1279.
-
(1993)
J Neurosci
, vol.13
, pp. 1258-1279
-
-
Schäfer, M.K.1
-
35
-
-
0023931764
-
Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain
-
Hynes MA, Brooks PJ, Van Wyk JJ, Lund PK (1988) Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain. Mol Endocrinol 2:47-54.
-
(1988)
Mol Endocrinol
, vol.2
, pp. 47-54
-
-
Hynes, M.A.1
Brooks, P.J.2
Van Wyk, J.J.3
Lund, P.K.4
-
36
-
-
0019782980
-
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin
-
Vale W, Spiess J, Rivier C, Rivier J (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 213:1394-1397.
-
(1981)
Science
, vol.213
, pp. 1394-1397
-
-
Vale, W.1
Spiess, J.2
Rivier, C.3
Rivier, J.4
-
37
-
-
0020627306
-
Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin
-
Rivier C, Vale W (1983) Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature 305:325-327.
-
(1983)
Nature
, vol.305
, pp. 325-327
-
-
Rivier, C.1
Vale, W.2
-
38
-
-
0020409215
-
Corticotropin releasing factor produces behavioural activation in rats
-
Sutton RE, Koob GF, Le Moal M, Rivier J, Vale WW (1982) Corticotropin releasing factor produces behavioural activation in rats. Nature 297:331-333.
-
(1982)
Nature
, vol.297
, pp. 331-333
-
-
Sutton, R.E.1
Koob, G.F.2
Le Moal, M.3
Rivier, J.4
Vale, W.W.5
-
39
-
-
0020183919
-
Corticotropin-releasing factor: Actions on the sympathetic nervous system and metabolism
-
Brown MR, et al. (1982) Corticotropin-releasing factor: Actions on the sympathetic nervous system and metabolism. Endocrinology 111:928-931.
-
(1982)
Endocrinology
, vol.111
, pp. 928-931
-
-
Brown, M.R.1
-
40
-
-
0033457357
-
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
-
Koob GF, Heinrichs SC (1999) A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Res 848:141-152.
-
(1999)
Brain Res
, vol.848
, pp. 141-152
-
-
Koob, G.F.1
Heinrichs, S.C.2
-
41
-
-
0032895726
-
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
-
Holsboer F (1999) The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 33:181-214.
-
(1999)
J Psychiatr Res
, vol.33
, pp. 181-214
-
-
Holsboer, F.1
-
42
-
-
0032899957
-
The role of corticotropin-releasing factor in depression and anxiety disorders
-
Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB (1999) The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 160:1-12.
-
(1999)
J Endocrinol
, vol.160
, pp. 1-12
-
-
Arborelius, L.1
Owens, M.J.2
Plotsky, P.M.3
Nemeroff, C.B.4
-
43
-
-
0242352560
-
Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
-
Holmes A, Heilig M, Rupniak NM, Steckler T, Griebel G (2003) Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders. Trends Pharmacol Sci 24:580-588.
-
(2003)
Trends Pharmacol Sci
, vol.24
, pp. 580-588
-
-
Holmes, A.1
Heilig, M.2
Rupniak, N.M.3
Steckler, T.4
Griebel, G.5
-
44
-
-
20344395876
-
Sensitivity to stress: Dysregulation of CRF pathways and disease development
-
Bale TL (2005) Sensitivity to stress: dysregulation of CRF pathways and disease development. Horm Behav 48:1-10.
-
(2005)
Horm Behav
, vol.48
, pp. 1-10
-
-
Bale, T.L.1
-
46
-
-
0032535291
-
Are different parts of the extended amygdala involved in fear versus anxiety?
-
Davis M (1998) Are different parts of the extended amygdala involved in fear versus anxiety? Biol Psychiatry 44:1239-1247.
-
(1998)
Biol Psychiatry
, vol.44
, pp. 1239-1247
-
-
Davis, M.1
-
47
-
-
0031854080
-
Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone
-
Griebel G, Perrault G, Sanger DJ (1998) Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone. Psychopharmacology (Berl) 138:55-66.
-
(1998)
Psychopharmacology (Berl)
, vol.138
, pp. 55-66
-
-
Griebel, G.1
Perrault, G.2
Sanger, D.J.3
-
48
-
-
0015208047
-
Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin
-
Amoss M, et al. (1971) Purification, amino acid composition and N-terminus of the hypothalamic luteinizing hormone releasing factor (LRF) of ovine origin. Biochem Biophys Res Commun 44:205-210.
-
(1971)
Biochem Biophys Res Commun
, vol.44
, pp. 205-210
-
-
Amoss, M.1
-
49
-
-
0015231127
-
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
-
Matsuo H, Baba Y, Nair RMG, Arimura A, Schally AV (1971) Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence. Biochem Biophys Res Commun 43:1334-1339.
-
(1971)
Biochem Biophys Res Commun
, vol.43
, pp. 1334-1339
-
-
Matsuo, H.1
Baba, Y.2
Nair, R.M.G.3
Arimura, A.4
Schally, A.V.5
-
50
-
-
0017130488
-
Localisation of gonadotropin-releasing and thyrotropin-releasing hormones in human brain by radioimmunoassay
-
Okon E, Koch Y (1976) Localisation of gonadotropin-releasing and thyrotropin-releasing hormones in human brain by radioimmunoassay. Nature 263:345-347.
-
(1976)
Nature
, vol.263
, pp. 345-347
-
-
Okon, E.1
Koch, Y.2
-
51
-
-
34250666701
-
Production and purification of lentiviral vectors
-
Tiscornia G, Singer O, Verma IM (2006) Production and purification of lentiviral vectors. Nat Protoc 1:241-245.
-
(2006)
Nat Protoc
, vol.1
, pp. 241-245
-
-
Tiscornia, G.1
Singer, O.2
Verma, I.M.3
-
52
-
-
33744995011
-
Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior
-
Chen A, et al. (2006) Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci 26:5500-5510.
-
(2006)
J Neurosci
, vol.26
, pp. 5500-5510
-
-
Chen, A.1
-
53
-
-
77950021602
-
Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits
-
10.1038/mp.2009.115
-
Neufeld-Cohen A, et al. (2009) Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol Psychiatry, 10.1038/mp.2009.115.
-
(2009)
Mol Psychiatry
-
-
Neufeld-Cohen, A.1
|