2001 consensus guidelines for the management of women with cervical intraepithelial neoplasia

Journal of Lower Genital Tract Disease

Volumn 7, Issue 3, 2003, Pages 154-167

  Wright Jr , Thomas C ^a   Cox, J Thomas ^b,c   Massad, L Stewart ^d   Carlson, Jay ^e   Twiggs, Leo B ^f   Wilkinson, Edward J ^g  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c American Social Health Association   (United States)

^d SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e WALTER REED ARMY MEDICAL CENTER   (United States)

^f UNIVERSITY OF MIAMI   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; PODOPHYLLIN;

AGE; CANCER GROWTH; CANCER RECURRENCE; CANCER SURGERY; CLINICAL PRACTICE; COLPOSCOPY; CRYOTHERAPY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DISEASE PREDISPOSITION; DISEASE SEVERITY; ELECTROSURGERY; EVIDENCE BASED MEDICINE; FOLLOW UP; GYNECOLOGIC DISEASE; HEALTH CARE ORGANIZATION; HISTOLOGY; HUMAN; HYSTERECTOMY; IMMUNE DEFICIENCY; LASER SURGERY; MEDICAL DECISION MAKING; MICROBIOLOGICAL EXAMINATION; PAPILLOMA VIRUS; PRACTICE GUIDELINE; PREGNANCY; REVIEW; RISK ASSESSMENT; SURGICAL TECHNIQUE; TREATMENT OUTCOME; TREATMENT PLANNING; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU;

EID: 0042122554     PISSN: 10892591     EISSN: None     Source Type: Journal    
DOI: 10.1097/00128360-200307000-00002     Document Type: Review

References (90)

