-
1
-
-
53949092147
-
Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics
-
Tao YX (2008) Constitutive activation of G protein-coupled receptors and diseases: Insights into mechanisms of activation and therapeutics. Pharmacol Ther 120:129-148.
-
(2008)
Pharmacol Ther
, vol.120
, pp. 129-148
-
-
Tao, Y.X.1
-
2
-
-
31844446495
-
Recent developments in constitutive receptor activity and inverse agonism, and theirpotential forGPCR drug discovery
-
Bond RA, Ijzerman AP (2006) Recent developments in constitutive receptor activity and inverse agonism, and theirpotential forGPCR drug discovery. Trends Pharmacol Sci 27:92-96.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 92-96
-
-
Bond, R.A.1
Ijzerman, A.P.2
-
3
-
-
0036033424
-
Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
-
Seifert R, Wenzel-Seifert K (2002) Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn Schmiedebergs Arch Pharmacol 366:381-416.
-
(2002)
Naunyn Schmiedebergs Arch Pharmacol
, vol.366
, pp. 381-416
-
-
Seifert, R.1
Wenzel-Seifert, K.2
-
4
-
-
58849083853
-
Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: The GnRH receptor
-
Janovick JA, et al. (2009) Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: The GnRH receptor. Mol Endocrinol 23:157-168.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 157-168
-
-
Janovick, J.A.1
-
5
-
-
0034682639
-
Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction
-
Flanagan CA, et al. (2000) Multiple interactions of the Asp(2.61(98)) side chain of the gonadotropin-releasing hormone receptor contribute differentially to ligand interaction. Biochemistry 39:8133-8141.
-
(2000)
Biochemistry
, vol.39
, pp. 8133-8141
-
-
Flanagan, C.A.1
-
6
-
-
0029135443
-
A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites
-
Zhou W, et al. (1995) A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites. J Biol Chem 270:18853-18857.
-
(1995)
J Biol Chem
, vol.270
, pp. 18853-18857
-
-
Zhou, W.1
-
7
-
-
0035919721
-
Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp(90) residue
-
Blomenröhr M, et al. (2001) Proper receptor signalling in a mutant catfish gonadotropin-releasing hormone receptor lacking the highly conserved Asp(90) residue. FEBS Lett 501:131-134.
-
(2001)
FEBS Lett
, vol.501
, pp. 131-134
-
-
Blomenröhr, M.1
-
8
-
-
0036090269
-
Molecular basis of hypogonadotropic hypogonadism: Restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site
-
Maya-Núñez G, et al. (2002) Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. J Clin Endocrinol Metab 87:2144-2149.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2144-2149
-
-
Maya-Núñez, G.1
-
9
-
-
3042800569
-
Human loss-of-function gonadotropinreleasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: Molecular basis of the dominant-negative effect
-
Brothers SP, Cornea A, Janovick JA, Conn PM(2004) Human loss-of-function gonadotropinreleasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: Molecular basis of the dominant-negative effect. Mol Endocrinol 18:1787-1797.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1787-1797
-
-
Brothers, S.P.1
Cornea, A.2
Janovick, J.A.3
Conn, P.M.4
-
10
-
-
34250172768
-
Refolding of misfolded mutant GPCR: Post-translational pharmacoperone action in vitro
-
Janovick JA, et al. (2007) Refolding of misfolded mutant GPCR: Post-translational pharmacoperone action in vitro. Mol Cell Endocrinol 272:77-85.
-
(2007)
Mol Cell Endocrinol
, vol.272
, pp. 77-85
-
-
Janovick, J.A.1
-
11
-
-
65349135370
-
Drug development and the cellular quality control system
-
Conn PM, Janovick JA (2009) Drug development and the cellular quality control system. Trends Pharmacol Sci 30:228-233.
-
(2009)
Trends Pharmacol Sci
, vol.30
, pp. 228-233
-
-
Conn, P.M.1
Janovick, J.A.2
-
12
-
-
0344059035
-
Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor
-
Janovick JA, et al. (2003) Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor. J Pharmacol Exp Ther 305:608-614.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 608-614
-
-
Janovick, J.A.1
-
13
-
-
0036322898
-
Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific proteinfolding template: Misrouted proteins as a novel disease etiology and therapeutic target
-
Janovick JA, Maya-Nunez G, Conn PM (2002) Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific proteinfolding template: Misrouted proteins as a novel disease etiology and therapeutic target. J Clin Endocrinol Metab 87:3255-3262.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 3255-3262
-
-
Janovick, J.A.1
Maya-Nunez, G.2
Conn, P.M.3
-
14
-
-
0036774528
-
Receptor-misrouting: An unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism
-
Leaños-Miranda A, Janovick JA, Conn PM (2002) Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism. J Clin Endocrinol Metab 87:4825-4828.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4825-4828
-
-
Leaños-Miranda, A.1
Janovick, J.A.2
Conn, P.M.3
-
15
-
-
18844451476
-
In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadisminhumans expressing compound heterozygous alleles
-
Leaños-MirandaA, Ulloa-Aguirre A, Janovick JA, ConnPM(2005) In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadisminhumans expressing compound heterozygous alleles. J Clin Endocrinol Metab 90:3001-3008.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 3001-3008
-
-
MirandaA, L.1
Ulloa-Aguirre, A.2
Janovick, J.A.3
ConnPM4
-
16
-
-
0038637206
-
Dominantnegative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: A trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans
-
Leaños-Miranda A, Ulloa-Aguirre A, Ji TH, Janovick JA, Conn PM (2003) Dominantnegative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. J Clin Endocrinol Metab 88:3360-3367.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3360-3367
-
-
Leaños-Miranda, A.1
Ulloa-Aguirre, A.2
Ji, T.H.3
Janovick, J.A.4
Conn, P.M.5
-
17
-
-
33646849270
-
Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: Molecular basis of an evolved strategy
-
Janovick JA, et al. (2006) Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. J Biol Chem 281:8417-8425.
