Immunohistochemical study of p16INK4A and survivin expressions in cervical squamous neoplasm

Indian Journal of Pathology and Microbiology

Volumn 53, Issue 1, 2010, Pages 1-6

  Tan, Geok Tan ^a   Norlatiffah, Sydee ^a   Sharifah, N Akmal ^a   Razmin, Ghazali ^b   Shiran, M Sikik ^c   Hatta, A Zailani ^a   Paul Ng, H Oon ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b HOSPITAL KUALA LUMPUR   (Malaysia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Cervical cancer; Cervix; Immunohistochemistry; P16; Survivin

Indexed keywords

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR 2A; SURVIVIN;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER PATIENT; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PREDICTION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALAYSIA; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; TUMOR MARKERS, BIOLOGICAL; UTERINE NEOPLASMS; YOUNG ADULT;

EID: 77749261735     PISSN: 03774929     EISSN: 09745130     Source Type: Journal    
DOI: 10.4103/0377-4929.59173     Document Type: Article

References (36)

1. Yahya H and Lim G. Second Report of the National Cancer Registry Cancer Incidence in Malaysia: Ministry of Health Malaysia. 2003
2. Wright TC Jr, Cox JT, Massad LS, Carlson J, Twiggs LB, Wilkinson EJ, et al. 2001 Consensus Guidelines for the Management of Women with Cervical Intraepithelial Neoplasia. J Low Genit Tract Dis 2003;7:154-67.
3. Spitzer M. Cervical screening adjuncts: recent advances. Am J Obstet Gynecol 1998;179:544-56.
4. INK4a immunoexpression: surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia. Adv Anat Pathol 2006;13:190-4.
5. Lee JP, Chang KH, Han JH, Ryu HS. Survivin, a novel anti-apoptosis inhibitor, expression in uterine cervical cancer and relationship with prognostic factors. Int J Gynecol Cancer 2005;15:113-9.
6. Borbély AA, Murvai M, Ḱnya J, Beck Z, Gergely L, Li F, et al. Effects of human papillomavirus type 16 oncoproteins on survivin gene expression. J Gen Virol 2006;87:287-94.
7. (INK4a) expression correlates with degree of cervical neoplasia: a comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 2003;16:665-73.
8. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276-84.
9. Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T. Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 1998;153:1741-8.
10. INK4a Immunocytochemistry as a Triage Test for Liquid-based Cervicovaginal Cytology Samples Diagnosed as High-Grade Squamous Intrepithelial Lesions. Pathology Case Reviews 2005;10:144-9.
11. de Villiers EM. Taxonomic classification of papillomaviruses. Papillomavirus Report 2001;12:57-63.
12. Mantovani F, Banks L. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 2001;20:7874-87.
13. Gaarenstroom KN, Melkert P, Walboomers JM, Van Den Brule AJ, Van Bommel PF, Meyer CJ, et al. Human papillomavirus DNA and genotypes: prognostic factors for progression of cervical intraepithelial neoplasia. Int J Gynecol Cancer 1994;4:73-8.
14. Münger K, Basile JR, Duensing S, Eichten A, Gonzalez SL, Grace M, et al. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 2001;20:7888-98.
15. Flores ER, Allen-Hoffmann BL, Lee D, Lambert PF. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J Virol 2000;74:6622-31.
16. Tommasino M. Early genes of human papillomaviruses. Encyclopedic reference of cancer. Springer-Verlag 2001. p. 266-72.
17. INK4a-imposed G1 cell cycle Arrest. J Virol 2001;75:4705-12.
18. Branca M, Ciotti M, Santini D, Di Bonito L, Giorgi C, Benedetto A, et al. p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome. Int J Gynecol Pathol 2004;23:354-65.
19. INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. J Clin Pathol 2005;58:525-34.
20. INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol 2005;18:267-73.
21. Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998;396:580-4.
22. (Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix. Arch Pathol Lab Med 2008;132:795-9.
23. Cruez AF. Malaysian youth are involved in sexual activities before the age of 20-Lekhraj Rampal New Straits Times: Press Holding Ltd. Co., 2007
24. INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia. Int J Gynecol Cancer 2006;16:347-53.
25. Ostör AG. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol 1993;12:186-92.
26. Elfgren K, Kalantari M, Moberger B, Hagmar B, Dillner J. A population-based five-year follow-up study of cervical human papillomavirus infection. Am J Obstet Gynecol 2000;183:561-7.
27. Dalstein V, Riethmuller D, Prétet JL, Le Bail Carval K, Sautière JL, Carbillet JP, et al. Persistence and load of high-risk HPV are predictors for development of high-grade cervical lesions: a longitudinal French cohort study. Int J Cancer 2003;106:396-403.
28. Schlecht NF, Kulaga S, Robitaille J, Ferreira S, Santos M, Miyamura RA, et al. Persistent human papillomavirus infection as a predictor of cervical intraepithelial neoplasia. JAMA 2001;286:3106-14.
29. Nieh S, Chen SF, Chu TY, Lai HC, Lin YS, Fu E, et al. Is p16(INK4A) expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear? A comparative analysis using abnormal cervical smears with follow-up biopsies. Gynecol Oncol 2005;97:35-40.
30. INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus. J Pathol 2003;201:109-18.
31. Branca M, Giorgi C, Santini D, Di Bonito L, Ciotti M, Costa S, et al. HPV-Pathogen ISS Study Group. Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer. Am J Clin Pathol 2005;124:113-21
32. INK4a: is there a correlation with lesion grade or high-risk human papilloma virus positivity? J Obstet Gynaecol Res 2008;34:865-71.
33. Saitoh Y, Yaginuma Y, Ishikawa M. Analysis of Bcl-2, Bax and Survivin genes in uterine cancer. Int J Oncol 1999;15:137-41.
34. Chiodino C, Cesinaro AM, Ottani D, Fantini F, Giannetti A, Trentini GP, Pincelli C. Communication: expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin. J Invest Dermatol 1999;113:415-8.
35. Frost M, Jarboe EA, Orlicky D, Gianani R, Thompson LC, Enomoto T, et al. Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia, and invasive squamous cell carcinoma. Am J Clin Pathol 2002;117:738-44.
36. Branca M, Ciotti M, Giorgi C, Santini D, Di Bonito L, Costa S, et al. HPV-Pathogen ISS Study Group. Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling. Int J Gynecol Pathol 2008;27:265-73.