1. Jones BA, Davey DD. Quality management in gynecologic cytology using interlaboratory comparison. Arch Pathol Lab Med 2000;124:672-81.
2. Wright TC Jr., Cox JT, Massad LS, Twiggs LB, Wilkinson EJ. 2001 Consensus Guidelines for the management of women with cervical cytological abnormalities. JAMA 2002;287:2120-9.
3. USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with HIV. MMWR 1999;48(No. RR-10):1-26.
4. Kish MA. Guide to development of practice guidelines. Clin Infect Dis 2001;32:851-4.
5. Robertson AJ, Anderson JM, Beck JS, Burnett RA, Howatson SR, Lee FD, et al. Observer variability in histopathological reporting of cervical biopsy specimens. J Clin Pathol 1989;42:231-8.
6. Ismail SM, Colelough AB, Dinnen JS, Eakins D, Evans DM, Gradwell E, et al. Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. BMJ 1989;298:707-10.
7. Stoler MH, Schiffman M. Interobserver reproducibility of cervical cytologic and histologic interpretations: Realistic estimates from the ASCUS-LSIL Triage Study. JAMA 2001;285:1500-5.
8. Massad LS, Halperin CJ, Bitterman P. Correlation between colposcopically directed biopsy and cervical loop excision. Gynecol Oncol 1996;60:400-3.
9. Ostor AG. Natural history of cervical intraepithelial neoplasia: A critical review. Int J Gynecol Pathol 1993;12:186-92.
10. Melnikow J, Nuovo J, Willan AR, Chan BK, Howell LP. Natural history of cervical squamous intraepithelial lesions: A meta-analysis. Obstet Gynecol 1998;92:727-35.
11. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276-84.
12. Connolly DC, Greenspan DL, Wu R, Ren X, Dunn RL, Shah KV, et al. Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease. Clin Cancer Res 2000;6:3505-10.
13. Lin WM, Michalopulos EA, Dhurander N, Cheng PC, Robinson W, Ashfaq R, et al. Allelic loss and microsatellite alterations of chromosome 3p14.2 are more frequent in recurrent cervical dysplasias. Clin Cancer Res 2000;6:1410-4.
14. Bibbo M, Dytch HE, Alenghat E, Bartels PH, Wied GL. DNA ploidy profiles as prognostic indicators in CIN lesions. Am J Clin Pathol 1989;92:261-5.
15. Wisman GB, De Jong S, Meersma GJ, Helder MN, Hollema H, De Vries EG, et al. Telomerase in (pre)neoplastic cervical disease. Hum Pathol 2000;31:1304-12.
16. Fu YS, Reagan J, Richart RM. Definition of precursors. Gynecol Oncol 1981;12:s220.
17. Shafi MI, Luesley DM, Jordan JA, Dunn JA, Rollason TP, Yates M. Randomised trial of immediate versus deferred treatment strategies for the management of minor cervical cytological abnormalities. Br J Obstet Gynaecol 1997;104:590-4.
18. Cannistra SA, Niloff JM. Cancer of the uterine cervix. N Engl J Med 1996;334:1030-8.
19. Nasiell K, Roger V, Nasiell M. Behavior of mild cervical dysplasia during long-term follow-up. Obstet Gynecol 1986;67:665-9.
20. Luthra UK, Prabhakar AK, Seth P, Agarwal SS, Murthy NS, Bhatnagar P, et al. Natural history of precancerous and early cancerous lesions of the uterine cervix. Acta Cytol 1987;31:226-34.
21. Robertson JH, Woodend BE, Crozier EH, Hutchinson J. Risk of cervical cancer associated with mild dyskaryosis. BMJ 1988;297:18-21.
22. Weaver MG, Abdul-Karim FW, Dale G, Sorensen K, Huang YT. Outcome in mild and moderate cervical dysplasias related to the presence of specific human papillomavirus types. Mod Pathol 1990;3:679-83.
23. Solomon D, Schiffman M, Tarrone R. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: Baseline results from a randomized trial. J Natl Cancer Inst 2001;93:293-9.
24. Manos MM, Kinney WK, Hurley LB, Sherman ME, Shieh-Ngai J, Kurman RJ, et al. Identifying women with cervical neoplasia: Using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA 1999;281:1605-10.
25. Wright TC, Sun XW, Koulos J. Comparison of management algorithms for the evaluation of women with low-grade cytologic abnormalities. Obstet Gynecol 1995;85:202-10.