-
(2006)
J Biol Chem
, vol.281
, pp. 8417-8425
-
-
Janovick, J.A.1
-
18
-
-
77749322226
-
-
eds Lederis K, Cooper KE Karger, Calgary, pp
-
Grant G, et al. (1973) Recent Studies of Hypothalamic Function Int. Symp, eds Lederis K, Cooper KE (Karger, Calgary), pp 180-195.
-
(1973)
Recent Studies of Hypothalamic Function Int. Symp
, pp. 180-195
-
-
Grant, G.1
-
19
-
-
58649112159
-
Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease
-
Conn PM, Janovick JA (2009) Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease. Mol Cell Endocrinol 299:137-145.
-
(2009)
Mol Cell Endocrinol
, vol.299
, pp. 137-145
-
-
Conn, P.M.1
Janovick, J.A.2
-
20
-
-
0001169515
-
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
-
Costa T, Herz A (1989) Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. Proc Natl Acad Sci USA 86:7321-7325.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 7321-7325
-
-
Costa, T.1
Herz, A.2
-
21
-
-
0347362854
-
Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: Implications for understanding the molecular etiology of hypogonadotropic hypogonadism
-
Brothers SP, Janovick JA, Conn PM (2003) Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. J Clin Endocrinol Metab 88:6107-6112.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 6107-6112
-
-
Brothers, S.P.1
Janovick, J.A.2
Conn, P.M.3
-
22
-
-
0031465316
-
Inverse agonism and the regulation of receptor number
-
Milligan G, Bond RA (1997) Inverse agonism and the regulation of receptor number. Trends Pharmacol Sci 18:468-474.
-
(1997)
Trends Pharmacol Sci
, vol.18
, pp. 468-474
-
-
Milligan, G.1
Bond, R.A.2
-
23
-
-
0023161268
-
Use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover
-
Huckle WR, Conn PM (1987) Use of lithium ion in measurement of stimulated pituitary inositol phospholipid turnover. Methods Enzymol 141:149-155.
-
(1987)
Methods Enzymol
, vol.141
, pp. 149-155
-
-
Huckle, W.R.1
Conn, P.M.2
-
24
-
-
0000401592
-
Protein origami: Therapeutic rescue of misfolded gene products
-
Conn PM, Leaños-Miranda A, Janovick JA (2002) Protein origami: Therapeutic rescue of misfolded gene products. Mol Interv 2:308-316.
-
(2002)
Mol Interv
, vol.2
, pp. 308-316
-
-
Conn, P.M.1
Leaños-Miranda, A.2
Janovick, J.A.3
-
25
-
-
7244253015
-
Pharmacologic rescue of conformationally-defective proteins: Implications for the treatment of human disease
-
Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM (2004) Pharmacologic rescue of conformationally-defective proteins: Implications for the treatment of human disease. Traffic 5:821-837.
-
(2004)
Traffic
, vol.5
, pp. 821-837
-
-
Ulloa-Aguirre, A.1
Janovick, J.A.2
Brothers, S.P.3
Conn, P.M.4
-
26
-
-
21644476127
-
Beyond the signal sequence: Protein routing in health and disease
-
Castro-Fernández C, Maya-Núñez G, Conn PM (2005) Beyond the signal sequence: protein routing in health and disease. Endocr Rev 26:479-503.
-
(2005)
Endocr Rev
, vol.26
, pp. 479-503
-
-
Castro-Fernández, C.1
Maya-Núñez, G.2
Conn, P.M.3
-
27
-
-
0030917971
-
An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation
-
Cook JV, Eidne KA (1997) An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation. Endocrinology 138:2800-2806.
-
(1997)
Endocrinology
, vol.138
, pp. 2800-2806
-
-
Cook, J.V.1
Eidne, K.A.2
-
28
-
-
21644456254
-
Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropinreleasing hormone receptor mutants
-
Knollman PE, Janovick JA, Brothers SP, Conn PM (2005) Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropinreleasing hormone receptor mutants. J Biol Chem 280:24506-24514.
-
(2005)
J Biol Chem
, vol.280
, pp. 24506-24514
-
-
Knollman, P.E.1
Janovick, J.A.2
Brothers, S.P.3
Conn, P.M.4
-
29
-
-
0842313243
-
Evolved regulation of gonadotropinreleasing hormone receptor cell surface expression
-
Janovick JA, Ulloa-Aguirre A, Conn PM (2003) Evolved regulation of gonadotropinreleasing hormone receptor cell surface expression. Endocrine 22:317-327.
-
(2003)
Endocrine
, vol.22
, pp. 317-327
-
-
Janovick, J.A.1
Ulloa-Aguirre, A.2
Conn, P.M.3
-
30
-
-
0242500958
-
Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: The case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance
-
Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM (2003) Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance. Expert Opin Ther Targets 7:175-185.
-
(2003)
Expert Opin Ther Targets
, vol.7
, pp. 175-185
-
-
Ulloa-Aguirre, A.1
Janovick, J.A.2
Leaños-Miranda, A.3
Conn, P.M.4
-
31
-
-
0037171443
-
Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization
-
Brothers SP, et al. (2002) Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization.Mol Cell Endocrinol 190:19-27.
-
(2002)
Mol Cell Endocrinol
, vol.190
, pp. 19-27
-
-
Brothers, S.P.1
|