Transcription factor Sp1 expression is upregulated in human glomerulonephritis: Correlation with pSmad2/3 and p300 expression and renal injury

Renal Failure

Volumn 32, Issue 2, 2010, Pages 243-253

  Kassimatis, Theodoros Ioannis ^a   Nomikos, Alexandros ^b   Giannopoulou, Ioanna ^b   Lymperopoulos, Anastasios ^c   Moutzouris, Dimitrios Anestis ^a   Varakis, Ioannis ^d   Nakopoulou, Lydia ^b  

^a EVANGELISMOS HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF PATRAS   (Greece)

Author keywords

Glomerulonephritis; P300; PSmad23; Renal fibrosis; Sp1

Indexed keywords

CREATININE; PHOSPHOPROTEIN; PROTEIN P300; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SP1;

ADULT; ARTICLE; CELL HYPERPLASIA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; FOCAL GLOMERULOSCLEROSIS; GLOMERULONEPHRITIS; GLOMERULUS; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; INFECTION COMPLICATION; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; PAUCIIMMUNE GLOMERULONEPHRITIS; POSTINFECTIOUS GLOMERULONEPHRITIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN PROTEIN INTERACTION; UPREGULATION;

ADULT; BIOPSY; CHI-SQUARE DISTRIBUTION; E1A-ASSOCIATED P300 PROTEIN; FEMALE; GLOMERULONEPHRITIS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SP1 TRANSCRIPTION FACTOR; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 77749288944     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/08860220903411164     Document Type: Article

References (36)

1. Sporn MB, Roberts AB. Transforming growth factor-beta: Recent progress and new challenges. J Cell Biol. 1992;119:1017-1021.
2. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med. 1994;331:1286-1292.
3. Border WA, Noble NA. TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int. 1997;51:1388-1396.
4. Yamamoto T, Noble NA, Cohen AH, et al. Expression of transforming growth factor-beta isoforms in human glomerular diseases. Kidney Int. 1996;49:461-469.
5. Massague J. TGF-beta signal transduction. Annu Rev Biochem. 1998;67:753-791.
6. Wrana JL, Attisano L, Wieser R, Ventura F, Massague J. Mechanism of activation of the TGF-beta receptor. Nature. 1994;370:341-347.
7. Nakao A, Imamura T, Souchelnytskyi S, et al. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. Embo J. 1997;16:5353-5362.
8. Miyazono K, ten Dijke P, Heldin CH. TGF-beta signaling by Smad proteins. Adv Immunol. 2000;75:115-157.
9. Macias-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell. 1996;87:1215-1224.
10. Zhang Y, Feng X, We R, Derynck R. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 1996;383:168-172.
11. Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. Embo J. 1998;17:3091-3100.
12. Zawel L, Dai JL, Buckhaults P, et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998;1:611-617.
13. Massague J, Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. Embo J. 2000;19:1745-1754.
14. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685-700.
15. de Caestecker MP, Yahata T, Wang D, et al. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcrip-tional activation domain. J Biol Chem. 2000;275:2115-2122.
16. Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF. TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol Biol Cell. 1998;9:3309-3319.
17. Kassimatis TI, Giannopoulou I, Koumoundourou D, Theodorakopoulou E, Varakis I, Nakopoulou L. Immunohis-tochemical evaluation of phosphorylated SMAD2/SMAD3 and the co-activator P300 in human glomerulonephritis: Correlation with renal injury. J Cell Mol Med. 2006;10:908-921.
18. Kanamaru Y, Nakao A, Tanaka Y, et al. Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol. 2003;95:e36-e42.
19. Suske G. The Sp-family of transcription factors. Gene. 1999;238:291-300.
20. Datta PK, Blake MC, Moses HL. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta-induced physical and functional interactions between Smads and Sp1. J Biol Chem. 2000;275:40014-40019.
21. Poncelet AC, Schnaper HW. Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem. 2001;276:6983-6992.
22. Inagaki Y, Nemoto T, Nakao A, et al. Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription. J Biol Chem, 2001;276:16573-16579.
23. Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription. J Biol Chem. 2000;275:39237-39245.
24. Pardali K, Kurisaki A, Moren A, ten Dijke P., Kardassis D, Moustakas A. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. J Biol Chem. 2000;275:29244-29256.
25. Wu Y, Zhang X, Salmon M, Lin X, Zehner ZE. TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members. Biochim Biophys Acta. 2007;1773:427-439.
26. Ihn H, Yamane K, Asano Y, Jinnin M, Tamaki K. Constitu-tively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts. Rheumatology (Oxford). 2006;45: 157-165.
27. Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K. Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1. Oncogene. 2004;23:1656-1667.
28. Bussolati G, Gugliotta P, Volante M, Pace M, Papotti M. Retrieved endogenous biotin: a novel marker and a potential pitfall in diagnostic immunohistochemistry. Histopathology. 1997;31:400-407.
29. Wang L, Wei D, Huang S, et al. Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. Clin Cancer Res. 2003;9:6371-6380.
30. Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP. Sp1 is a critical regulator of the Wilms' tumor-1 gene. J Biol Chem. 1997;272:2901-2913.
31. Wang L, Guan X, Gong W, et al. Altered expression of transcription factor Sp1 critically impacts the angiogenic pheno-type of human gastric cancer. Clin Exp Metastasis. 2005;22:205-213.
32. Abdelrahim M, Liu S, Safe S. Induction of endoplasmic reticulum-induced stress genes in Panc-1 pancreatic cancer cells is dependent on Sp proteins. J Biol Chem. 2005;280: 16508-16513.
33. Gu L, Ni Z, Qian J, Tomino Y. Pravastatin inhibits car-boxymethyllysine- induced monocyte chemoattractant protein 1 expression in podocytes via prevention of signalling events. Nephron Exp Nephrol. 2007;106:e1-e10.
34. Chen G, Wang D, Vikramadithyan R, et al. Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression. Biochemistry. 2004;43:4971-4977.
35. Chen Y, Currie RW. Heat shock treatment suppresses angio-tensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. Inflamm Res. 2005;54:338-343.
36. Meissner M, Stein M, Urbich C, et al. PPARalpha activators inhibit vascular endothelial growth factor receptor-2 expression by repressing Sp1-dependent DNA binding and transac-tivation. Circ Res. 2004;94:324-332.