26. Guido R, Solomon D, Schiffman M, Burke L. Comparison of management strategies for women diagnosed as CIN 1 or less, postcolposcopic evaluation: Data from the ASCUS and LSIL Triage Study (ALTS), a Multicenter Randomized Trial. J Lower Gen Tract Dis 2002;6:176.
27. Nobbenhuis MA, Walboomers JM, Helmerhorst TJ, Rozendaal L, Remmink AJ, Risse EK, et al. Relation of human papillomavirus status to cervical lesions and consequences for cervical-cancer screening: A prospective study. Lancet 1999;354:20-5.
28. Holowaty P, Miller AB, Rohan T, To T. Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst 1999;91:252-8.
29. Spitzer M, Chernys AE, Shifrin A, Ryskin M. Indications for cone biopsy: Pathologic correlation. Am J Obstet Gynecol 1998;178:74-9.
30. Shafi MI, Luesley DM. Management of low grade lesions: Follow-up or treat? Baillieres Clin Obstet Gynaecol 1995;9:121-31.
31. Richart RM, Wright TC. Controversies in the management of low grade cervical intraepithelial neoplasia. Cancer 1993;71:1413-21.
32. Fine BA, Feinstein GI, Sabella V. The pre- and post-operative value of endocervical curettage in the detection of cervical intraepithelial neoplasia and invasive cervical cancer. Gynecol Oncol 1998;71:46-9.
33. Hatch KD, Shingleton HM, Orr JW Jr., Gore H, Soong SJ. Role of endocervical currettage in colposcopy. Obstet Gynecol 1985;65:403-8.
34. Sevin B-U, Ford JH, Girtanner Rd, Hoskins WJ, Ng ABP, Nordqvist SRB, et al. Invasive cancer of the cervix after cryosurgery. Pitfalls of conservative management. Obst Gynecol 1979;53:465-71.
35. Townsend DE, Richart RM, Marks E, Nielsen J. Invasive cancer following outpatient evaluation and therapy for cervical disease. Obstet Gynecol 1981;57:145-9.
36. Schmidt C, Pretorius RG, Bonin M, Hanson L, Semrad N, Watring W. Invasive cervical cancer following cryotherapy for cervical intraepithelial neoplasia or human papillomavirus infection. Obstet Gynecol 1992;80:797-800.
37. Singer A, Monaghan JM. Lower Genital Tract Precancer: Colposcopy, Pathology and Treatment. London: Blackwell Scientific Publications; 1994.
38. Lopes A, Mor-Yosef S, Pearson S, Ireland D, Monaghan JM. Is routine colposcopic assessment necessary following laser ablation of cervical intraepithelial neoplasia? Br J Obstet Gynaecol 1990;97:175-7.
39. Cullimore J, Woodman CB, Luesley DM, Jordan JA, Byrne P. When laser vaporisation for CIN fails, what next? Lancet 1989;8646:1081-2.
40. Murdoch JB, Morgan PR, Lopes A, Monaghan JM. Histological incomplete excision of CIN after large loop excision of the the transformation zone (LLETZ) merits careful follow up, not retreatment. Br J Obstet Gynaecol 1992;99:990-3.
41. Paraskevaidis E, Jandial L, Mann EMF, Fisher PM, Kitchener HC. Pattern of treatment failure following laser for cervical intraepithelial neoplasia: Implications for follow-up protocol. Obstet Gynecol 1991;78:80-3.
42. Mithell MF, Tortolero-Luna G, Cook E, Whittaker L, Rhodes-Morris H, Silva E. A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intrapithelial lesions of the cervix. Obstet Gynecol 1998;92:737-44.
43. Alvarez RD, Helm CW, Edwards RP, Naumann RW, Partridge EE, Shingleton HM, et al. Prospective randomied trial of LLETZ versus laser ablation in patients with cervical intraepithelial neoplasia. Gynecol Oncol 1994;52:175-9.
44. Ferenczy A. Comparison of cryo- and carbon dioxide laser therapy for cervical intraepithelial neoplasia. Obstet Gynecol 1985;66:793-8.
45. Nuovo J, Melnikow J, Willan AR, Chan BK. Treatment outcomes for squamous intraepithalial lesions. Int J Gynaecol Obstet 2000;68:25-33.
46. Oyesanya O, Amerasinghe C, Manning EAD. A comparison between loop diathermy conization and cold-knife conization for management of cervical dysplasia associated with unsatisfactory colposcopy. Gynecol Oncol 1993;50:84-8.
47. Girardi F, Heydarfadai M, Koroschetz F, Pickel H, Winter R. Cold-knife conization versus loop excision: Histopathologic and clinical results of a randomized trial. Gynecol Oncol 1994;55:368-70.
48. Giacalone PL, Laffargue F, Aligier N, Roger P, Combecal J, Daures JP. Randomized study comparing two techniques of conization: Cold knife versus loop excision. Gynecol Oncol 1999;75:356-60.
49. Wright TC, Ferenzcy AF, Kurman RJ. Precancerous lesions of the cervix. In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. New York: Springer-Verlag; 2002:253-324.
50. Mitchell MF, Tortolero-Luna G, Wright T, Sarkar A, Richards-Kortum R, Hong WK, et al. Cervical human papillomavirus infection and intraepithelial neoplasia: A review. J Natl Cancer Inst Monogr 1996;21:17-25
51. Genest DR, Stein L, Cibas E, Sheets E, Zitz JC, Crum CP. A binary (Bethesda) system for classifying cervical cancer precursors: Criteria, reproducibility, and viral correlates. Hum Pathol 1992;24:730-6.
52. Bjerre B, Eliasson G, Linell F, Soderberg H, Sjoberg NO. Conization as only treatment of carcinoma in situ of the uterine cervix. Am J Obstet Gynecol 1976;125:143-52.
53. Burke L, Covell L, Antonioli D. Carbon dioxide laser therapy of cervical intraepithelial neoplasia: Factors determining success rate. Lasers Surg Med 1980;1:113-22.
54. Pearson SE, Whittaker J, Ireland D, Monaghan JM. Invasive cancer of the cervix after laser treatment. Br J Obstet Gynaecol 1989;96:486-8.
55. Wright TC, Gagnon MD, Richart RM, Ferenczy A. Treatment of cervical intraepithelial neoplasia using the loop electrosurgical excision procedure. Obstet Gynecol 1992;79:173-8.
56. Tidbury P, Singer A, Jenkins D. CIN 3: The role of lesion size in invasion. Br J Obstet Gynaecol 1992;99:583-6.
57. Andersen ES, Nielsen K, Pedersen B. The reliability of preconization diagnostic evaluation in patients with cervical intraepithelial neoplasia and microinvasive carcinoma. Gynecol Oncol 1995;59:143-7.
58. Duggan BD, Felix JC, Muderspach LI, Gebhart JA, Groshen S, Morrow CP, et al. Cold-knife conization versus conization by the loop electrosurgical excision procedure: A randomized, prospective study. Am J Obstet Gynecol 1999;180:276-82.
59. Naumann RW, Bell MC, Alvarez RD, Edwards RP, Partridge EE, Helm CW, et al. LLETZ is an acceptable alternative to diagnostic cold-knife conization. Gynecol Oncol 1994;55:224-8.
60. Felix JC, Muderspach LI, Duggan BD, Roman LD. The significance of positive margins in loop electrosurgical cone biopsies. Obstet Gynecol 1994;84:996-1000.
61. Zaitoun AM, McKee G, Coppen MJ, Thomas SM, Wilson PO. Completeness of excision and follow up cytology in patients treated with loop excision biopsy. J Clin Pathol 2000;53:191-6.
62. Gardeil F, Barry-Walsh C, Prendiville W, Clinch J, Turner MJ. Persistent intraepithelial neoplasia after excision for cervical intraepithelial neoplasia grade III. Obstet Gynecol 1997;89:419-22.
63. Vedel P, Jakobsen H, Kryger-Baggesen N, Rank F, Bostofte E. Five-year follow up of patients with cervical intraepithelial neoplasia in the cone margins after conization. Eur J Obstet Gynecol Reprod Biol 1993;50:71-6.
64. Kobak WH, Roman LD, Felix JC, Muderspach LI, Schlaerth JB, Morrow CP. The role of endocervical curettage at cervical conization for high-grade dysplasia. Obstet Gynecol 1995;85:197-201.
65. Moore BC, Higgins RV, Laurent SL, Marroum MC, Bellitt P. Predictive factors from cold knife conization for residual cervical intraepithelial neoplasia in subsequent hysterectomy. Am J Obstet Gynecol 1995;173:361-6.
66. Kalogirou D, Antoniou G, Karakitsos P, Botsis D, Kalogirou O, Giannikos L. Predictive factors used to justify hysterectomy after loop conization: Increasing age and severity of disease. Eur J Gynaecol Oncol 1997;18:113-6.
67. Lapaquette TK, Dinh TV, Hannigan EV, Doherty MG, Yandell RB, Buchanan VS. Management of patients with positive margins after cervical conization. Obstet Gynecol 1993;82:440-3.
68. Economos K, Perez Veridiano N, Delke I, Collado ML, Tancer ML. Abnormal cervical cytology in pregnancy: A 17-year experience. Obstet Gynecol 1993;81:915-8.
69. Yost NP, Santoso JT, McIntire DD, Iliya FA. Postpartum regression rates of antepartum cervical intraepithelial neoplasia II and III lesions. Obstet Gynecol 1999;93:359-62.
70. Connor JP. Noninvasive cervical cancer complicating pregnancy. Obstet Gynecol Clin North Am 1998;25:331-42.
71. Robinson WR, Webb S, Tirpack J, Degefu S, O'Quinn AG. Management of cervical intraepithelial neoplasia during pregnancy with LOOP excision. Gynecol Oncol 1997;64:153-5.
72. Tate DR, Anderson RJ. Recurrence of cervical dysplasia in the HIV-seropositive patient. Obstet Gynecol 2001;97:S60.
73. Holcomb K, Matthews RP, Chapman JE, Abulafia O, Lee YC, Borges A, et al. The efficacy of cervical conization in the treatment of cervical intraepithelial neoplasia in HIV-positive women. Gynecol Oncol 1999;74:428-31.
74. Wright TC Jr., Koulos J, Schnoll F, Swanbeck J, Ellerbrock TV, Chiasson MA, et al. Cervical intraepithelial neoplasia in women infected with the HIV: Outcome after loop electrosurgical excision. Gynecol Oncol 1994;55:253-8.
75. Maiman M. Management of cervical neoplasia in HIV-infected women. J Natl Cancer Inst 1998;23:43-9.
76. Maiman M, Watts DH, Andersen J, Clax P, Merino M, Kendall MA. Vaginal 5-fluorouracil for high-grade cervical dysplasia in HIV infection: A randomized trial. Obstet Gynecol 1999;94:954-61.
77. SEER Program - National Cancer Institute, USA. Available at: http://www-seer.ims.nci.nih.gov/ScientificSystems/2001. Accessed September 2002.
78. Reich O, Pickel H, Lahousen M, Tamussino K, Winter R. Cervical intraepithelial neoplasia III: Long-term outcome after cold-knife conization with clear margins. Obstet Gynecol 2001;97:428-30.
79. Soutter WP, De Barros Lopes A, Fletcher A, Monaghan JM, Duncan ID, Paraskevaidis E, et al. Invasive cervical cancer after conservative therapy for cervical intraepithelial neoplasia. Lancet 1997;349:978-80.
80. Kolstad P, Klem V. Long-term followup of 1121 cases of carcinoma in situ. Obstet Gynecol 1976;48:125-9.
81. Anderson MC. Invasive carcinoma of the cervix following local destructive treatment for cervical intraepithelial neoplasia. Br J Obstet Gynaecol 1993;100:657-63.
82. Brown JV, Peters WA, Corwin DJ. Invasive carcinoma after cone biopsy for cervical intraepithelial neoplasia. Gynecol Oncol 1991;40:25-8.
83. NCI. SEER Cancer Statistics Review: 1973-1996. Available at: http://www-seer.ims.nci.nih.gov, 2000 (vol. 2000). Accessed September 2002.
84. Ferenczy A, Choukroun D, Arseneau J. Loop electrosurgical procedure for squamous intraepithelial lesions of the cervix: Advantages and potential pitfalls. Obstet Gynecol 1996;87:332-7.
85. Chan KS, Yu KM, Lok YH, Sin SY, Tang LC. Conservative management of patients with histological incomplete excision of cervical intraepithelial after large loop excision of transformation zone. Chin Med J 1997;110:617-9.
86. Paraskevaidis E, Kitchener H, Adonakis G, Parkin D, Lolis D. Incomplete excision of CIN in conization: Further excision or conservative management? Eur J Obstet Gynecol Reprod Biol 1994;53:45-7.
87. Strand A, Wilander E, Zehbe I, Rylander E. High risk HPV persists after treatment of genital papillomavirus infection but not after treatment of cervical intraepithelial neoplasia. Acta Obstet Gynecol Scand 1997;76:140-4.
88. Jain S, Tseng CJ, Horng SG, Soong YK, Pao CC. Negative predictive value of human papillomavirus test following conization of the cervix uteri. Gynecol Oncol 2001;82:177-80.
89. Nagai Y, Maehama T, Asato T, Kanazawa K. Persistance of human papillomavirus infection after therapeutic conization for CIN 3: Is it an alarm for disease recurrence? Gynecol Oncol 2000;79:294-9.
90. Gross PA, Barrett TL, Dellinger EP, Krause PJ, Martone WJ, McGowan JE Jr., et al. Purpose of quality standards for infectious diseases. Infectious Diseases Society of America. Clin Infect Dis 1994;18:421.